Abstract: An apparatus for feeding a product box includes a stacking unit where product boxes are stacked, a release unit where the product boxes are released, a rotation guide structure, and a conveyer where a rotated product box is provided. The release unit is disposed under the stacking unit. The rotation guide structure is disposed under the release unit. In a first mode, the rotation guide structure supports a product box placed in a first position of the release unit among the product boxes. In a second mode, the rotation guide structure guides the product box so that the product box is rotated while the product box placed in the first position of the release unit is dropped. The conveyer is disposed under the rotation guide structure.

Abstract: The present invention relates to a seal inspection device for inspecting seals of a container. Specifically, according to an embodiment of the present invention, provided is the seal inspection device for inspecting the sealing of a container, comprising: an irradiation unit for irradiating light along an optical path extending in a first direction; a sensor unit for detecting the light traveling along the optical path; and a pressing module for pressing the sealing of the container, wherein the pressing module includes a plurality of pressing units arranged on the optical path, and the pressing unit can be selectively located at a first position for blocking the light from reaching the sensor unit and a second position for allowing the light to reach the sensor unit.

Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: A method for analyzing the activity of a nucleic acid polymerase of interest using a self-dimer primer is disclosed. The method requires fewer factors to be considered in design and thus are easy to design, compared to conventional methods using both primers and templates. In addition, the method is simple, fast, cost-effective, safe, and user-friendly compared to conventional methods using radioisotopes.

Abstract: According to an embodiment, a mobile diagnostic structure comprises a housing including a space therein; a partitioning module partitioning the space to include a preparation room and an analysis room; an inlet module providing an incoming path from an outside to the preparation room for a raw sample; and a transfer module providing a transfer path from the preparation room to the analysis room, for a pre-treated sample which is a result of pre-treating the raw sample in the preparation room.

Abstract: The automated production system include a first feeding device feeding a plurality of grouped bodies or a plurality of grouped tubes, a dispensing device including dispensing units that dispense a solution to each of the bodies included in one grouped bodies, in a single dispensing process step, a first vision inspection device inspecting whether a dispensing defect of the solution contained in each of the bodies included in one grouped bodies occurs, in a single dispensing defect inspection process step, a first defect product box including dispensing defect spaces where the number of the dispensing defect spaces is the same as the number of the dispensing units, a transferring device transferring each of the tubes included in one grouped tubes by gripping each of the tubes, and a controller configured to control the transferring device so that a dispensing defect tube is released to a predetermined dispensing defect space.

Abstract: Provided a thermal cycler. In a case in which plurality of heat sinks participate in thermal control of a plurality of thermally independent sample holders for reliable nucleic acid reactions of the plurality of sample holder, a barrier is present between the adjacent heat sinks.

Abstract: The present disclosure relates to detection of target nucleic acid by LPHO-assisted PTO cleavage and extension (L-PTOCE) assay. The method and composition according to the present disclosure ensures detection of one or more target nucleic acids with improved accuracy and convenience.

Abstract: Novel uracil-DNA glycosylase (UDG) derived from Photobacterium leiognathi and uses thereof are disclosed. The novel UDG is an enzyme isolated from Photobacterium leiognathi, which is a psychrophilic bacterium, and is characterized by having an activity of degrading uracil bases from uracil-containing DNA substrate and being easily denatured at low temperatures. Accordingly, the UDG can be effectively used to eliminate carryover contamination occurring during the nucleic acid amplification reaction, resulting in increased accuracy (elimination of false positives), purity and amplification efficiency in nucleic acid amplification reactions.

Abstract: A method, particularly a loop-mediated isothermal amplification (LAMP) method for amplifying a target nucleic acid using beta-hydroxy acid is disclosed. The beta-hydroxy acid used in the method can improve the amplification rate of a target nucleic acid to reduce the time required for a LAMP reaction as well as inhibit non-specific amplification to reduce the possibility of false positives.

Abstract: A tagged loop primer and an isothermal nucleic acid amplification method using the tagged loop primer are disclosed. The tagged loop primer contains a single-stranded interactive dual labeling system. The tagged loop primer for a loop-mediated isothermal amplification reaction can be easily prepared, and furthermore, Using the tagged loop enables the effective simultaneous detection of both single target nucleic acids and multiple target nucleic acids.

Abstract: The present invention relates to a method for evaluating the performance of a hot start nucleic acid polymerase, a method for obtaining a quality control-capable (QC-able) hot start nucleic acid polymerase, and a method for providing a blended hot start nucleic acid polymerase that mimics the performance of a target hot-start nucleic acid polymerase. According to the present invention, by using an activity profile of a hot start nucleic acid polymerase for heat activation time, it is possible to evaluate the performance of the hot start nucleic acid polymerase, to provide a QC-able hot start nucleic acid polymerase, and to provide a blended nucleic acid polymerase that mimics the performance of a target hot start nucleic acid polymerase.

Abstract: A method for detecting a target nucleic acid in a sample by Quenching-PTO Cleavage and Extension (Q-PTOCE) assay is disclosed. The method has an advantage in that the signal detection temperature can be selected within a higher temperature range by utilizing not only the cleavage of the Q-PTO and hybridization between the reporter-carrying fragment and the CTO, but also the extension of the reporter-carrying fragment after hybridization.

Abstract: Provided is a tube conveying device for conveying tubes located at preset positions among a plurality of tubes in a storage part in which the plurality of tubes are arranged. The tube conveying device may comprise: a body; a suction structure including suction members that are located on the bottom surface of the body and suction air so as to maintain contact with the upper surface of the tube; and an elastic structure including pusher blocks that protrude from the bottom surface of the body and provide an elastic force against the upper surface of the tube in the direction from the body to the tube, wherein at least one of the pusher blocks is arranged on the bottom surface of the body so as to be located between the suction members.

Abstract: According to the disclosure, a target analyte detection cartridge includes a sample chamber into which sample is inserted, a metering chamber connected to the sample chamber to meter a predetermined amount of sample, a mixing chamber connected to the metering chamber to receive a magnet bead, and a waste chamber connected to the metering chamber. The metering chamber has one side connected to each of the sample chamber and the mixing chamber and another side connected to the waste chamber. A first pneumatic flow path to which pneumatic pressure is provided is connected to a waste flow path that joins the other side of the metering chamber to connect the metering chamber and the waster chamber.

Abstract: An amplification data display method according to the present invention comprises the steps of: displaying a plate display area and an integrated data display area; displaying, in the plate display area, plates where nucleic acid amplification reactions have been performed; and displaying amplification data in the integrated data display area, wherein: two or more plates are displayed in the plate display area; each of the plates includes a plurality of reaction wells; the amplification data are generated from the reaction wells by the nucleic acid amplification reactions; and amplification data for a plurality of reaction wells selected from the reaction wells of two or more of the displayed plates are displayed in the integrated data display area.

Abstract: The present invention relates to a computer-implemented method for providing alignment information of oligonucleotides for a target nucleic acid sequence. The present invention can provide semi-global alignment of oligonucleotides for a target nucleic acid sequence by applying dynamic programming. The present invention can provide alignment information on the entire length of an oligonucleotide more accurately and at a faster rate with less computer resources than conventional methods, and can provide the coverage of an oligonucleotide for a plurality of target nucleic acid sequences.

Abstract: The present invention relates to a method for amplifying at least three target nucleic acid molecules with reduced primer dimer formation in a multiplex amplification reaction. The method of present invention can inhibit primer dimer formation and hence generation of nonspecific amplification products in an effective manner in a multiplex amplification reaction for at least three target nucleic acid molecules.

Abstract: A light detection module according to the present disclosure includes an optical fiber mounting unit having a plurality of optical fibers disposed on one side thereof; a filter wheel spaced apart from the other side of the optical fiber mounting unit, the filter wheel having a plurality of filters; a drive unit for rotating the filter wheel; a light source unit for generating excitation light passing through the filter wheel; and a detection unit for detecting emission light passing through the filter wheel, wherein the plurality of filters includes a plurality of excitation light filters for filtering the excitation light and a plurality of emission light filters for filtering the emission light.

Abstract: The present invention relates to the detection of a target nucleic acid sequence by a PTOCE (PTO Cleavage and Extension) assay. The present invention detects a target nucleic acid sequence in which the PTO (Probing and Tagging Oligonucleotide) hybridized with the target nucleic acid sequence is cleaved to release a fragment and the fragment is hybridized with the CTO (Capturing and Templating Oligonucleotide) to form an extended duplex, followed by detecting the presence of the extended duplex. The extended duplex provides signals (generation, increase, extinguishment or decrease of signals) from labels indicating the presence of the extended duplex and has adjustable Tm value, which are well adoptable for detection of the presence of the target nucleic acid sequence.