Abstract: A drug reconstitution device comprising a disposable liquid transfer unit (18) and a reusable control and drive unit (16) removably connectable to the liquid transfer unit, the liquid transfer unit including a housing (26), a docking interface (30) configured for coupling at least one of the first and second constituent containers (2, 4) to the housing (10), and a pump engine (28) and fluid flow system (36) configured for transferring liquid from the first constituent container (2) to the second constituent container (4). The control and drive unit comprises a pump drive (22) configured to drive the pump engine during a liquid transfer action, the pump drive comprising a transmission output coupling (34) removably engaged with a transmission input coupling (50) of the pump engine (28) when the liquid transfer unit and control and drive unit are connected.

Abstract: A manually energized dispensing system containing a dispensing head (1) which has a housing (2), a nozzle, a pump (4) mounted in the housing, and a pump actuation mechanism (3) is provided. The pump has a pump rotor (13) and a stator (12). The pump rotor has two axial extensions (17, 18) of different diameters, mounted in corresponding chambers (15, 16) of the stator, and first and second seals (19, 20) mounted in the stator housing and surrounding the first and second axial rotor extensions. The rotor extensions comprising liquid supply channels (22, 24), in conjunction with the seals operate as valves that open and close communication between an inlet of the pump connected to the inside of a container (7) and the pump chambers, respectively. The pump chambers are operated as a function of the angular displacement of the pump rotor.

Abstract: A pump comprising a housing comprising a rotor chamber, inlet and outlet channels opening into the rotor chamber, and inlet and outlet seals mounted on a surface of the chamber, and a rotor rotatably and axially slidably received in the chamber and comprising a first axial extension comprising a liquid supply channel and a second axial extension comprising a liquid supply channel, the first and second axial extensions having different diameters. The inlet and outlet seals engage a surface of the rotor, whereby the liquid supply channel of each axial extension in conjunction with a corresponding seal forms a valve that opens and closes as a function of the angular and axial displacement of the rotor. At least one of the inlet and outlet channels opens transversely into the rotor chamber and at least one of the inlet and outlet seals forms a closed circuit circumscribing said at least one of the inlet and outlet channels.

Abstract: A pump comprising an electrical motor drive (2) and a pump engine (3), the pump engine having a stator portion (32) and an axially and rotatably movable rotor portion (30) mounted in the stator portion. The electrical motor drive comprises a rotor (6) with a permanent magnet (20), a stator (4) with a magnetic circuit (10) and one or more coils, and a position sensor (8) comprising at least one magnetic field detector (24a, 24b) positioned in the proximity of the rotor permanent magnet and configured to detect both rotational and axial movement of the rotor.

Abstract: A manually energized dispensing system for dispensing a fluid (8) contained in a non-pressurized container (7). The dispensing system comprises a dispensing head (1) comprising a housing (2), a nozzle through which fluid to be dispensed exits, a pump (4) mounted in the housing, and a pump actuation mechanism (3), the pump comprising a rotor (13) rotatably and axially displaceable with respect to a stator (12).

Abstract: There provided a drug delivery device adapted for providing a plurality of discrete doses of a medicament including a disposable delivery unit (2) adapted to be worn by a user, comprising a reservoir (10b) for holding a medicament to be delivered, an injection member (22) adapted for trans-dermal drug delivery, and a pump (12) adapted for pumping the medicament to be delivered from the reservoir (10b) to the injection member (22); and a separate reusable base unit (4) comprising a drive module for driving the pump (12). The pump in the disposable delivery unit is activated to deliver a dose of the medicament by bringing the base unit temporarily into communication with the delivery unit.

Abstract: There is provided a selectively permeable biointerface membrane, permitting selective diffusion of analyte therethrough, for use in an analyte sensor comprising a nanoporous substrate and a coating, on the nanoporous substrate, comprising a plurality of polymer chains whereby each polymer chain is attached at one chain end thereof to a surface of the nanoporous substrate. There are also provided methods for the preparation of the selectively permeable membrane and an analyte sensor comprising the membrane.

Abstract: A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.

Abstract: A pump comprising a housing comprising a rotor chamber, inlet and outlet channels opening into the rotor chamber, and inlet and outlet seals mounted on a surface of the chamber, and a rotor rotatably and axially slidably received in the chamber and comprising a first axial extension comprising a liquid supply channel and a second axial extension comprising a liquid supply channel, the first and second axial extensions having different diameters. The inlet and outlet seals engage a surface of the rotor, whereby the liquid supply channel of each axial extension in conjunction with a corresponding seal forms a valve that opens and closes as a function of the angular and axial displacement of the rotor. At least one of the inlet and outlet channels opens transversely into the rotor chamber and at least one of the inlet and outlet seals forms a closed circuit circumscribing said at least one of the inlet and outlet channels.

Abstract: A pump including a stator, a rotor comprising an axial extension slidably and rotatably mounted at least partially in a rotor chamber of the stator, and at least first and second valves between an inlet and the rotor chamber, respectively between the rotor chamber and an outlet, that open and close as, a function of at least the angular displacement of the rotor. The pump comprises interacting cam elements on the rotor and stator and biasing elements acting on the rotor for applying a force on the rotor in the axial direction of the stator cam elements.

Abstract: A cartridge (2) with a fill level detection system (10, 10?, 10?), the cartridge comprising a substantially rigid containing wall (4) having a tubular wall portion (12) surrounding a chamber (18) for receiving liquid therein, a plunger or piston (8) mounted inside the chamber and configured to seal one side of the chamber, the plunger or piston being displaceable in the chamber towards an outlet end (14) of the cartridge, characterized in that the fill level detection system comprises a plurality of discrete fixed electrodes (24, 24?) positioned along the tubular wall portion in a juxtaposed manner in a direction of displacement D of the plunger or piston (8), and a mobile electrode member (28) fixed to the plunger or piston and displaceable therewith.

Abstract: There is provided a glucose responsive membrane comprising a nanoporous support substrate and a coating of a glucose responsive hydrogel attached to a surface of the nanoporous substrate. There are also provided methods for the preparation of the glucose responsive membrane and a medical device for the monitoring or regulation of glucose levels in a patient comprising the membrane.

Abstract: A pump comprising an electrical motor drive (2) and a pump engine (3), the pump engine having a stator portion (32) and an axially and rotatably movable rotor portion (30) mounted in the stator portion. The electrical motor drive comprises a rotor (6) with a permanent magnet (20), a stator (4) with a magnetic circuit (10) and one or more coils, and a position sensor (8) comprising at least one magnetic field detector (24a, 24b) positioned in the proximity of the rotor permanent magnet and configured to detect both rotational and axial movement of the rotor.

Abstract: There is provided a medical device for measuring an analyte concentration in the subcutaneous tissue of a patient, the medical device comprising a body access unit and a processing unit. The body access unit and the processing unit are functionally connected when an analyte concentration is measured. The body access unit comprises a transcutaneous dialysis member for accessing the body of a patient. A fluid reservoir is contained at least partially in the transcutaneous dialysis member, and the fluid reservoir is at least partially bounded by a porous membrane. The fluid reservoir contains an analyte sensitive liquid. The processing unit comprises an excitation means adapted to act on a displacement member of the body access unit to generate a flow of the analyte sensitive liquid in the fluid reservoir.

Abstract: There provided a drug delivery device adapted for providing a plurality of discrete doses of a medicament including a disposable delivery unit (2) adapted to be worn by a user, comprising a reservoir (10b) for holding a medicament to be delivered, an injection member (22) adapted for trans-dermal drug delivery, and a pump (12) adapted for pumping the medicament to be delivered from the reservoir (10b) to the injection member (22); and a separate reusable base unit (4) comprising a drive module for driving the pump (12). The pump in the disposable delivery unit is activated to deliver a dose of the medicament by bringing the base unit temporarily into communication with the delivery unit.

Abstract: A liquid flow sensing system comprises a pump system configured to deliver a pre-determined volume V of liquid, and a measuring system comprising a chamber connected to the pump system and to an outlet system, the chamber bounded by an elastic membrane configured to be displaced elastically by an amplitude that enables said pre-determined volume V of liquid to be injected in the chamber. The measuring system further comprises a membrane displacement sensor configured to measure at least a portion of a decay characteristic of said membrane displacement amplitude after injection of the pre-determined volume V, into a value that may be used for determining absolute or relative viscosity of the liquid or changes in flow resistance downstream of the sensing system or for determining the presence of gas bubbles in a liquid flow circuit.

Abstract: A medical device comprising a pressure generating means adapted to deliver a liquid, a sensor adapted to measure a flow resistance, and an implantable member comprising an analyte responsive porous membrane which reversibly changes its porosity subject to changes in analyte concentration occurring in the solution surrounding the implantable member. The analyte may in particular be glucose. The medical device may also be used for drug administration.

Abstract: A pump system having a pump module (10) comprising a stator housing (28) with a chamber (30), a rotor (32) rotatably and axially slidably received in the chamber and comprising a first axial extension (46) with a liquid supply channel (50) and a second axial extension with a liquid supply channel (52), the first and second axial extensions having different diameters, and first and second sealing rings (54, 56), mounted around the first and second axial extensions.

Abstract: A pump including a stator, a rotor comprising an axial extension slidably and rotatably mounted at least partially in a rotor chamber of the stator, and at least first and second valves between an inlet and the rotor chamber, respectively between the rotor chamber and an outlet, that open and close as, a function of at least the angular displacement of the rotor. The pump comprises interacting cam elements on the rotor and stator and biasing means acting on the rotor for applying a force on the rotor in the axial direction of the stator cam element.