Patents Assigned to Sembiosys Genetics Inc.
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Patent number: 6761914Abstract: The present invention provides novel adjuvants which comprise oil bodies. The invention also provides vaccine formulations comprising oil bodies and an antigen and methods for preparing the vaccines and the use of the vaccines to elicit an immune response.Type: GrantFiled: June 15, 2001Date of Patent: July 13, 2004Assignee: SemBioSys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney, Anthony B. Schryvers, Joenel Alcantara, Wendy A. Hutchins
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Patent number: 6753167Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oil body proteins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.Type: GrantFiled: June 29, 2001Date of Patent: June 22, 2004Assignee: SemBioSys Genetics Inc.Inventors: Maurice M. Moloney, Gijs van Rooijen
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Patent number: 6750046Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides include thioredoxin and/or thioredoxin reductase. The invention can also be modified to recover recombinant polypeptides fused to oil body proteins from non-plant host cells.Type: GrantFiled: July 3, 2001Date of Patent: June 15, 2004Assignee: Sembiosys Genetics, Inc.Inventors: Maurice M. Moloney, Bipin K. Dalmia
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Publication number: 20030177537Abstract: The present invention provides a method of preparing epidermal growth factors in plants and transgenic plant seeds containing epidermal growth factors. The method provides an economical way to produce epidermal growth factors.Type: ApplicationFiled: December 20, 2002Publication date: September 18, 2003Applicant: SemBioSys Genetics Inc.Inventors: Maurice M. Moloney, Gijs Van Rooijen
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Publication number: 20030166162Abstract: An improved method for recovering recombinantly produced polypeptides is described. The method involves expressing the recombinant polypeptide as a fusion protein with a pro-peptide. The pro-peptide-polypeptide fusion protein can be cleaved and the recombinant polypeptide released under the appropriate conditions.Type: ApplicationFiled: December 19, 2002Publication date: September 4, 2003Applicant: SemBioSys Genetics Inc.Inventors: Gijs Van Rooijen, Joenel Alcantara, Maurice M. Moloney
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Patent number: 6599513Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: GrantFiled: October 24, 2001Date of Patent: July 29, 2003Assignee: Sembiosys Genetics Inc.Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Patent number: 6582710Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: GrantFiled: January 29, 2002Date of Patent: June 24, 2003Assignee: Sembiosys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Publication number: 20030096320Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: ApplicationFiled: October 1, 2002Publication date: May 22, 2003Applicant: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Publication number: 20030059910Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: ApplicationFiled: October 1, 2002Publication date: March 27, 2003Applicant: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Patent number: 6509453Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein.Type: GrantFiled: August 27, 1999Date of Patent: January 21, 2003Assignee: SemBioSys Genetics Inc.Inventors: Maurice Moloney, Joseph Boothe, Gijs Van Rooijen
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Publication number: 20020114820Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: ApplicationFiled: January 29, 2002Publication date: August 22, 2002Applicant: SemBioSys Genetics Inc.Inventors: Harm M. Deckers, Gijs Van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Patent number: 6372234Abstract: The present invention provide novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild to the skin and may be easily formulated into a wide variety of personal care and dermatological products.Type: GrantFiled: May 24, 2000Date of Patent: April 16, 2002Assignee: SemBioSys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Patent number: 6288304Abstract: The present invention provides a method of preparing somatotropins in plants and transgenic plant seeds containing somatotropins. The method provides an economical way to produce somatotropins.Type: GrantFiled: December 18, 1998Date of Patent: September 11, 2001Assignee: SemBioSys Genetics Inc.Inventors: Maurice M. Moloney, Hamid R. Habibi
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Patent number: 6210742Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.Type: GrantFiled: July 5, 2000Date of Patent: April 3, 2001Assignee: Sembiosys Genetics Inc.Inventors: Harm M Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Soheil Mahmoud, Maurice M. Moloney
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Patent number: 6183762Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.Type: GrantFiled: November 24, 1999Date of Patent: February 6, 2001Assignee: Sembiosys Genetics Inc.Inventors: Harm M. Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Maurice M. Moloney
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Patent number: 6146645Abstract: The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in various domestic and industrial compositions. The emulsions are especially suited for the preparation of food products, personal care products, pharmaceutical products and industrial products.Type: GrantFiled: May 27, 1998Date of Patent: November 14, 2000Assignee: Sembiosys Genetics Inc.Inventors: Harm M Deckers, Gijs van Rooijen, Joseph Boothe, Janis Goll, Soheil Mahmoud, Maurice M. Moloney
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Patent number: 5948682Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oil body proteins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.Type: GrantFiled: April 25, 1997Date of Patent: September 7, 1999Assignee: Sembiosys Genetics Inc.Inventor: Maurice M. Moloney
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Patent number: 5856452Abstract: A method for the separation of a target molecule from a mixture is described. The method employs oil bodies and their associated proteins as affinity matrices for the selective, non-covalent binding of desired target molecules. The oil body proteins may be genetically fused to a ligand having specificity for the desired target molecule. Native oil body proteins can also be used in conjunction with an oil body protein specific ligand such as an antibody or an oil body binding protein. The method allows the separation and recovery of the desired target molecules due to the difference in densities between oil bodies and aqueous solutions.Type: GrantFiled: December 16, 1996Date of Patent: January 5, 1999Assignee: Sembiosys Genetics Inc.Inventors: Maurice Moloney, Gijs van Rooijen, Joseph Boothe
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Patent number: 5792922Abstract: DNA constructs comprising 5' untranslated sequences from genes active from the late globular stage through to embryo maturity are provided. These constructs may be used to obtain expression of a DNA sequence of interest during phases of embryogenesis which precede the accumulation of storage proteins.Type: GrantFiled: January 27, 1995Date of Patent: August 11, 1998Assignee: Sembiosys Genetics Inc.Inventor: Maurice M. Moloney
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Patent number: 5650554Abstract: The present invention relates to the use of a class of genes called oil body protein genes that have unique features. The discovery of these features allowed the invention of methods for the production of recombinant proteins wherein a protein of interest can be easily separated from other host cell components. The invention is further exemplified by methods for exploitation of the unique characteristics of the oil body proteins and oil body genes for expression of polypeptides of interest in many organisms, particularly plant seeds. Said polypeptides may include but are not limited to: seed storage proteins, enzymes, bioactive peptides, antibodies and the like. The invention can also be modified to recover recombinant polypeptides fused to oleosins from non-plant host cells. Additionally the invention provides a method of using recombinant proteins associated with seed oil bodies released during seed germination for expression of polypeptides that afford protection to seedlings from pathogens.Type: GrantFiled: December 30, 1994Date of Patent: July 22, 1997Assignee: SemBioSys Genetics Inc.Inventor: Maurice Moloney