Abstract: Disclosed herein are vectors that include alphavirus-based expression platforms. Also disclosed are methods associated with the alphavirus-based expression platforms and co-administration of an inhibitor of Type I interferon signaling.
Type:
Grant
Filed:
November 7, 2019
Date of Patent:
June 16, 2026
Assignee:
Seattle Project Corp.
Inventors:
Karin Jooss, Amy Rachel Rappaport, Leonid Gitlin
Abstract: Disclosed herein are compositions that include antigen-encoding nucleic acid sequences and/or antigen peptides. Also disclosed are nucleotides, cells, and methods associated with the compositions including their use as vaccines, including vectors and methods for a heterologous prime/boost vaccination strategy.
Type:
Grant
Filed:
October 3, 2022
Date of Patent:
May 5, 2026
Assignee:
Seattle Project Corp.
Inventors:
Andrew Ferguson, Raphael Rousseau, Roman Yelensky, James Xin Sun, Matthew Joseph Davis, Karin Jooss, Amy Rachel Rappaport, Ciaran Daniel Scallan, Leonid Gitlin, Christine Denise Palmer