Abstract: The disclosure relates to chemical compositions that can include anchor molecules for chemical synthesis. GAP anchor molecules can include GAP constituents, linker constituents, and spacer constituents. Anchor molecules can be used to synthetically manufacture peptides. A novel method of solution-phase peptide synthesis is also disclosed that utilizes novel group-assisted purification protecting groups to facilitate efficient, scalable chemistry to synthetically manufacture peptides.

Abstract: According to the invention, at least one tyrosine derivative, in particular N-Palmitoyl-O-methyl-L-Tyrosine, is used for a cosmetic or nutraceutical treatment and/or the manufacture of a cosmetic or nutraceutical composition for improving the general condition of the skin and/or its appendages, in particular for a pro-pigmentation effect.

Abstract: The disclosure relates to compositions that can serve as anchors for the chemical synthesis of peptides. Anchor molecules can include GAP constituents, linker constituents, amino acid constituents, and/or stopper constituents. Anchor molecules can also include anchor peptides, wherein an anchor peptide can be removably coupled with an amino acid of a given sequence and act as a GAP anchor by achieving solubility control over the target peptide as it is synthesized via the addition of one or more other amino acids: the anchor peptide can then be removed from the target peptide. A novel method of peptide synthesis that utilizes novel anchor molecules and/or anchor peptides is also presented.

Abstract: The disclosure relates to chemical compositions that can include anchor molecules for chemical synthesis. GAP anchor molecules can include GAP constituents, linker constituents, and spacer constituents. Anchor molecules can be used to synthetically manufacture peptides. A novel method of solution-phase peptide synthesis is also disclosed that utilizes novel group-assisted purification protecting groups to facilitate efficient, scalable chemistry to synthetically manufacture peptides.

Abstract: The present invention concerns a recombinant microalgae comprising a nucleic acid sequence encoding a recombinant peptide of KTTKS (SEQ ID N°1); a recombinant peptide, polypeptide or protein consisting in repeated units of SEQ ID N°1; or a derivative thereof, said nucleic acid sequence being located in the chloroplast genome of microalgae. It also relates to a method for producing a recombinant peptide of SEQ ID N°1; a recombinant peptide, polypeptide or protein consisting in repeated units of SEQ ID N°1; or a derivative thereof, wherein said method comprises the chloroplast genome transformation of a microalgae with a nucleic acid sequence encoding said recombinant protein, polypeptide or peptide. It further relates to the use of said recombinant peptide, polypeptide or protein for the cosmetic industry.

Abstract: The tetrapeptide has the general Formula X-LLAN-Z wherein at the N-terminal end X is selected from H, —CO—R1, —SO2—R1 or a biotinoyl group, at the C-terminal end Z is selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 are selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. A preferred peptide is the Pal-LLAN. This tetrapeptide can stimulate the synthesis of molecules constituting the dermal extracellular matrix, in particular collagen 1 and fibrilin 1, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, firmness/tone/elasticity/flexibility, to increase skin density and volume, for a restructuring effect and/or to fight against stretch marks, and skin sagging. The peptide is also adapted to stimulate hair growth.

Abstract: They have the general Formula X-(Xaa)nPG(Xaa)m-Z wherein Xaa is either A or V, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2—R1 or a biotinyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-AVPG-Z and X-VPGA-Z. These tetrapeptides stimulate the synthesis of molecules constituting the dermal extracellular matrix, in particular collagen 1 and 4 and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, firmness/tone/elasticity/flexibility, to increase skin density and volume, for a restructuring effect and/or to fight against stretch marks, and skin sagging.

Abstract: They have the general Formula X-(Xaa)nLE(Xaa)m-Z wherein Xaa is selected from L, K, E and D, either n=2 and m=0, or n=1 and m=1, at the N-terminal end X being selected from H, —CO—R1, —SO2-R1 or a biotinoyl group, at the C-terminal end Z being selected from OH, OR1, NH2, NHR1 or NR1R2, and R1 and R2 being selected from an alkyle, aryle, aralkyle, alkylaryl, alkoxy, saccharide and aryloxy, said group having from 1 to 24 carbon atoms. Preferred peptide sequences are X-LKLE-Z and X-ELED-Z. These tetrapeptides stimulate the synthesis of molecules constituting the ECM, in particular collagen 1 and 4, hyaluronic acid and fibronectin, and can be used for a cosmetic treatment, in particular anti-aging, anti-wrinkle and fine lines, to improve the skin mechanical properties, to increase skin density and volume, hydration, and/or to fight against stretch marks, and skin sagging.

Abstract: The present invention relates to a novel synthesis method to form particular molecules. These molecules have multiple uses, most notably in the field of protecting groups used throughout organic and synthetic chemistry. The disclosed method is safer, more cost- and time-effective, and more amenable to large scale production than those currently known in the art. The protecting groups synthesized are useful in GAP peptide synthesis.

Abstract: The treatment according to the invention provides for the use of at least one peptide of general Formula X-(Xaa)nK*TSK*X?aa-(Xaa)mZ for a non-therapeutic cosmetic treatment of keratin materials of the skin and of its integuments, including treatment of the epidermis, scalp, hair, and nails, where X, Xaa, K*, X?aa, Z, m and n are as defined. A preferred peptide is Pal-KTSKS.

Abstract: The invention provides the use of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide for the topical cosmetic treatment of the skin and of the scalp, in particular an anti-dandruff treatment. According to the invention, a CO2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.

Abstract: The composition comprises a plant extract of the Engelhardtia genus, preferably the species is Engelhardtia chrysolepsis Hance. The treatment according to the invention is a repairing treatment to improve the number of elastic fibres and the quality of its network. Skin elasticity is improved and this helps decrease jowls and eyelids drooping, and the corresponding skin folds. The treatment is particularly adapted to a pre-menopausal or menopausal woman skin.

Abstract: The present invention concerns a recombinant microalgae comprising a nucleic acid sequence encoding a recombinant peptide of KTTKS (SEQ ID No 1); a recombinant peptide, polypeptide or protein consisting in repeated units of SEQ ID No 1; or a derivative thereof, said nucleic acid sequence being located in the chloroplast genome of microalgae. It also relates to a method for producing a recombinant peptide of SEQ ID No 1; a recombinant peptide, polypeptide or protein consisting in repeated units of SEQ ID No 1; or a derivative thereof, wherein said method comprises the chloroplast genome transformation of a microalgae with a nucleic acid sequence encoding said recombinant protein, polypeptide or peptide. It further relates to the use of said recombinant peptide, polypeptide or protein for the cosmetic industry.

Abstract: The peptidic compound comprises at least an aminoacid which is lysine, ornithine, diaminopropionic acid or diaminobutyric acid or a derivative of these aminoacids, on which a carboxylic acid is grafted via a peptidic bound on the nitrogen of the lateral chain, said carboxylic acid comprising a (poly)cycle or (poly)heterocycle. Preferably, the grafted carboxylic acid is an aminoacid or a derivative, in particular selected from, a proline, a hydroxyproline or pyroglutamic acid. The peptidic compound can stimulate the synthesis of the main molecules constituting the extracellular matrix of the skin, especially collagen 1 and 4 and elastin. It can be used for topical cosmetic treatment such as a global anti-aging treatment, or for specific activities, including anti-wrinkles, moisturizing, to improve the mechanical properties of the skin, firmness/tone/elasticity/flexibility, to increase density and volume of the skin, improve skin radiance, for a restructuring effect and/or to fight stretch marks.

Abstract: A composition is described, comprising or consisting of chrysin, rosmarinic acid, at least one peptide or derivative thereof, having a sequence of 4 to 10 amino acids comprising the active sequence GQPR and a physiologically acceptable medium. A derivative corresponds to said peptide modified at the N-terminal end with an acyl (—CO—R1), sulfonyl (—SO2—R1) group or a biotinoyl group and/or at the C-terminal end with an OR1, NH2, NHR1 group or NR1R2, R1 and R2 being as defined herein and where the composition acts on the effects of light radiation on the skin and/or of its appendages, and more particularly the effects of blue light to fight against harmful effects and in a particularly advantageous manner at the same time to increase the beneficial effects by resynchronizing the circadian cycle.

Abstract: A peptide having the general Formula (1) X-(Xaa)nK*TFK*-(Xaa)m-Z??(1) is described, where the peptide helps preserve or improve the condition of the epidermis and wherein X, (Xaa)n, (Xaa)m, n, m, K* and Z are as defined.

Abstract: Provided herein are compounds of Formula A, methods for the preparation thereof, and uses thereof for treating or preventing bacterial infections.

Abstract: The treatment according to the invention provides the use of at least one peptide having the general Formula X-(Xaa)nK*TTK*X?aa-(Xaa)m-Z for a non-therapeutic cosmetic treatment of keratinous tissues of the skin and of its appendages, where X, Xaa, n, K*, X?aa, m and Z are as defined. A preferred peptide is the Pal-KTTKS.

Abstract: The invention provides the use of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide for the topical cosmetic treatment of the skin and of the scalp, in particular an anti-dandruff treatment. According to the invention, a CO2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.

Abstract: The invention provides a method for the topical non therapeutical cosmetic treatment of the scalp comprising applying to the scalp an effective amount of at least one alkyl-phthalide or a plant extract comprising mainly said alkyl-phthalide. In particular, the treatment is an anti-dandruff treatment. According to the invention, a CO2 supercritical extract of Apium graveolens seeds consisting mainly of sedanenolide may be used.