Abstract: The invention relates to novel compounds useful in the treatment and prophylaxis of disease. Compounds of the formula (I) wherein X is halogen, independently selected form chlorine and fluorine and n is 0, 1 or 2, and their pharmaceutically acceptable salts are useful in the treatment and prophylaxis of diseases caused by activation of microglia, particularly Alzheimer's disease.

Abstract: The invention relates to novel compounds useful in the treatment and prophylaxis of disease. Compounds of the formula (I): wherein X is halogen, independently selected form chlorine and fluorine and their pharmaceutically acceptable salts are useful in the treatment and prophylaxis of diseases caused by activation of microglia, particularly Alzheimer's disease.

Abstract: a compound of formula (I) or a pharmaceutically acceptable salt or prodrug thereof: wherein X and Y are independently NR5 or O; W and Z are independently a bond or (CH2)mCH(R7)(CH2)n; m=0-1, n=0-2; R is hydrogen or halogen; R1 and R2 are independently selected from hydrogen halogen, CF3, CN, OR8, NR9R10, NR9COR11, NR9SO2R11 or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R3 is hydrogen, halogen, CF3, CN, OR8, SR8 or SO2R11; R4 is hydrogen, halogen, CF3, OR9, NR9R10, NR9COR11, NR9SO2R11 or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R5 is hydrogen or C1-6 alkyl optionally substituted by hydroxyl, C1-6 alkoxy or NR9R10; R6 is hydrogen, fluorine, C1-6 alkyl, or C1-6 alkoxy; R6 is hydrogen, fluorine, C1-6 alkyl, or C1-6 alkoxy; R7 is hydrogen, C1-6 alkyl, phenyl or C1-3 alkylphenyl wherein said phenyl groups are optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, CF3, OCF3 or OR9; R8 is hydrogen or C1-6 alkyl optionally substitut

Abstract: The present invention provides (I) These compounds are useful in prevention and treatment of neurodegenerative disorders, such as Alzheimer's, Parkinson's and Huntington's as well as type II diabetes.

Abstract: Peptide is disclosed which is capable of binding to ?-strand in a separate peptide-containing molecule to form ?-sheet, wherein said peptide is selectively N?-substituted in one edge (first) of the ?-strand-forming section of said peptide while the other edge (second) in the opposite orientation to the first edge in view of peptide backbone plane remains N?-unsubstituted. Such the N?-substituted peptide is capable of preventing association of said peptide with other ?-strand (target) but permits interaction of said peptide with target ?-strand in separate peptide-containing molecules through the N?-unsubstituted edge.

Abstract: Peptide is disclosed which comprises D-enantiomers of amino acids and is capable of interacting with other ?-strand structure to form ?-sheet, wherein said peptide is selectively N?-substituted in one edge (first) of the ?-strand-forming section of said peptide while the other edge (second) in the opposite orientation to the first edge in view of peptide backbone plane remains N?-unsubstituted. Such the N?-substituted peptide is capable of preventing association of said peptide with other ?-strand (target) but permits interaction of said peptide with target ?-strand in separate peptide-containing molecules through the N?-unsubstituted edge. The peptide is useful for preventing ?-strand association or aggregation.