Patents Assigned to SELECTION BIOSCIENCE LLC
  • Patent number: 11225551
    Abstract: The present invention relates to an amphiphilic block copolymer represented by formula I, a preparation method thereof, and a nanomicelle drug delivery system formed from the copolymer and a poorly soluble drug. The amphiphilic block copolymer includes a hydrophilic chain segment, a hydrophobic chain segment, and a linker for linking the hydrophilic chain segment to the hydrophobic chain segment. The linker contains an unsaturated structure, which can enhance the interaction between the poorly soluble drug and the copolymer to improve the drug loading ability and stability of the nanomicelle. The invention also relates to a nanomicelle drug-loading system, a preparation method thereof, and the use of the nanomicelle drug-loading system for preparing medicines for treating tumors, inflammation, diabetes, central nervous system diseases, cardiovascular diseases, and psychological disorders.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: January 18, 2022
    Assignee: SELECTION BIOSCIENCE LLC
    Inventor: Fuyao Zhang
  • Patent number: 11186570
    Abstract: Disclosed are an intermediate of Eribulin and a preparation method therefor. In particular, disclosed are compounds as represented by formula II, formula III and formula V and a preparation method therefor. Ar is C1-10 alkyl substituted, alkyloxy substituted or unsubstituted aryl; R1 and R2 is an acetal protecting group or a thioacetal protecting group; R3 is hydrogen or a hydroxyl protecting group; and X is halogen or a leaving group. The preparation method therefor has the advantages of mild reaction conditions, high selectivity, easy purification, low synthesis cost and the like, being suitable for large scale production.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: November 30, 2021
    Assignee: SELECTION BIOSCIENCE LLC
    Inventors: Fuyao Zhang, Huoming Li, Xinning Zhang
  • Patent number: 11072596
    Abstract: Disclosed are a compound as shown in general formula I, a pharmaceutically acceptable salt, an isomer or a mixture thereof, and a solvate, a polymorph, a stable isotope derivative or a prodrug thereof. The compound of the present disclosure has comparatively strong PARP inhibitory activity and can be used for treating diseases associated with PARP, such as cancers and inflammatory diseases.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: July 27, 2021
    Assignee: SELECTION BIOSCIENCE LLC
    Inventors: Fuyao Zhang, Hongshun Yuan, Xiaoming Shen