Patents Assigned to Selexis SA
  • EXPRESSION SYSTEMS, RECOMBINANT CELLS AND USES THEREOF
    Publication number: 20230193341
    Abstract: A transcriptomic analysis of genes consistently upregulated in high producer clones were each evaluated for their ability to increase the production of a protein of interest. The products of these genes (metabolism influencing products (MIP)), such as actin, Erp27, Erp57, Foxa1, PPAR, Ca3, and Tagap, could be sub-categorized into different functional categories such as signaling, protein folding, cytoskeleton organization and cell survival.
    Type: Application
    Filed: October 23, 2019
    Publication date: June 22, 2023
    Applicant: Selexis SA
    Inventors: Lucille Pourcel, Audrey Berger, Valerie Le Fourn, Severine Fagete, David Calabrese, Alexandre Regamey, Nicolas Mermod, Fabien Palazzoli, Pierre-Alain Girod
  • High efficiency gene transfer and expression in mammalian cells by amultiple transfection procedure of MAR sequences
    Patent number: 9879297
    Abstract: The present invention relates to purified and isolated DNA sequences having protein production increasing activity and more specifically to the use of matrix attachment regions (MARs) for increasing protein production activity in a eukaryotic cell. Also disclosed is a method for the identification of said active regions, in particular MAR nucleotide sequences, and the use of these characterized active MAR sequences in a new multiple transfection method.
    Type: Grant
    Filed: June 28, 2012
    Date of Patent: January 30, 2018
    Assignee: SELEXIS SA
    Inventors: Mermod Nicolas, Pierre Alain Girod, Philipp Bucher, Duc-Quang Nguyen, David Calabrese, Damien Saugy, Stefania Puttini
  • HIGH EFFICIENCY GENE TRANSFER AND EXPRESSION IN MAMMALIAN CELLS BY AMULTIPLE TRANSFECTION PROCEDURE OF MAR SEQUENCES
    Publication number: 20130143264
    Abstract: The present invention relates to purified and isolated DNA sequences having protein production increasing activity and more specifically to the use of matrix attachment regions (MARs) for increasing protein production activity in a eukaryotic cell. Also disclosed is a method for the identification of said active regions, in particular MAR nucleotide sequences, and the use of these characterized active MAR sequences in a new multiple transfection method.
    Type: Application
    Filed: June 28, 2012
    Publication date: June 6, 2013
    Applicant: SELEXIS SA
    Inventors: Mermod Nicolas, Pierre Alain Girod, Philipp Bucher, Duc-Quang Nguyen, David Calabrese, Damien Saugy, Stefania Puttini
  • Matrix attachment regions and methods for use thereof
    Patent number: 7129062
    Abstract: The present invention relates to compositions and methods for transfecting eukaryotic cells with nucleic acid vectors. In particular, the invention relates to the uses of Matrix Attachment Region (MAR) elements to increase stable and transient transfection efficiency.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: October 31, 2006
    Assignee: Selexis SA
    Inventors: Nicolas Mermod, Monique Zahn-Zabal, Markus Imhof, Philippe Chatellard, Pierre-Alain Girod