Patents Assigned to Sensors for Medicine & Science, Inc.
-
Publication number: 20090264718Abstract: A quantitative measurement system includes an external unit and an internal unit are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit contains optoelectronics circuitry, a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry obtains quantitative measurement information and modifies a load as a function of the obtained information. The load in turn varies the amount of current through coil, which is coupled to a coil of the external unit. A demodulator detects the current variations induced in the external coil by the internal coil coupled thereto, and applies the detected signal to processing circuitry, such as a pulse counter and computer interface, for processing the signal into computer-readable format for inputting to a computer.Type: ApplicationFiled: June 29, 2009Publication date: October 22, 2009Applicant: Sensors for Medicine and Science,Inc.Inventor: Jeffery C. LESHO
-
Patent number: 7553280Abstract: A quantitative measurement system includes an external unit (101a) and an internal unit (102a) are provided for obtaining quantitative analyte measurements, such as within the body. In one example of an application of the system, the internal unit (102a) would be implanted either subcutaneously or otherwise within the body of a subject. The internal unit (102a) contains optoelectronics circuitry (102b), a component of which may be comprised of a fluorescence sensing device. The optoelectronics circuitry (102b) obtains quantitative measurement information and modifies a load (102c) as a function of the obtained information. The load (102c) in turn varies the amount of current through coil (102d), which is coupled to a coil (101f) of the external unit (101a).Type: GrantFiled: June 27, 2001Date of Patent: June 30, 2009Assignee: Sensors for Medicine and Science, Inc.Inventor: Jeffery C. Lesho
-
Publication number: 20090146078Abstract: The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.Type: ApplicationFiled: May 19, 2008Publication date: June 11, 2009Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Earl Colvin, JR., Jeffery C. Lesho, Carrie R. Lorenz
-
Publication number: 20090039286Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: ApplicationFiled: July 28, 2008Publication date: February 12, 2009Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Earl COLVIN,, JR., Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert William Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
-
Publication number: 20080218759Abstract: A light emitting diode for harsh environments includes a substantially transparent substrate, a semiconductor layer deposited on a bottom surface of the substrate, several bonding pads, coupled to the semiconductor layer, formed on the bottom surface of the substrate, and a micro post, formed on each bonding pad, for electrically connecting the light emitting diode to a printed circuit board. An underfill layer may be provided between the bottom surface of the substrate and the top surface of the printed circuit board, to reduce water infiltration under the light emitting diode substrate. Additionally, a diffuser may be mounted to a top surface of the light emitting diode substrate to diffuse the light emitted through the top surface.Type: ApplicationFiled: March 6, 2008Publication date: September 11, 2008Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC.Inventors: Jason D. Colvin, Arthur E. Colvin, Andrew DeHennis, Jody L. Krsmanovic
-
Patent number: 7405387Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: GrantFiled: December 28, 2006Date of Patent: July 29, 2008Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert William Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
-
Publication number: 20080145944Abstract: Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.Type: ApplicationFiled: November 30, 2007Publication date: June 19, 2008Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Mark Alan Mortellaro, Aneta Modzelewska
-
Publication number: 20080139904Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: ApplicationFiled: December 10, 2007Publication date: June 12, 2008Applicant: SENSORS FOR MEDICINE AND SCIENCE, INC.Inventors: Arthur E. Colvin, Casey J. O'Connor, Andrew D. DeHennis
-
Patent number: 7375347Abstract: The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.Type: GrantFiled: April 26, 2004Date of Patent: May 20, 2008Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur Earl Colvin, Jr., Jeffery C. Lesho, Carrie R. Lorenz
-
Patent number: 7308292Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: GrantFiled: April 15, 2005Date of Patent: December 11, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Casey J. O'Connor, Andrew D. DeHennis
-
Patent number: 7289836Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.Type: GrantFiled: January 27, 2006Date of Patent: October 30, 2007Assignee: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin, Jr.
-
Patent number: 7227156Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: GrantFiled: October 21, 2005Date of Patent: June 5, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert William Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
-
Publication number: 20070102649Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: ApplicationFiled: December 28, 2006Publication date: May 10, 2007Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Paul Zerwekh, Jeffrey Lesho, Robert Lynn, Carrie Lorenz, Casey O'Connor, Steven Walters
-
Publication number: 20070059210Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions.Type: ApplicationFiled: November 13, 2006Publication date: March 15, 2007Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Robert Lynn
-
Patent number: 7190445Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.Type: GrantFiled: June 24, 2005Date of Patent: March 13, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Steven J. Walters
-
Patent number: 7157723Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: GrantFiled: April 14, 2004Date of Patent: January 2, 2007Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur Earl Colvin, Paul Samuel Zerwekh, Jeffrey C. Lesho, Robert William Lynn, Carrie R. Lorenz, Casey J. O'Connor, Steven J. Walters
-
Publication number: 20060281185Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: ApplicationFiled: June 8, 2006Publication date: December 14, 2006Applicant: Sensors for Medicine and Science, Inc.Inventor: Arthur Colvin
-
Publication number: 20060282042Abstract: The present invention provides an insertion device and method for implanting a biosensor into a patient subject. In one embodiment, a biosensor is stored in the instrument's hydration chamber which enables the biosensor to maintain proper hydration and sterilization prior to insertion. The instrument further includes a plunger that travels along a channel within the support device. After the biosensor is placed into the channel, the user pushes the plunger causing the biosensor to move through the channel and a hollow tube and into the patient subject. The present invention also provides for packaging and storing a biosensor and insertion device so that the biosensor is hydrated and sterile prior to insertion.Type: ApplicationFiled: June 7, 2006Publication date: December 14, 2006Applicant: Sensors for Medicine and Science, Inc.Inventors: Steven Walters, Casey O'Connor
-
Patent number: 7135342Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions.Type: GrantFiled: May 3, 2002Date of Patent: November 14, 2006Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Robert W. Lynn
-
Publication number: 20060231749Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: ApplicationFiled: April 15, 2005Publication date: October 19, 2006Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Casey O'Connor, Andrew DeHennis