Abstract: The invention relates to a method for digitally collecting a sample by a microscope. In order to obtain a rapid analysis of the sample by a physician, it is advantageous if the sample has been already collected in regions which have not yet been viewed by the physician. This can be achieved when a viewing section of the sample is selected, a microscope lens is moved in a scanning mode over this viewing section first in a sequence of offset images covering the viewing section. The image is digitally recorded and the represented, and subsequently the scanning route is continued with a sequence of images outside of the selected viewing section.

Abstract: The invention relates to a microscopy method for identifying target objects (32) having a predetermined optical property in material (6) to be analyzed.

Abstract: The invention relates to a microscopy method for identifying target objects (32) having a predetermined optical property in material (6) to be analyzed.

Abstract: An autofocus apparatus and a method achieve a higher level of speed and robustness, and are particularly suited for fluorescence microscopy of biological samples, automated microscopy and scanning microscopy. A high speed is achieved via a light pattern in the sample, detected spatially resolved by a detector generating at least two signals corresponding to a reflex pattern of the light pattern. The two signals are subtracted generating a positioning signal and the focus of the objective in the sample is adjusted depending on the positioning signal.

Abstract: The invention relates to an apparatus and processes for optical measurement and detection with real-time closed-loop controls, which enable higher levels of performance. The invention is especially suitable for applications such as spectroscopy; microscopy; biochemical assays; processes and reactions on miniaturized formats (such as those involving micro-/nano-plates, micro-formats & micro-arrays, chemistry-on-chip, lab-on-chip, micro-channels and micro-fluidics, where dimensions are on micron scale and volumes are in the sub-nanoliter range). Such “intelligent sensing” allows higher data quality and reliability, higher measurement and analysis throughput and lower cost. The invention uses fast real-time adaptive digital signal processing and controls directly at the point where data is sensed.

Abstract: An autofocus apparatus and a method achieve a higher level of speed and robustness, and are particularly suited for fluorescence microscopy of biological samples, automated microscopy and scanning microscopy. A high speed is achieved via a light pattern in the sample, detected spatially resolved by a detector generating at least two signals corresponding to a reflex pattern of the light pattern. The two signals are subtracted generating a positioning signal and the focus of the objective in the sample is adjusted depending on the positioning signal.

Abstract: The invention is based on a microscope, in particular a fluorescence analysis microscope, comprising an illumination carrier and illumination units arranged thereon for a reflected-light illumination of a sample region. In order to be able to illuminate a sample region uniformly in a simple manner by means of a compact device, it is proposed that at least three illumination units for the simultaneous reflected-light illumination of the sample region from different directions are arranged on the illumination carrier.

Abstract: The invention relates to an apparatus and processes for optical measurement and detection with real-time closed-loop controls, which enable higher levels of performance. The invention is especially suitable for applications such as spectroscopy; microscopy; biochemical assays; processes and reactions on miniaturized formats (such as those involving micro-/nano-plates, micro-formats & micro-arrays, chemistry-on-chip, lab-on-chip, micro-channels and micro-fluidics, where dimensions are on micron scale and columns are in the sub-nanoliter range). Such “intelligent sensing” allows higher data quality and reliability, higher measurement and analysis throughput and lower cost. The invention uses fast real-time adaptive digital signal processing and controls directly at the point where data is sensed.

Abstract: An apparatus and a method for photo-electric measurement is included; the apparatus comprises photo-electric conversion devices and an optical system which is modularly expandable in order to acquire electromagnetic radiation from a line or area of any desired size on an object. The optical system preferably separates the electromagnetic radiation modularly into a plurality of smaller segments and projects electromagnetic radiation corresponding to the smaller segments onto individual photo-electric conversion devices and sensor electronics related to said photo-electric conversion device(s). This enables the operating mode and functionality of said photo-electric conversion device(s) to be defined and changed in real-time, whereby functions such as the readout sequence of pixels and unlimited flexibility of pixel binning in two dimensions are fully programmable, and the photo-electric conversion device(s) can operate and/or be controlled independently and/or simultaneously.