Abstract: Novel depolymerized and supersulfated heparin having a molecular weight comprised between 2000 and 9000 and a sulfation degree of at least 2.5, in which all of the primary hydroxy groups are sulfated; a process for its preparation by reacting a heparin of natural origin, or a fraction thereof with a sulfuric acid/chlorosulfonic acid mixture; and pharmaceutical compositions containing it as active ingredient, having potential antithrombotic, hypolipemic and fibrinolytic activity and useful in the prevention of thrombosis and for the treatment of atherosclerosis.

Abstract: In a method for the enzymic-colorimetric determination of urea in clinical analyses, the improvement consisting in that the sample to be tested is admixed with a composite reagent composed by urease, a buffer, an alkali-metal salicylate and a nitroprusside and, after a short incubation, a hypochlorite is added, a short additional incubation is performed and the color is measured photometrically. By this method, two reagent systems are sufficient instead of the usual three.