Patents Assigned to Seismic Pharmaceuticals
  • Androstane derivatives with activity as pure or predominantly pure stimulators of SERCA2a for the treatment of heart failure
    Patent number: 12503484
    Abstract: Compounds and compositions for the activation of SERCA2a are disclosed. In particular, provided are compounds that act as predominantly pure or pure SERCA2a activators while only moderately inhibiting the Na+/K+ ATPase. In general, the disclosed compounds are derivatives of androstane having the formula (I). Also disclosed herein are pharmaceutical compositions comprising one or more of the compounds of formula (I) for use for the treatment of heart failure.
    Type: Grant
    Filed: October 8, 2020
    Date of Patent: December 23, 2025
    Assignee: Seismic Pharmaceuticals
    Inventors: Alberto Cerri, Patrizia Ferrari, Mara Ferrandi, Paolo Barassi, Giusseppe Bianchi, Shih-Che Hsu, Francesco Peri, Antonio Zaza, Marcella Rocchetti, Andrea Luraghi, Eleonora Torre, Carlotta Ronchi