Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits for use in said methods. The methods employ nicking agent(s), polymerase and oligonucleotide probes to produce probe fragments in the presence of a target nucleic acid.
Type:
Grant
Filed:
January 25, 2018
Date of Patent:
February 28, 2023
Assignee:
Sense Biodetection Limited
Inventors:
Henry John Lamble, David Lloyd, Christopher Egan
Abstract: The present invention is directed to kits and methods for detecting and discriminating the target pathogens Influenza A Virus and Influenza B Virus and optionally Respiratory Syncytial Virus in a sample and to devices containing said kits and for use in said methods. The invention employs restriction enzymes, polymerase and oligonucleotide primers to produce, in the presence of a target pathogen, an amplification product which is contacted with oligonucleotide probes to produce a detector species.
Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence, and compositions and kits for use in said methods. The methods employ nicking agent(s) and a sequential series of oligonucleotide probes to produce probe fragments in the presence of a target nucleic acid.
Type:
Grant
Filed:
July 22, 2016
Date of Patent:
July 19, 2022
Assignee:
Sense Biodetection Limited
Inventors:
Henry John Lamble, Christopher Egan, David Lloyd, Eryk Dunski
Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence and kits for use in said methods. The methods employ nicking agent(s), polymerase and oligonucleotide probes to produce probe fragments in the presence of a target nucleic acid.
Type:
Application
Filed:
January 25, 2018
Publication date:
January 2, 2020
Applicant:
Sense Biodetection Limited
Inventors:
Henry John Lamble, David Lloyd, Christopher Egan
Abstract: The present invention relates to methods for the detection of nucleic acids of defined sequence, and compositions and kits for use in said methods. The methods employ nicking agent(s) and a sequential series of oligonucleotide probes to produce probe fragments in the presence of a target nucleic acid.
Type:
Application
Filed:
July 22, 2016
Publication date:
August 2, 2018
Applicant:
Sense Biodetection Limited
Inventors:
Henry John Lamble, Christopher Egan, David Lloyd, Eryk Dunski