Abstract: The present invention provides compositions and methods using certain GPR4-regulated genes and expression products thereof (namely YAP1, CTGF, CCND3, BDNF, VCL, ITGB3) for diagnosis, treatment and prevention of Alzheimer's disease and Mild Cognitive Impairment. The present invention also relates to a method of identifying therapeutic agents to treat and diagnose Alzheimer's disease or Mild Cognitive Impairment based on the differential expression of GPR4-regulated genes.
Abstract: The present invention provides compositions and methods using SNCA-mediated genes and expression products thereof for diagnosis, treatment and prevention of Parkinson's disease. The present invention also relates to a method of identifying therapeutic agents to treat and diagnose Parkinson's disease based on SNCA-mediated genes.