Abstract: Induction of an antigen-specific T-lymphocyte response in a T-lymphocyte culture, e.g. a primary cytotoxic T-lymphocyte (CTL) response, by loading antigen-presenting vehicles which carry empty MHC molecules with an antigen-derived T-cell-immunogenic MHC-binding peptide, culturing T-lymphocytes in the presence of the peptide-loaded antigen-presenting vehicles under specific T-lymphocyte response-inducing conditions. Optionally, an antigen-specific T-lymphocyte is isolated from the resulting culture and cultured. The process can be used for preparing CTL which are specific for viral or other foreign antigens, or CTL which are specific for autologous peptides. The process can also be used for the identification of peptides that are capable of binding to MHC and inducing a T cell response.

Abstract: The present invention relates to cultured cells of Quillaja sp. For the preparation of active substances from Quillaja sp., such as saponins. The cells may either originate from a callus tissue culture or from a suspension cell culture. Preferred Quillaja sp. are species selected from the group consisting of Quillaja saponaria Molina, Quillaja smegmadermos, Quillaja brasiliesis. The invention further relates to active substances extracted from cultured cells of Quillaja sp. and to preparations comprising these active substances, or a non-dialysable or a dialysable fraction thereof, to methods for preparing the active substances and to various agents, comprising the dialyzable and/or the non-dialysable fraction of an extract of cultured cells of Quillaja sp. And having various properties.

Abstract: A peptide comprising an amino acid sequence derived from human p53 protein, wherein said amino acid sequence has the ability to bind to a human MHC Class I molecule. Its use in prophylactic or therapeutic treatment of diseases such as human cancers showing p53 protein overexpression, and its use in induction of primary p53-specific T cells that can be used in therapeutic treatment. Its use in diagnostic tests or assays.

Abstract: The invention relates to a hollow electrode for an electrochemical cell which is provided with at least one inlet and one outlet opening for gases, which electrode is made from an inorganic material and is provided on the outside with a gastight layer, which inorganic material is a mixed conductor. The electrochemical cell is preferably of plate-type construction, top and bottom sections being flat. The invention further encompasses an electrochemical cell containing at least an electrode according to the invention.