Abstract: Provided are a GLP-1(7-37) polypeptide analogue, a fatty acid-modified derivative of the analogue, and a medicament comprising the derivative. Further, also provided are a preparation method of the derivative, and use of the same in the preparation of a medicament.
Abstract: Provided are an interleukin 29 (IL29) mutant protein, and a fusion protein, a conjugate, a pharmaceutical composition, a product and a kit which comprises the mutant protein. The provided IL29 mutant protein has good activity and stability, and can effectively prevent and/or treat viral infectious diseases, tumors and other diseases needing to regulate the body immune function.
Type:
Application
Filed:
February 8, 2021
Publication date:
August 24, 2023
Applicant:
SCIWIND BIOSCIENCES CO., LTD.
Inventors:
Liu YANG, Yan LI, Jing FENG, Wanjun GUO, Hai PAN
Abstract: Disclosed in the present application is a crystal polymorph of potassium N-[8-(2-hydroxybenzoyl)amino]octanoate, wherein the crystal polymorph of potassium N-[8-(2-hydroxybenzoyl)amino]octanoate is crystal Form I, and the crystal Form I has at least an X-ray powder diffraction pattern with characteristic peaks represented by 2?° of 7.83±0.2, 26.64±0.2 and 18.89±0.2. The crystal polymorph of potassium N-[8-(2-hydroxybenzoyl)amino]octanoate provided by the present application has four crystal forms, has high solubility and strong stability, can deliver drugs more effectively, increases the permeability of the delivered drugs in the gastrointestinal tract, and is beneficial to the preparation of oral preparations, such that preventive and/or therapeutic drugs can be better delivered into the body to achieve the effect of improving the bioavailability.
Type:
Application
Filed:
November 11, 2020
Publication date:
July 27, 2023
Applicant:
SCIWIND BIOSCIENCES CO., LTD.
Inventors:
Hongyang WANG, Shiyue JIANG, Yao LI, Hai PAN
Abstract: Provided are a GLP-1(7-37) polypeptide analogue, a fatty acid-modified derivative of the analogue, and a medicament comprising the derivative. Further, also provided are a preparation method of the derivative, and use of the same in the preparation of a medicament.
Abstract: A novel five-membered heteroaromatic imidazole compound and use thereof is disclosed herein. Specifically, disclosed is a compound as shown in formula (III) or a pharmaceutically acceptable salt thereof. Also disclosed is a method for treating a disease related to GLP-1 receptor such as type II diabetes.
Type:
Grant
Filed:
January 13, 2022
Date of Patent:
January 3, 2023
Assignee:
Hangzhou Sciwind Biosciences Co., Ltd
Inventors:
Tao Yu, Lu Gan, Chengde Wu, Shuhui Chen
Abstract: Provided are a GLP-1(7-37) polypeptide analogue, a fatty acid-modified derivative of the analogue, and a medicament comprising the derivative. Further, also provided are a preparation method of the derivative, and use of the same in the preparation of a medicament.