Patents Assigned to Seedlings Life Science Ventures, LLC.
  • Patent number: 11471628
    Abstract: A system and accompanying assembly, of integrated or modular construction, for inflating and monitoring pressure within a retaining cuff including a housing having a pressure chamber connected in fluid communication with a fluid pressure source and a fluid communicating connection with the retaining cuff. Associated control circuitry includes a pressure sensor disposable in fluid communication with the pressure chamber and the retaining cuff, via the fluid communicating connection and structured to concurrently determine and monitor pressure within the pressure chamber and the retaining cuff. The control circuitry is cooperatively structured with the pressure sensor and other operative components to establish dynamic multilevel sampling capabilities, calibration parameters stored within the control circuitry prior to use and limited or single use capabilities of the assembly.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: October 18, 2022
    Assignee: Seedlings Life Science Ventures, LLC
    Inventors: Stephen Jay Lowenstein, Keith Rubin, Ken Solovay, Timothy Vandermey, Klaus Lessnau, Michael R. Cole
  • Patent number: 10493226
    Abstract: A system and accompanying assembly, of integrated or modular construction, for inflating and monitoring pressure within a retaining cuff including a housing having a pressure chamber connected in fluid communication with a fluid pressure source and a fluid communicating connection with the retaining cuff. Associated control circuitry includes a pressure sensor disposable in fluid communication with the pressure chamber and the retaining cuff, via the fluid communicating connection and structured to concurrently determine and monitor pressure within the pressure chamber and the retaining cuff. The control circuitry is cooperatively structured with the pressure sensor and other operative components to establish dynamic multilevel sampling capabilities, calibration parameters stored within the control circuitry prior to use and limited or single use capabilities of the assembly.
    Type: Grant
    Filed: October 30, 2013
    Date of Patent: December 3, 2019
    Assignee: Seedlings Life Science Ventures, LLC
    Inventors: Stephen Jay Lowenstein, Keith Rubin, Ken Solovay, Timothy Vandermey, Klaus Lessnau, Michael R. Cole
  • Patent number: 8550078
    Abstract: An assembly structured to inflate a retaining or pressure cuff associated with an artificial airway tube such as an endotracheal and/or tracheotomy tube and concurrently monitor pressure therein including a casing having an interior pressure chamber. A pump assembly is movably connected to the casing and structured to force fluid flow to the retaining cuff through said pressure chamber. An indicator member is disposed within the casing, is visually accessible through casing window, and is variably positionable dependent on and indicative of existing pressure within the retaining cuff. The existing pressure within the pressure chamber is substantially equivalent to that within the retaining cuff thereby facilitating the variable position of the indicator member to indicate pressure within the cuff. A junction is disposed between the casing and an inflation lumen to the restraining cuff and is structured to allow disconnection between the casing and the lumen but prevent reconnection thereto.
    Type: Grant
    Filed: March 10, 2010
    Date of Patent: October 8, 2013
    Assignee: Seedlings Life Science Ventures, LLC.
    Inventors: Stephen Jay Lowenstein, Michael R. Cole, Klaus D. Lessnau, Keith Rubin, James M. Sellers
  • Patent number: 8403583
    Abstract: An assembly structured to clean the head portion of a stethoscope comprising a housing including a path of travel along which the head portion passes during cleaning. A supply of cleaning fluid associated with a dispenser assembly is cooperatively disposed relative to an activating assembly. The activating assembly is operated in moveable engagement with the head portion, and activates the dispenser assembly when engaged by the head portion as it passes along the path of travel. The dispenser assembly delivers the cleaning fluid to an applicator assembly which distributes the cleaning fluid to the head portion and facilitates the cleaning thereof and removal of excess cleaning fluid there from. At least one disinfectant agent is dispersed within or comprises a portion of the housing and is formulated to be destructively effective against pathogenic bacteria, such as in the spore form, which is generally not affected by the cleaning fluid.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: March 26, 2013
    Assignee: Seedlings Life Science Ventures, LLC.
    Inventors: Michael Perlman, James M. Sellers, Keith Rubin, Mathew Cardinali, Michael R. Cole, Sidney Perlman
  • Patent number: 8393818
    Abstract: An assembly structured to restrict contamination of individuals from association with the heads of stethoscope comprising a housing including a path of travel along which the head portion passes. Different embodiments include the dispensing of cleaning fluid or the delivery of protective barriers onto predetermined portions of the stethoscope heads, while passing along the path of travel. A dispenser assembly and a cooperatively disposed activating assembly are manually operated by moveable, driving engagement with the head portion passing through the housing. The activating assembly is thereby operatively positioned to activate the dispenser assembly when engaged by a head passing along the path of travel. Differently structured dispenser assemblies function to either deliver the cleaning fluid or individually dispense the barriers onto different heads, so as to either facilitate the cleaning or protective covering of exposed surfaces of the stethoscope heads, dependent on the embodiment utilized.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: March 12, 2013
    Assignee: Seedlings Life Science Ventures, LLC.
    Inventors: Michael Perlman, James M. Sellers, Keith Rubin, Mathew Cardinali, Michael R. Cole, Sidney Perlman
  • Publication number: 20110300075
    Abstract: Progressive multifocal leukoencephalopathy (PML) has been identified in patients taking natalizumab (NMAB) for the treatment of multiple sclerosis (MS). This patent application provides a novel method of patient screening and monitoring intended to decrease the risk of PML and other opportunistic central nervous system (CNS) diseases in patients undergoing MS therapy with NMAB, and proposes a novel method of screening and monitoring intended to decrease the risk of opportunistic disease processes of the CNS during the treatment of other medical disorders with NMAB.
    Type: Application
    Filed: June 24, 2011
    Publication date: December 8, 2011
    Applicant: Seedlings Life Science Ventures, LLC
    Inventors: Keith H. Rubin, Steven Glazer
  • Patent number: 7972775
    Abstract: Progressive multifocal leukoencephalopathy (PML) has been identified in patients taking natalizumab (NMAB) for the treatment of multiple sclerosis (MS). This patent application provides a novel method of patient screening and monitoring intended to decrease the risk of PML and other opportunistic central nervous system (CNS) diseases in patients undergoing MS therapy with NMAB, and proposes a novel method of screening and monitoring intended to decrease the risk of opportunistic disease processes of the CNS during the treatment of other medical disorders with NMAB.
    Type: Grant
    Filed: February 24, 2006
    Date of Patent: July 5, 2011
    Assignee: Seedlings Life Science Ventures, LLC
    Inventors: Keith H. Rubin, Steven Glazer
  • Patent number: 7942597
    Abstract: An assembly structured to restrict contamination of individuals from association with the heads of stethoscope comprising a housing including a path of travel along which the head portion passes. Different embodiments include the dispensing of cleaning fluid or the delivery of protective barriers onto predetermined portions of the stethoscope heads, while passing along the path of travel. A dispenser assembly and a cooperatively disposed activating assembly are manually operated by moveable, driving engagement with the head portion passing through the housing. The activating assembly is thereby operatively positioned to activate the dispenser assembly when engaged by a head passing along the path of travel. Differently structured dispenser assemblies function to either deliver the cleaning fluid or individually dispense the barriers onto different heads, so as to either facilitate the cleaning or protective covering of exposed surfaces of the stethoscope heads, dependent on the embodiment utilized.
    Type: Grant
    Filed: August 28, 2009
    Date of Patent: May 17, 2011
    Assignee: Seedlings Life Science Ventures, LLC
    Inventors: Michael Perlman, James M. Sellers, Keith Rubin, Mathew Cardinali, Michael R. Cole, Sidney Perlman
  • Patent number: 7503335
    Abstract: An assembly structured to clean the head portion of a stethoscope comprising a housing including a path of travel along which the head portion passes during cleaning. A supply of cleaning fluid is associated with a dispensing assembly which is cooperatively disposed relative to an activating assembly. The activating assembly is manually operated due to moveable engagement with the head portion as it travels along the path of travel. The activating assembly is thereby operatively positioned to activate the dispenser assembly when engaged by the head portion as it passes along the path of travel. The dispensing assembly delivers the cleaning fluid to an applicator assembly which distributes the cleaning fluid to the head portion and facilitates the cleaning thereof and removal of excess cleaning fluid there from.
    Type: Grant
    Filed: March 24, 2008
    Date of Patent: March 17, 2009
    Assignee: Seedlings Life Science Ventures, LLC.
    Inventors: Michael Perlman, James M. Sellers, Keith Rubin, Mathew Cardinali, Michael R. Cole, Sidney Perlman
  • Patent number: 7406973
    Abstract: An assembly structured to clean the head portion of a stethoscope comprising a housing including a path of travel along which the head portion passes during cleaning. A supply of cleaning fluid is associated with a dispensing assembly which is cooperatively disposed relative to an activating assembly. The activating assembly is manually operated due to moveable engagement with the head portion as it travels along the path of travel. The activating assembly is thereby operatively positioned to activate the dispenser assembly when engaged by the head portion as it passes along the path of travel. The dispensing assembly delivers the cleaning fluid to an applicator assembly which distributes the cleaning fluid to the head portion and facilitates the cleaning thereof and removal of excess cleaning fluid there from.
    Type: Grant
    Filed: March 23, 2007
    Date of Patent: August 5, 2008
    Assignee: Seedlings Life Science Ventures, LLC
    Inventors: Michael Perlman, James M. Sellers, Keith Rubin, Mathew Cardinali, Michael R. Cole, Sidney Perlman
  • Patent number: 6979316
    Abstract: An auto-injector for rapid delivery of a bolus of injectable medication has a generally flat, sealed housing with small peripheral dimensions, approximating those of a credit card. A syringe, configured to be contained within the flat housing is pre-filled with the medication. The housing contains a mechanism that, when triggered, automatically drives the syringe and needle forwardly to an injection position and then continues to compress the volume of the syringe to effect rapid injection. The forward injection end of the device includes an actuator that also conceals and protects the needle at all times and, prevents post-injection hazards. The flat faces of the device have graphic symbols and other visual indicia relating to the operation and condition of the device. The device enables a simple three-step operation that reduces the risk of improper use.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: December 27, 2005
    Assignee: Seedlings Life Science Ventures LLC
    Inventors: Keith H. Rubin, James M. Sellers, Haydn B. Taylor
  • Patent number: 6863654
    Abstract: A method of identifying a patient's urethral anatomic course for the precise placement of a treatment element into the patient's prostate, wherein a catheter containing an imaging bladder is introduced into a urethra until it is generally aligned with a treatment site of the prostate. An imaging probe is positioned relative to the treatment site and the urethra and is activated to obtain a real time image of the treatment site. The bladder is filled to define an acoustic interface between its interior and the urethral wall. A boundary of the urethra is identified at the acoustic interface during placement of the treatment element to position it relative to the urethra. A urethral identification system includes a catheter having the bladder spaced from the tip thereof and inflated allowing the bladder to contact the urethral wall and define the acoustic interface that is visible utilizing an ultrasound imaging device.
    Type: Grant
    Filed: May 15, 2003
    Date of Patent: March 8, 2005
    Assignee: Seedlings Life Science Ventures, LLC.
    Inventors: Stephen M. Zappala, Jim Sellers, Keith Rubin
  • Patent number: D652142
    Type: Grant
    Filed: August 5, 2008
    Date of Patent: January 10, 2012
    Assignee: Seedlings Life Science Ventures, LLC
    Inventors: Michael R. Cole, Mathew Cardinali, James M. Sellers, Michael Perlman, Keith Rubin
  • Patent number: D685469
    Type: Grant
    Filed: January 10, 2012
    Date of Patent: July 2, 2013
    Assignee: Seedlings Life Science Ventures, LLC.
    Inventors: Michael R. Cole, Mathew Cardinali, James M. Sellers, Michael Perlman, Keith Rubin