Abstract: Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.
Type:
Grant
Filed:
January 5, 2024
Date of Patent:
October 29, 2024
Assignee:
Seismic Therapeutic, Inc.
Inventors:
Nathan Higginson-Scott, Nathan Rollins, Jordan Anderson, Alex Pellerin, Ryan Peckner, Yi Xing, Ivan Mascanfroni, Kevin Lewis Otipoby, Yanfeng Zhou
Abstract: Embodiments provided herein, provide for polypeptides and molecules comprising a polypeptide having protease activity and a variant Fc molecule, pharmaceutical compositions comprising the same, and methods that can be used to treat disorders, such as IgG mediated disorders.
Type:
Grant
Filed:
November 17, 2023
Date of Patent:
September 17, 2024
Assignee:
SEISMIC THERAPEUTIC, INC.
Inventors:
Nathan Higginson-Scott, Nathan Rollins, Jordan Anderson, Yanfeng Zhou, Alex Pellerin, Ivan Mascanfroni
Abstract: Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.
Type:
Grant
Filed:
October 25, 2023
Date of Patent:
July 9, 2024
Assignee:
Seismic Therapeutic, Inc.
Inventors:
Yen-Lin Chen, Ryan Peckner, Nathan Higginson-Scott, Daniela Cipolletta, Yanfeng Zhou, Kevin Lewis Otipoby, Jyothsna Visweswaraiah