Abstract: The present invention relates to stable pharmaceutical liquid formulations of the fusion protein TNFR:Fc comprising different buffer systems and stabilizers. In particular, it could be demonstrated that the physical stability of TNFR:Fc is significantly improved by using a citrate buffer system and lysine as stabilizer.
Type:
Application
Filed:
April 19, 2012
Publication date:
July 3, 2014
Applicant:
SENDOZ AG
Inventors:
Deutel Britta, Thomas Lauber, Sabine Fuertinger