Patents Assigned to Sensors for Medicine & Science
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Publication number: 20060282042Abstract: The present invention provides an insertion device and method for implanting a biosensor into a patient subject. In one embodiment, a biosensor is stored in the instrument's hydration chamber which enables the biosensor to maintain proper hydration and sterilization prior to insertion. The instrument further includes a plunger that travels along a channel within the support device. After the biosensor is placed into the channel, the user pushes the plunger causing the biosensor to move through the channel and a hollow tube and into the patient subject. The present invention also provides for packaging and storing a biosensor and insertion device so that the biosensor is hydrated and sterile prior to insertion.Type: ApplicationFiled: June 7, 2006Publication date: December 14, 2006Applicant: Sensors for Medicine and Science, Inc.Inventors: Steven Walters, Casey O'Connor
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Patent number: 7135342Abstract: An electro-optical sensing device for detecting the presence and concentration of an analyte in a liquid or gaseous medium includes a pair of indicator elements positioned to receive radiation from a radiation source and transmit radiation to a pair of photosensitive elements. The indicator elements each contain indicator molecules having an optical characteristic responsive to the presence of an analyte; however, one of the indicator elements is covered by an analyte-impermeable chamber that renders the indicator element insensitive to the presence of the analyte in the medium outside the chamber so that it can be used as a reference to cancel environmental and systemic variables that affect both indicator elements. The chamber preferably holds an analyte-containing fluid in contact with the reference indicator element so that the indicator elements operate under nominally identical conditions.Type: GrantFiled: May 3, 2002Date of Patent: November 14, 2006Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Robert W. Lynn
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Publication number: 20060231749Abstract: The present invention provides an electro-optical sensing device for detecting the presence or concentration of an analyte. More particularly, the invention relates to (but is not in all cases necessarily limited to) optical-based sensing devices which are characterized by being totally self-contained, with a smooth and rounded oblong, oval, or elliptical shape (e.g., a bean- or pharmaceutical capsule-shape) and a size which permits the device to be implanted in humans for in-situ detection of various analytes.Type: ApplicationFiled: April 15, 2005Publication date: October 19, 2006Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Casey O'Connor, Andrew DeHennis
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Patent number: 7078554Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: GrantFiled: October 4, 2004Date of Patent: July 18, 2006Assignee: Sensors for Medicine and Science, Inc.Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik
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Publication number: 20060149143Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.Type: ApplicationFiled: January 27, 2006Publication date: July 6, 2006Applicant: Sensors for Medicine and ScienceInventor: Arthur Colvin
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Patent number: 7060503Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: GrantFiled: March 1, 2004Date of Patent: June 13, 2006Assignee: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin, Jr.
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Publication number: 20060092421Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: ApplicationFiled: October 21, 2005Publication date: May 4, 2006Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Paul Zerwekh, Jeffrey Lesho, Robert Lynn, Carrie Lorenz, Casey O'Connor, Steven Walters
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Patent number: 7016714Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.Type: GrantFiled: February 24, 2004Date of Patent: March 21, 2006Assignee: Sensors for Medicine and ScienceInventor: Arthur E. Colvin, Jr.
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Publication number: 20060047327Abstract: The present invention provides, among other things, a sensor system, having (1) a sensor implanted in a body part of the subject, wherein the sensor has a first antenna, and (2) a sensor reader worn on the subject's body part, wherein the sensor reader has a band housing a second antenna, which is inductively coupled with the first antenna, for enabling the sensor reader to communicate with the sensor.Type: ApplicationFiled: August 24, 2004Publication date: March 2, 2006Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Benjamin McLeod, Casey O'Connor, Burleigh Hutchins, Colleen Shannon
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Publication number: 20050237518Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.Type: ApplicationFiled: June 24, 2005Publication date: October 27, 2005Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Steven Walters
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Publication number: 20050236580Abstract: The present invention provides a method for increasing the lifetime of an optical sensor. In one aspect, the method includes the step of configuring the optical sensor so that the duty cycle of sensor's radiant source is less than 100% over a continuous period amount of time when the sensor is periodically obtaining data regarding an analyte. By operating the sensor according to the above inventive method, the indicator molecules of the optical sensor are not excited during the entire continuous period of time during which the sensor is needed to provide data regarding the presence or concentration of a substance. Thus, the method increases the life of the indicator molecules.Type: ApplicationFiled: April 26, 2004Publication date: October 27, 2005Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Jeffery Lesho, Carrie Lorenz
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Publication number: 20050234316Abstract: The present invention provides a biocompatible circuit assembly that includes a circuit encased within a housing. In some embodiments, the housing is a PMMA housing and before the circuit is enclosed within the housing the circuit is encased within a brick of epoxy.Type: ApplicationFiled: April 16, 2004Publication date: October 20, 2005Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Carrie Lorenz, Casey O'Connor, Steven Walters
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Publication number: 20050227242Abstract: The invention relates to immobilization methods, in particular for immobilizing indicator molecules on supports such as sensors and to sensors having those molecules immobilized to their surface. Non-covalent immobilization of macromolecular indicator molecules on those supports via mechanical interlacing with polymers at the surface of a support and via ionic bonding via charged moieties of indicator molecules and ionic groups on the surface of the support are disclosed.Type: ApplicationFiled: April 13, 2004Publication date: October 13, 2005Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Carrie Lorenz
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Patent number: 6940590Abstract: An optical sensor device for determining the presence or concentration of an analyte, contains a waveguide disposed over a light source and a light detector mounted on a surface of a substrate and separated by an internal baffle, wherein the waveguide has a thickness corresponding to a far field emission point of the light source as determined by a light shielding baffle between the light source and light detector. An analyte indicator matrix is disposed on the outer surface of the waveguide. The sensor device geometry takes advantage of only direct illumination of the indicator matrix, and direct collection of indicator matrix illumination, without any significant reflection by said waveguide. Undesirable light noise generated by the light source passes directly out of the device through the waveguide.Type: GrantFiled: December 11, 2002Date of Patent: September 6, 2005Assignee: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, Jr., Steven J. Walters
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Publication number: 20050035304Abstract: The present invention provides systems and methods for attenuating the effect of ambient light on optical sensors and for measuring and compensating quantitatively for the ambient light.Type: ApplicationFiled: April 14, 2004Publication date: February 17, 2005Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur Colvin, Paul Zerwekh, Jeffrey Lesho, Robert Lynn, Carrie Lorenz, Casey O'Connor, Steven Walters
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Publication number: 20040229370Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: ApplicationFiled: March 1, 2004Publication date: November 18, 2004Applicant: Sensors for Medicine and Science, Inc.Inventor: Arthur E. Colvin
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Publication number: 20040206916Abstract: A printed circuit device used in conjunction with inductive power and data transmission applications is formed substantially of ferrite material, with an inductive coil conductor formed around the substrate to increase the electromagnetic properties of the coil for both power and data transmission functions, thereby eliminating the need for a discrete ferrite core wire-wound coil to be connected to the circuit device.Type: ApplicationFiled: April 15, 2004Publication date: October 21, 2004Applicant: Sensors for Medicine and Science, Inc.Inventors: Arthur E. Colvin, John S. Gerig, Paul Samel Zerwekh, Jeffery C. Lesho, Benjamin N. McLeod
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Patent number: 6800451Abstract: Compositions and methods for determining the presence or concentration of glucose in a sample which may also contain an alpha-hydroxy acid or a beta-diketone. The method uses a compound having at least two recognition elements for glucose, oriented such that the interaction between the compound and glucose is more stable than the interaction between the compound and the alpha-hydroxy acid or beta-diketone, such that the presence of the alpha-hydroxy acid or the beta-diketone does not substantially interfere with said determination.Type: GrantFiled: July 3, 2002Date of Patent: October 5, 2004Assignee: Sensors for Medicine and Science, Inc.Inventors: George Y. Daniloff, Aristotle G. Kalivretenos, Alexandre V. Nikolaitchik
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Patent number: 6794195Abstract: The invention relates to indicator molecules for detecting the presence or concentration of an analyte in a medium, such as a liquid, and to methods for achieving such detection. More particularly, the invention relates to copolymer macromolecules containing relatively hydrophobic indicator component monomers, and hydrophilic monomers, such that the macromolecule is capable of use in an aqueous environment.Type: GrantFiled: August 3, 2001Date of Patent: September 21, 2004Assignee: Sensors for Medicine & Science, Inc.Inventor: Arthur E. Colvin, Jr.
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Publication number: 20040176669Abstract: An optical-based sensor for detecting the presence or amount of an analyte using both indicator and reference channels. The sensor has a sensor body with a source of radiation embedded therein. Radiation emitted by the source interacts with indicator membrane indicator molecules proximate the surface of the body. At least one optical characteristic of these indicator molecules varies with analyte concentration. For example, the level of fluorescence of fluorescent indicator molecules or the amount of light absorbed by light-absorbing indicator molecules can vary as a function of analyte concentration. In addition, radiation emitted by the source also interacts with reference membrane indicator molecules proximate the surface of the body. Radiation (e.g., light) emitted or reflected by these indicator molecules enters and is internally reflected in the sensor body.Type: ApplicationFiled: February 24, 2004Publication date: September 9, 2004Applicant: Sensors for Medicine and ScienceInventor: Arthur E. Colvin