Patents Assigned to Senesco Technologies, Inc.
  • Use of Apoptosis-Specific elF-5A siRNA to Down Regulate Expression of Proinflammatory Cytokines to Treat Sepsis
    Publication number: 20140371299
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.
    Type: Application
    Filed: September 2, 2014
    Publication date: December 18, 2014
    Applicant: Senesco Technologies, Inc.
    Inventors: JOHN E. THOMPSON, CATHERINE TAYLOR, CHARLES A. DINARELLO
  • Use Of siRNA To Achieve Down Regulation Of An Endogenous Gene In Combination With The Use of A Sense Construct To Achieve Expression Of A Polynucleotide
    Publication number: 20140296320
    Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.
    Type: Application
    Filed: February 26, 2014
    Publication date: October 2, 2014
    Applicant: SENESCO TECHNOLOGIES, INC.
    Inventors: Richard S. Dondero, John E. Thompson, Catherine A. Taylor
  • Nucleic Acids, Polypetides, and Methods for Modulating Apoptosis
    Publication number: 20140212969
    Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific and DHS useful in such methods.
    Type: Application
    Filed: October 11, 2013
    Publication date: July 31, 2014
    Applicant: Senesco Technologies, Inc.
    Inventors: Catherine Taylor, Tzann-Wei Wang, Larry Petrov, John C. Carlson, Richard Narayansingh, John E. Thompson
  • Isolated eIF-5A and Polynucleotides Encoding Same
    Publication number: 20140182014
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Application
    Filed: October 11, 2013
    Publication date: June 26, 2014
    Applicant: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Tzann-Wei Wang
  • Inhibition of apoptosis-specific eIF-5A(eIF-5A1?) with antisense oligonucleotides and siRNA as anti-inflammatory therapeutics
    Patent number: 8754057
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
    Type: Grant
    Filed: May 2, 2011
    Date of Patent: June 17, 2014
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Bruce C. Galton, Catherine Taylor, Charles Dinarello, Leonid Reznikov, Adrienne Boone, Marianne Hopkins
  • Compositions comprising siRNA and plasmids
    Patent number: 8703929
    Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.
    Type: Grant
    Filed: March 9, 2009
    Date of Patent: April 22, 2014
    Assignee: Senesco Technologies, Inc.
    Inventors: Richard S. Dondero, John E. Thompson, Catherine A. Taylor
  • Transgenic Algae with Enhanced Oil Expression
    Publication number: 20130280770
    Abstract: The present invention provides transgenic algal cells that produce an increased amount of oil, methods of making transgenic algal cells, and methods of obtaining biofuel from the transgenic algal cells.
    Type: Application
    Filed: April 22, 2011
    Publication date: October 24, 2013
    Applicant: Senesco Technologies, Inc.
    Inventors: Holly Loucas, Tzann-wei Wang, John Thompson
  • Isoforms of eIF-5A: senescence-induced eIF5A; wounding-induced eIF-5A; growth eIF-5A; and DHS
    Patent number: 8563285
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: October 22, 2013
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Tzann-Wei Wang, Dongen Lily Lu
  • Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells
    Patent number: 8445638
    Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide. The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: May 21, 2013
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Zhong Sun, Catherine A. Taylor, Richard Dondero, Zhenyu Cheng
  • siRNA useful to supress expression of EIF-5A1
    Patent number: 8242256
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: August 14, 2012
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Bruce C. Galton, Catherine Taylor, Adrienne Boone, Elizabeth Heikkila, Dominic Cliche, Shelley Culp-Stewart, John Gerard Flanagan, Michelle Senchyna
  • Polynucleotides encoding canola DHS and antisense polynucleotides thereof
    Patent number: 8232455
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding-induced eIF-5A; and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Grant
    Filed: February 5, 2008
    Date of Patent: July 31, 2012
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Tzann-Wei Michael Wang
  • Use of apoptosis-specific eIF-5A siRNA to down regulate expression of proinflammatory cytokines to treat sepsis
    Patent number: 8193158
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5-A1, nucleic acids and polypeptides and methods for down regulating pro-inflammatory cytokines in a mammal by administering siRNA against eIF-5A1 to the mammal to treat/prevent sepsis and/or hemorrhagic shock.
    Type: Grant
    Filed: March 20, 2007
    Date of Patent: June 5, 2012
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Charles A. Dinarello
  • Inhibition of Apoptosis-Specific eIF-5A(elF-5A1") with Antisense Oligonucleotides and siRNA as Anti-Inflammatory Therapeutics
    Publication number: 20120129910
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis-specific eIF-5A or eIF5A1, nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of apoptosis-specific eIF-5A. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines or inhibiting activation of NFkB by inhibiting expression of apoptosis-specific eIF-5A.
    Type: Application
    Filed: May 2, 2011
    Publication date: May 24, 2012
    Applicant: Senesco Technologies Inc.
    Inventors: John E. Thompson, Bruce C. Galton, Catherine Taylor, Charles Dinarello, Leonid Reznikov, Adrienne Boone, Marianne Hopkins
  • Method for inducing apoptosis using apoptosis-specific EIF5-A
    Patent number: 7968523
    Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: June 28, 2011
    Assignee: Senesco Technologies, Inc.
    Inventors: Catherine Taylor, Tzann-Wei Wang, Larry Petrov, John C. Carlson, Richard Narayansingh, John E. Thompson, Dominic O. Cliche, Marianne Hopkins
  • SiRNA Useful to Suppress expression of eIF-5A1
    Publication number: 20110098460
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
    Type: Application
    Filed: December 17, 2009
    Publication date: April 28, 2011
    Applicant: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Bruce C. Galton, Catherine Taylor, Adrienne Boone, Elizabeth Heikkila, Dominic Cliche, Shelley Culp-Stewart, John Gerard Flanagan, Michelle Senchyna
  • Expression vector encoding apoptosis-specific eIF-5A
    Patent number: 7872112
    Abstract: The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific eIF-5A and DHS useful in such methods.
    Type: Grant
    Filed: November 13, 2006
    Date of Patent: January 18, 2011
    Assignee: Senesco Technologies, Inc.
    Inventors: Catherine A. Taylor, Tzann-Wei Wang, Larry Petrov, John C. Carlson, Richard Narayansingh, Marianne Kaup, Dominic Cliche, John E. Thompson
  • Cottonwood Growth eIF-5A
    Publication number: 20100333233
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding/pathogen induced eIF-5A; stress eIF-5A and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Application
    Filed: December 14, 2009
    Publication date: December 30, 2010
    Applicant: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Tzann-Wei Wang, Linda Nowack, Wendy Wu
  • Use of a Truncated eIF-5A1 Polynucleotide to Induce Apoptosis in Cancer Cells
    Publication number: 20100076062
    Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide. The present invention also relates to a truncated form of eIF-5A1 that is useful for inducing apoptosis and killing of cells, especially cancer cells in a mammal.
    Type: Application
    Filed: September 2, 2009
    Publication date: March 25, 2010
    Applicant: SENESCO TECHNOLOGIES, INC.
    Inventors: John E. THOMPSON, Zhong SUN, Catherine TAYLOR, Richard DONDERO, Zhenyu CHENG
  • Use of antisense oligonucleotides or siRNA to suppress expression of eIF-5A1
    Patent number: 7662796
    Abstract: The present invention relates to apoptosis specific eucaryotic initiation factor 5A (eIF-5A), referred to as apoptosis factor 5A1 or simply factor 5A1, apoptosis factor 5A1 nucleic acids and polypeptides and methods for inhibiting or suppressing apoptosis in cells using antisense nucleotides or siRNAs to inhibit expression of factor 5A1. The invention also relates to suppressing or inhibiting expression of pro-inflammatory cytokines by inhibiting expression of apoptosis factor 5A.
    Type: Grant
    Filed: November 28, 2005
    Date of Patent: February 16, 2010
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Bruce C. Galton, Catherine Taylor, Adrienne Boone, Elizabeth Heikkila, Dominic Cliche, Shelley Culp-Stewart, John Gerard Flanagan, Michelle Senchyna
  • Method of increasing seed yield and growth eIF-5A
    Patent number: 7663028
    Abstract: The present invention relates to unique isoforms of eukaryotic initiation Factor 5A (“eIF-5A”): senescence-induced eIF-5A; wounding/pathogen induced eIF-5A; stress eIF-5A and growth eIF-5A, as well as polynucleotides that encode these three factors. The present invention also relates to methods involving modulating the expression of these factors. The present invention also relates to deoxyhypusine synthase (“DHS”), polynucleotides that encode DHS, and methods involving modulating the expression of DHS.
    Type: Grant
    Filed: December 5, 2005
    Date of Patent: February 16, 2010
    Assignee: Senesco Technologies, Inc.
    Inventors: John E. Thompson, Tzann-Wei Wang, Linda Nowack, Wendy Wu