Abstract: Provided herein are compounds and compositions useful as modulators of ABHD12. Furthermore, the subject compounds and compositions are useful as immunotherapies in treating, for instance, cancer or infectious diseases.
Type:
Grant
Filed:
May 14, 2019
Date of Patent:
February 13, 2024
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Daisuke Ogasawara, Taka-Aki Ichu, Jonathan Hulce, Benjamin F. Cravatt
Abstract: Compounds are provided that antagonize the kappa-opioid receptor (KOR) and products containing such compounds, as well as to methods of their use and synthesis. Such compounds have the structure of Formula (I), or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope or salt thereof: wherein X, Y, R1, R2, R4, R5, R6, R7, R8 and R11 are as defined herein.
Type:
Grant
Filed:
July 30, 2021
Date of Patent:
February 13, 2024
Assignees:
BLACKTHORN THERAPEUTICS, INC., THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Edward Roberts, Miguel A. Guerrero, Mariangela Urbano, Hugh Rosen, Robert M. Jones, Candace Mae Laxamana, Xianrui Zhao, Eric Douglas Turtle
Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
Type:
Application
Filed:
October 4, 2023
Publication date:
February 8, 2024
Applicants:
Synthorx, Inc., The Scripps Research Institute
Inventors:
Jerod PTACIN, Carolina CAFFARO, Hans AERNI, Yorke ZHANG, Emil C. FISCHER, Aaron W. FELDMAN, Vivian T. DIEN, Floyd E. ROMESBERG
Abstract: There are disclosed imidazolinopyrimidinone compounds that have activity to induce TRAIL gene expression in macrophages. There is further disclosed a method for treating various cancers comprising administering effective amounts of an imidazolinopyrimidinone having the structure of Formula I herein.
Type:
Grant
Filed:
July 12, 2021
Date of Patent:
February 6, 2024
Assignee:
The Scripps Research Institute
Inventors:
Kim D. Janda, Nicholas T. Jacob, Jonathan W. Lockner
Abstract: Disclosed herein are compositions, methods, cells, engineered microorganisms, and kits for increasing the production of proteins or polypeptides comprising one or more unnatural amino acids. Further provided are compositions, cells, engineered microorganisms, and kits for increasing the retention of unnatural nucleic acids encoding the unnatural amino acids in an engineered cell, or semi-synthetic organism.
Type:
Grant
Filed:
June 12, 2020
Date of Patent:
January 23, 2024
Assignee:
The Scripps Research Institute
Inventors:
Floyd E. Romesberg, Vivian T. Dien, Aaron W. Feldman, Rebekah J. Karadeema, Lingjun Li, Michael P. Ledbetter, Anne Xiaozhou Zhou
Abstract: The present invention provides novel engineered Ebolavirus GP proteins and polypeptides, scaffolded vaccine compositions that display the engineered proteins, and polynucleotides encoding the engineered proteins and scaffolded vaccine compositions. The invention also provides methods of using such engineered Ebolavirus GP proteins and vaccine compositions in various therapeutic applications, e.g., for preventing or treating Ebolavirus infections.
Type:
Grant
Filed:
April 7, 2022
Date of Patent:
January 16, 2024
Assignee:
The Scripps Research Institute
Inventors:
Linling He, Jiang Zhu, Anshul Chaudhary, Ian Wilson
Abstract: Provided herein is a method of forming a beta-lactone from a carboxylic acid having a beta-carbon with a hydrogen atom disposed thereon. The method comprises contacting a carboxylic acid of formula (1) as described herein with an effective amount of a palladium(II) catalyst, an effective amount of an N-protected aminoacid ligand, and t-butylhydroperoxide in a solvent comprising hexafluoroisopropanol (HFIP), at about 60° C. to provide a beta-lactone of formula (2) as described herein.
Abstract: Methods and compositions are provided for extending the half-life of a therapeutic agent. A modified therapeutic agent (mTA) comprises a therapeutic agent, a staple, and a half-life extending molecule. The mTAs disclosed herein may be used to treat a disease or a condition in a subject in need thereof.
Type:
Grant
Filed:
May 11, 2021
Date of Patent:
January 9, 2024
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Weijun Shen, Pengyu Yang, Huafei Zou, Peter G. Schultz
Abstract: The invention provides a method for obtaining a broadly neutralizing antibody (bNab), including screening memory B cell cultures from a donor PBMC sample for neutralization activity against a plurality of HIV-1 species, cloning a memory B cell that exhibits broad neutralization activity; and rescuing a monoclonal antibody from that memory B cell culture. The resultant monoclonal antibodies may be characterized by their ability to selectively bind epitopes from the Env proteins in native or monomeric form, as well as to inhibit infection of HIV-1 species from a plurality of clades. Compositions containing human monoclonal anti-HIV antibodies used for prophylaxis, diagnosis and treatment of HIV infection are provided. Methods for generating such antibodies by immunization using epitopes from conserved regions within the variable loops of gp120 are provided. Immunogens for generating anti-HIV1 bNAbs are also provided. Furthermore, methods for vaccination using suitable epitopes are provided.
Type:
Grant
Filed:
July 15, 2021
Date of Patent:
December 19, 2023
Assignees:
THERACLONE SCIENCES, INC., THE SCRIPPS RESEARCH INSTITUTE, INTERNATIONAL AIDS VACCINE INITIATIVE, INC.
Inventors:
Po-Ying Chan-Hui, Katherine Doores, Michael Huber, Stephen Kaminsky, Steven Frey, Ole Olsen, Jennifer Mitcham, Matthew Moyle, Sanjay K. Phogat, Dennis R. Burton, Laura Majorie Walker, Pascal Raymond Georges Poignard, Wayne Koff, Melissa Danielle De Jean De St. Marcel Simek-Lemos
Abstract: The present invention provides redesigned soluble coronavirus S protein derived immunogens that are stabilized via specific modifications in the wildtype soluble S sequences. Also provided in the invention are nanoparticle vaccines that contain the redesigned soluble S immunogens displayed on self-assembling nanoparticles. Polynucleotide sequences encoding the redesigned immunogens and the nanoparticle vaccines are also provided in the invention. The invention further provides methods of using the vaccine compositions in various therapeutic applications, e.g., for preventing or treating coronaviral infections.
Abstract: Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.
Type:
Grant
Filed:
March 9, 2021
Date of Patent:
December 5, 2023
Assignees:
THE SCRIPPS RESEARCH INSTITUTE, SYNTHORX, INC.
Inventors:
Jerod Ptacin, Carolina Caffaro, Hans Aerni, Yorke Zhang, Emil C. Fischer, Aaron W. Feldman, Vivian T. Dien, Floyd E. Romesberg
Abstract: Disclosed herein are proteins, methods, cells, engineered microorganisms, and kits for generating a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum. Also disclosed herein proteins, methods, cells, engineered microorganisms, and kits for production of a nucleic acid molecule that comprises an unnatural nucleotide utilizing a modified nucleoside triphosphate transporter from Phaeodactylum tricornutum.
Abstract: By a genome-wide gene analysis of expression profiles of over 50,000 known or putative gene sequences in peripheral blood, the present inventors have identified a consensus set of gene expression-based molecular biomarkers associated with chronic allograft nephropathy and/or interstitial fibrosis and tubular atrophy CAN/IFTA and subtypes thereof. These genes sets are useful for diagnosis, prognosis, monitoring and/or subtyping of CAN/IFTA.
Type:
Grant
Filed:
February 27, 2020
Date of Patent:
November 21, 2023
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Daniel R. Salomon, Sunil M. Kurian, Steven R. Head
Abstract: The present disclosure provides compounds, their pharmaceutical compositions, and methods of their use for treating mesenchymally-derived or mesenchymally-transformed cancers, such as breast cancers and sarcomas, and for treating diseases or disorders that are characterized by the expression of vimentin.
Type:
Application
Filed:
July 11, 2023
Publication date:
November 2, 2023
Applicants:
The Scripps Research Institute, Board of Regents, The University of Texas System
Inventors:
Luke L. LAIRSON, Michael J. BOLLONG, Peter G. SCHULTZ, Sendurai A. Mani
Abstract: The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with the expression of the glycosyl-phosphatidylinositol (GPI)-linked GDNF family protein ?-receptor 4 (GFR?4).
Type:
Grant
Filed:
September 29, 2020
Date of Patent:
October 31, 2023
Assignees:
The Trustees of the University of Pennsylvania, The Scripps Research Institute
Inventors:
Donald L. Siegel, Vijay Bhoj, Christoph Rader, Rebecca Goydel
Abstract: Provided and described are mechanosensory polypeptides and encoding polynucleotide products and compositions thereof, methods of expressing such polypeptides and polynucleotides in a cell type of interest, and methods of inducing and/or modifying the activity and/or function of various types of cells that express the exogenous mechanosensory polypeptides using ultrasound.
Type:
Application
Filed:
May 10, 2023
Publication date:
October 26, 2023
Applicants:
Salk Institute for Biological Studies, The Scripps Research Institute
Inventors:
Sreekanth CHALASANI, Carl PROCKO, Joanne CHORY, Jose Mendoza LOPEZ, Marc Duque RAMIREZ, Corinne LEE-KUBLI, Swetha MURTHY, Ardem PATAPOUTIAN, Seyed Ali Reza MOUSAVI, William T. KEENAN, Yusuf TUFAIL, Janki PATEL
Abstract: The present disclosure relates to methods for generating broadly neutralizing bovine anti-HIV Env antibodies, compositions comprising the broadly neutralizing bovine antibodies, and methods of treatment or prevention of HIV using the broadly neutralizing bovine antibodies. In certain embodiments, a broadly neutralizing bovine antibody comprises a polyclonal F(ab) or F(ab?)2 fragment. In certain embodiments, a broadly neutralizing bovine antibody comprises a humanized bovine monoclonal antibody.
Type:
Grant
Filed:
July 12, 2018
Date of Patent:
October 24, 2023
Assignees:
International AIDS Vaccine Initiative, The Scripps Research Institute, THE TEXAS A&M UNIVERSITY SYSTEM
Inventors:
Devin Sok, Dennis R. Burton, Vaughn V. Smider, Ian Wilson, Michael Criscitiello, Waithaka Mwangi
Abstract: A high-throughput screening methods for identifying candidate anticancer medicinal agents is described herein. The candidate anticancer medicinal agents are arylfluorosulfate compounds derived from phenolic compounds. The method involves in situ generation of the arylfluorosulfate compounds in multi-well plates by reaction of phenolic compounds in DMSO with a saturated solution of SO2F2 dissolved in a solvent such as acetonitrile, in the presence of an organic base, followed by reaction of generated fluoride ion with trimethylsilanol to form volatile trimethylsilyl fluoride. Solvents, organic base, and silyl compounds are then removed, in vacuo, to afford the arylfluorosulfate compounds suitable for biological screening in cancer cell lines without further purification.
Type:
Grant
Filed:
May 11, 2020
Date of Patent:
October 10, 2023
Assignee:
THE SCRIPPS RESEARCH INSTITUTE
Inventors:
Jie Li, Zilei Liu, Suhua Li, Peng Wu, K. Barry Sharpless