Patents Assigned to Seibutsu Kagaku Kenkyujo
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Publication number: 20090088390Abstract: The present invention provides a polypeptide inducing the production of an antibody in permucosal administration in the presence of no immunological adjuvant, a composition containing the polypeptide, and use thereof. The present invention solves the above object by providing a polypeptide inserted with a cell attachment motif of a cell adhesive molecule to the peptide which has an amino acid sequence of multiagretope type T cell epitope at the amino terminal side of an inserted linker peptide, and an amino acid sequence of a B cell epitope at the carboxyl terminal side of the inserted linker peptide, a composition containing the polypeptide, and use thereof.Type: ApplicationFiled: June 9, 2008Publication date: April 2, 2009Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventor: Toshiki NISHIZAWA
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Publication number: 20090076278Abstract: The present invention provides novel organic compounds, which absorb the light in the ultra violet and the infrared regions, have improved light tolerance and solubility in solvents, and have thermal tolerance suitable for uses to which the organic compounds are applied, and provides uses of the same. The above objects are solved by providing indolenine compounds and methine dyes, which have a bis-indolenine skeleton composed of two indolenine rings linked together at their respective C-3 positions via a divalent linking group, and by providing optical recording media containing the methine dyes.Type: ApplicationFiled: November 7, 2006Publication date: March 19, 2009Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Yasufumi Dan-Oh, Masahiko Toki, Kentaro Yano, Yasushi Aizawa
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Publication number: 20080241904Abstract: A novel process for producing isomaltose and uses thereof and comprising the steps of contacting saccharides, which have a glucose polymerization degree of at least two and ?-1,4 glucosidic linkage as a linkage at the non-reducing end, with an ?-isomaltosylglucosaccharide-forming enzyme, in the presence or the absence of ?-isomaltosyl-transferring enzyme to form a-isomaltosylglucosaccharides, which have a glucose polymerization degree of at least three, ?-1,6 glucosidic linkage as a linkage at the non-reducing end, and ?-1,4 glucosidic linkage as a linkage other than the non-reducing end, and/or to form cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-(1?}; contacting the saccharides so formed with isomaltose-releasing enzyme to release isomaltose; and collecting the released isomaltose; and uses thereof.Type: ApplicationFiled: July 12, 2007Publication date: October 2, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Michio Kubota, Tomoyuki Nishimoto, Takanobu Higashiyama, Hikaru Watanabe, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20080221045Abstract: An object of the present invention is to provide a means for improving hepatic function of mammals including humans to normal condition. The present invention achieves the above object by providing a hepatic function-improving agent comprising ?-glucosyl-hesperidin as an effective ingredient.Type: ApplicationFiled: November 21, 2005Publication date: September 11, 2008Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Hitoshi Mitsuzumi, Mika Takami, Yoshikatsu Miwa, Hiroto Chaen, Toshio Miyake
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Publication number: 20080214499Abstract: The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.Type: ApplicationFiled: February 19, 2008Publication date: September 4, 2008Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazuyuki Oku, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Patent number: 7419727Abstract: This invention has an objective to improve durability at elevated temperature in organic electroluminescent devices using coumarin derivatives as dopant in a luminescent layer. This invention attains the above objective by providing in the organic electroluminescent devices formed by laminating an anode, a hole injection layer, a hole transportation layer, a luminescent layer, an electron transportation layer and a cathode in this order, the luminescent layer which comprises as dopant the green light-emitting coumarin derivative and hole- and electron-transporting substances as host; said coumarin derivative consisting of a plurality of coumarin groups bound to an aromatic ring, heterocycle, or any combination thereof, and exhibiting a glass transition point of 150° C. or higher or a melting point of 297° C. or higher.Type: GrantFiled: February 12, 2004Date of Patent: September 2, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazushige Kojima, Kojiro Tachi, Hisayoshi Fujikawa, Koji Noda, Masahiko Ishii, Yasunori Taga, Makoto Satsuki, Makoto Fujiwara, Natsuko Ishida, Sadaharu Suga
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Patent number: 7414038Abstract: The object of the present invention is to provide an embolizing material which is easily handleable and stable in quality and is solved by providing an embolizing material comprising an ester derivative of a polysaccharide having a weight-average molecular weight of 10,000-500,000 daltons and an average substitution degree of acyl group of over two; an embolizing agent for arteriovenous aneurysm, which comprises the embolizing material and an appropriate physiologically acceptable water-soluble organic acid; and a method of producing an embolizing agent, which comprises a step of dissolving the embolizing material in an appropriate physiologically acceptable water-soluble organic solvent.Type: GrantFiled: October 5, 2001Date of Patent: August 19, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazushi Kinugasa, Shinya Mandai
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Patent number: 7405048Abstract: A monoclonal antibody which is specific to a polypeptide having a molecular weight of 18,500±3,000 daltons on SDS-PAGE and a pI of 4.9±1.0 on chromatofocusing. The monoclonal antibody is obtainable from hybridomas and can be used for the purification and detection of the polypeptide. The polypeptide strongly induces the IFN-? production by immunocompetent cells with only a small amount, and dose not cause serious side effects even when administered to human in a relatively-high dose.Type: GrantFiled: December 24, 2002Date of Patent: July 29, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Toshio Kunikata, Mutsuko Taniguchi, Keizo Kohno, Masashi Kurimoto
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Patent number: 7402375Abstract: The present invention provides organic dye compounds having their absorption maxima in a region ranging from the ultraviolet region to a relatively short wavelength visible region and uses thereof. The present invention provides specific monomethine cyanine dyes, light absorbents and optical recording media comprising the monomethine cyanine dyes, and a process for producing the monomethine cyanine dyes which comprises a step of reacting a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having a reactive methyl group with a quaternary ammonium salt of nitrogen atom-containing heterocyclic compound having an appropriate leaving group.Type: GrantFiled: May 16, 2003Date of Patent: July 22, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Chiaki Kasada, Yasushi Aizawa, Toshio Kawata, Shigeo Yasui
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Patent number: 7384636Abstract: The present invention provides a polypeptide inducing the production of an antibody in permucosal administration in the presence of no immunological adjuvant, a composition containing the polypeptide, and use thereof. The present invention solves the above object by providing a polypeptide inserted with a cell attachment motif of a cell adhesive molecule to the peptide which has an amino acid sequence of multiagretope type T cell epitope at the amino terminal side of an inserted linker peptide, and an amino acid sequence of a B cell epitope at the carboxyl terminal side of the inserted linker peptide, a composition containing the polypeptide, and use thereof.Type: GrantFiled: March 29, 2004Date of Patent: June 10, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventor: Toshiki Nishizawa
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Patent number: 7375225Abstract: 4-Cyanocoumarin derivatives which have a distinct sensitivity to visible light, distinct luminescent ability, and satisfactory applicability for photochemical polymerization, dye lasers, and organic electroluminescent elements. Since most of the derivatives have a fluorescent maximum wavelength of 600 to 650 nm, particularly, 610 to 630 nm, they are extremely useful as luminescent agents for organic EL elements which emit visible light in a red-color region, and can be quite useful as luminescent agents in organic EL elements and laser-active substances in dye lasers, as well as luminous bodies as lighting sources for lighting devices, and information displays for visually displaying information.Type: GrantFiled: January 21, 2003Date of Patent: May 20, 2008Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Yoshio Taniguchi, Toshiki Koyama, Chihaya Adachi, Tomoyasu Saitou, Makoto Satsuki, Akira Shinpo, Sadaharu Suga, Shizuo Tokito, Hisayoshi Fujikawa, Koji Noda, Atsushi Miura, Yasunori Taga
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Publication number: 20080113938Abstract: The present invention has an object to provide an accelerator for mineral absorption and a composition containing the accelerator. The object is solved by providing an accelerator for mineral absorption comprising cyclic tetrasaccharide and/or saccharide derivatives thereof and a composition containing the accelerator.Type: ApplicationFiled: December 20, 2007Publication date: May 15, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Kazuyuki OKU, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Patent number: 7355014Abstract: A human IFN-? inducing polypeptide and its nucleotide sequence was isolated, purified and characterized. Pharmaceutical compositions containing this novel INF-? inducing polypeptide or active fragments thereof are formulated and monoclonal antibodies are raised against this polypeptide or antigenic fragments thereof. The polypeptide can be used in a method for treating diseases susceptive to treatment with INF-?, and methods for enhancing the cytotoxicity of NK cells or for inducing the formation of LAK cells, such as to treat tumors and malignant pathologies.Type: GrantFiled: October 16, 2006Date of Patent: April 8, 2008Assignee: Kabushiki Kaisha Hay Ashibara Seibutsu Kagaku KenkyujoInventors: Shimpei Ushio, Kakuji Torigoe, Todao Tanimoto, Haruki Okamura, Masashi Kurimoto, Shigeharu Fukuda, Toshio Kunikata, Mutsuko Taniguchi, Keizo Kohno
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Publication number: 20080032350Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-?-D-glucopyranosyl-(163)-?-D-glucopyranosyl-Type: ApplicationFiled: May 9, 2007Publication date: February 7, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20080000034Abstract: An objective of this invention is to extend the range of choosing organic dye compounds as radiation-absorbing agents in a variety of fields by providing a novel organic dye compound which absorbs short-wavelength visible radiation and exhibits a superior in optical resistance, solubility in solvents, and heat characteristics required in a novel field in which the organic dye compound is applied: The objective is attainable by providing a cyanine dye which has a specific structure and exhibits a major adsorption maximum at a wavelength longer than 400 nm in a solution.Type: ApplicationFiled: February 24, 2005Publication date: January 3, 2008Applicant: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Yasushi Aizawa, Yoshinori Koyama, Ayashi Noguchi
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Publication number: 20080003651Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{66)-?-D-glucopyranosyl-(163)-?-D-glucopyranosyl-Type: ApplicationFiled: May 9, 2007Publication date: January 3, 2008Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
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Patent number: 7309697Abstract: An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{?6)-?-D-glucopyranosyl-(1?4)-?-D-glucopyranosyl-(1?6)-?-D-glucopyranosyl-(1?4)-?-D-glucopyranosyl-(1?6}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.Type: GrantFiled: August 26, 2004Date of Patent: December 18, 2007Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Kazuhisa Mukai, Hikaru Watanabe, Tomoyuki Nishimoto, Michio Kubota, Shigeharu Fukuda, Toshio Miyake
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Patent number: 7252892Abstract: An organic electroluminescent (EL) device which contains a novel coumarin derivative composed of a coumarin ring, a naphthalene ring with one or more hydrocarbon groups, and a five-membered hetero ring condensed with the naphthalene ring so as to give an electronic resonance through the coumarin and naphthalene rings. The coumarin derivative emits a visible luminescence with a satisfactory color purity, which consistently continues over a long period of time even at an elevated temperature when used in such an organic device.Type: GrantFiled: April 23, 2002Date of Patent: August 7, 2007Assignees: Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo, Kabushiki Kaisha Toyota JidoshokkiInventors: Makoto Satsuki, Natsuko Ishida, Sadaharu Suga, Hisayoshi Fujikawa, Yasunori Taga
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Patent number: 7241606Abstract: The object of the present invention is to provide an ?-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an ?-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the ?-1,6 glucosidic linkage as a linkage at the non-reducing end and the ?-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the ?-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the ?-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; ?-isomaltosyl-transferring method using the enzyme; method for forming ?-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{?6)-?-D-glucopyranosyl-(1?3)-?-D-glucopyranosyl-Type: GrantFiled: July 25, 2001Date of Patent: July 10, 2007Assignee: Kabushiki Kaisha Hayashibara Seibutsu Kagaku KenkyujoInventors: Michio Kubota, Keiji Tsusaki, Takanobu Higashiyama, Shigeharu Fukuda, Toshio Miyake
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Publication number: 20070140984Abstract: The present invention has objects to provide a functional powdery product prepared by allowing carriers to support one or more members selected from vitamin glycosides, and to provide external dermatological agents having satisfactory usability, which contain the above functional powdery products and effectively exert the functions of vitamins. These objects are solved by providing a functional powdery product prepared by allowing carriers such as saccharides to support one or more members selected from vitamin glycosides, and by providing external dermatological agents incorporated with the functional powdery products.Type: ApplicationFiled: March 14, 2005Publication date: June 21, 2007Applicant: KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJOInventors: Hajime Kusano, Masato Takatori, Norio Oga