Patents Assigned to SENECA THERAPEUTICS, INC.
  • SECOND GENERATION SENECA VALLEY VIRUS ONCOLYTIC THERAPY: COMPOSITIONS AND METHODS THEREOF
    Publication number: 20220249584
    Abstract: Provided herein are compositions and methods of using Seneca Valley Virus (SVV) or a derivative thereof and an interferon type I (IFN-I) inhibiting agent comprising an mTOR inhibitor for treating a cancer in a subject. The disclosed methods particularly rely upon the expression level of an ANTXR1 and the expression level of IFN-I in the cancer from the subject. Also provided herein are methods for predicting the efficacy of an SVV treatment comprising IFN-I inhibiting agent.
    Type: Application
    Filed: July 20, 2020
    Publication date: August 11, 2022
    Applicants: SENECA THERAPEUTICS, INC., THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
    Inventors: Vincent R. RACANIELLO, Amy B. ROSENFELD, Paul L. HALLENBECK
  • COMPOSITIONS AND METHODS OF USING SENECA VALLEY VIRUS (SVV) FOR TREATING CANCER
    Publication number: 20220202884
    Abstract: Provided herein are compositions and methods of using Seneca Valley Virus (SW), or a derivative thereof, combined with an IFN-I inhibitor for treating a cancer in a subject. The disclosed methods particularly rely upon the expression level of an ANTXR1 and the expression level of IFN-I in the cancer from the subject. Also provided herein are methods for predicting the efficacy of an SW treatment and a kit for determining the same.
    Type: Application
    Filed: April 10, 2020
    Publication date: June 30, 2022
    Applicant: SENECA THERAPEUTICS, INC.
    Inventor: Paul L. HALLENBECK