Patents Assigned to Sembiosys Genetics Inc.
  • Patent number: 6761914
    Abstract: The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the vaccines and the use of the vaccines to elicit an immune response.
    Type: Grant
    Filed: June 15, 2001
    Date of Patent: July 13, 2004
    Assignee: SemBioSys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney, Anthony B. Schryvers, Joenel Alcantara, Wendy A. Hutchins
  • Patent number: 6753167
    Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oil body proteins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.
    Type: Grant
    Filed: June 29, 2001
    Date of Patent: June 22, 2004
    Assignee: SemBioSys Genetics Inc.
    Inventors: Maurice M. Moloney, Gijs van Rooijen
  • Patent number: 6750046
    Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides include thioredoxin and/or thioredoxin reductase. The invention can also be modified to recover recombinant polypeptides fused to oil body proteins from non-plant host cells.
    Type: Grant
    Filed: July 3, 2001
    Date of Patent: June 15, 2004
    Assignee: Sembiosys Genetics, Inc.
    Inventors: Maurice M. Moloney, Bipin K. Dalmia
  • Publication number: 20030177537
    Abstract: The present invention provides a method of preparing epidermal growth factors in plants and transgenic plant seeds containing epidermal growth factors. The method provides an economical way to produce epidermal growth factors.
    Type: Application
    Filed: December 20, 2002
    Publication date: September 18, 2003
    Applicant: SemBioSys Genetics Inc.
    Inventors: Maurice M. Moloney, Gijs Van Rooijen
  • Publication number: 20030166162
    Abstract: An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions.
    Type: Application
    Filed: December 19, 2002
    Publication date: September 4, 2003
    Applicant: SemBioSys Genetics Inc.
    Inventors: Gijs Van Rooijen, Joenel Alcantara, Maurice M. Moloney
  • Patent number: 6599513
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
    Type: Grant
    Filed: October 24, 2001
    Date of Patent: July 29, 2003
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Patent number: 6582710
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
    Type: Grant
    Filed: January 29, 2002
    Date of Patent: June 24, 2003
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Publication number: 20030096320
    Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.
    Type: Application
    Filed: October 1, 2002
    Publication date: May 22, 2003
    Applicant: SemBioSys Genetics Inc.
    Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
  • Publication number: 20030059910
    Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.
    Type: Application
    Filed: October 1, 2002
    Publication date: March 27, 2003
    Applicant: SemBioSys Genetics Inc.
    Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
  • Patent number: 6509453
    Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein.
    Type: Grant
    Filed: August 27, 1999
    Date of Patent: January 21, 2003
    Assignee: SemBioSys Genetics Inc.
    Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
  • Publication number: 20020114820
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
    Type: Application
    Filed: January 29, 2002
    Publication date: August 22, 2002
    Applicant: SemBioSys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Patent number: 6372234
    Abstract: The present invention provide novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.
    Type: Grant
    Filed: May 24, 2000
    Date of Patent: April 16, 2002
    Assignee: SemBioSys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Patent number: 6288304
    Abstract: The present invention provides a method of preparing somatotropins in plants and transgenic plant seeds containing somatotropins. The method provides an economical way to produce somatotropins.
    Type: Grant
    Filed: December 18, 1998
    Date of Patent: September 11, 2001
    Assignee: SemBioSys Genetics Inc.
    Inventors: Maurice M. Moloney, Hamid R. Habibi
  • Patent number: 6210742
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: April 3, 2001
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Soheil Mahmoud, Maurice M. Moloney
  • Patent number: 6183762
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
    Type: Grant
    Filed: November 24, 1999
    Date of Patent: February 6, 2001
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
  • Patent number: 6146645
    Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.
    Type: Grant
    Filed: May 27, 1998
    Date of Patent: November 14, 2000
    Assignee: Sembiosys Genetics Inc.
    Inventors: Harm M Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Soheil Mahmoud, Maurice M. Moloney
  • Patent number: 5948682
    Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oil body proteins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.
    Type: Grant
    Filed: April 25, 1997
    Date of Patent: September 7, 1999
    Assignee: Sembiosys Genetics Inc.
    Inventor: Maurice M. Moloney
  • Patent number: 5856452
    Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.
    Type: Grant
    Filed: December 16, 1996
    Date of Patent: January 5, 1999
    Assignee: Sembiosys Genetics Inc.
    Inventors: Maurice Moloney, Gijs van Rooijen, Joseph Boothe
  • Patent number: 5792922
    Abstract: DNA constructs comprising 5' untranslated sequences from genes active from the late globular stage through to embryo maturity are provided. These constructs may be used to obtain expression of a DNA sequence of interest during phases of embryogenesis which precede the accumulation of storage proteins.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: August 11, 1998
    Assignee: Sembiosys Genetics Inc.
    Inventor: Maurice M. Moloney
  • Patent number: 5650554
    Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oleosins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: July 22, 1997
    Assignee: SemBioSys Genetics Inc.
    Inventor: Maurice Moloney