Abstract: Substrates, optionally coated with an undercoating layer, having grafted there from one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted from a variety of substrate materials, particularly polymeric substrates and/or polymeric undercoating layers. The graft-from techniques described herein can result in higher surface densities of the non-fouling material relative to graft-to formulations. Graft-from methods can be used to produce covalently tethered polymers. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity.

Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Abstract: Catheters and a method for preparation thereof, the catheter comprising as component parts thereof a catheter body, a juncture hub, at least one extension line and at least one connector, each of said component parts comprising an exterior surface, at least one lumen having an intraluminal surface and a bulk polymer, wherein the intraluminal or external surface of a first of said component parts and the exterior or intraluminal surface of a second of said component parts comprise a hydrophilic polymer layer thereon having an Average Dry Thickness of at least about 50 nanometers and the first and second component parts comprise bulk polymers having different chemical compositions

Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Abstract: Medical devices having a wettable, biocompatible surface are described herein. Processes for producing such devices are also described.

Abstract: Catheters and a method of preparation thereof, the catheter comprising a catheter body, a juncture hub, extension lines and connectors, the catheter body having a proximal end, a distal end, an exterior surface, a tip region having a length of 10 cm measured from the distal end of the catheter body, and at least two lumen, each of the catheter body lumen having a proximal end, a distal end, a Lumen Aspect Ratio of at least 3:1, and an intraluminal surface, the distal ends of the at least two catheter body lumen being (i) non-coterminus or (ii) laser-cut, the exterior surface of the catheter body in the tip region or the intraluminal surface of the two catheter body lumen comprising a hydrophilic polymer layer having an Average Dry Thickness of at least about 50 nanometers.

Abstract: Catheters and a method of preparation thereof comprising a catheter body and at least one connector. The catheter body has an exterior surface and at least one lumen having an aspect ratio of at least 3:1 and an intraluminal surface comprising a hydrophilic polymer layer thereon, the hydrophilic polymer layer has an average dry thickness of at least about 50 nanometers.

Abstract: Substrates, optionally coated with an undercoating, having grafted thereto one or more non-fouling materials are described herein. The non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate. The compositions described herein are highly resistant protein absorption, particularly in complex media and retain a high degree of non-fouling activity over long periods of time. The compositions described herein may also demonstrate antimicrobial and/or anti-thrombogenic activity. The non-fouling material can be grafted to a functionalized substrate, or optionally from an undercoating on the substrate, preferably without significantly affecting the mechanical and/or physical properties of the substrate material.