Abstract: Systems and methods for treating a patient. The methods comprise: producing, by a radiotherapy system, a fused model for a superficial portion of the patient's skin by combining structural imaging data acquired using high frequency ultrasound and functional imaging data acquired using optical imaging; generating a treatment plan for the patient based on the fused model; storing the treatment plan; detecting, by a processor, an arrival of the patient at a medical facility using first information acquired from a first mobile device coupled to the patient; obtaining the treatment plan using the first information; and causing a state of medical equipment to be transitioned from a first configurable operational state in which a radiotherapy treatment head has a first position to a second configurable operational state in which the radiotherapy treatment head has a second different position, in accordance with the treatment plan.

Abstract: Real-time X-ray dosimetry sensing in intraoperative radiation therapy (IORT). According to one aspect, a treatment head comprises at least one X-ray component configured to facilitate generation of therapeutic radiation in the X-ray wavelength range. A resilient balloon is disposed over the treatment head and configured for receiving therein a fluid to facilitate X-ray treatment of a tumor cavity. A plurality of X-ray sensing elements is disposed at a plurality of locations distributed on the interior or exterior of the resilient balloon and configured for sensing X-ray radiation emanating from the treatment head. A control system is provided that is responsive to data received from the X-ray sensing elements to determine a magnitude of X-ray radiation detected at each of the X-ray sensing elements.

Abstract: Systems, method and devices for detecting, analyzing and treating lesions, such as skin cancer are disclosed. Such a system can include a high-frequency ultrasound imaging device to image a lesion. The system can also include a processor that executes instructions stored in memory to perform operations, and the operations can include receiving a plurality of images of the lesion from the high-frequency ultrasound imaging device, rendering a three dimensional model of the lesion using the plurality of images from the high-frequency ultrasound imaging device and determining a treatment dosimetry based on the three dimensional model of the lesion. The system can also include a radiotherapy device to provide radiotherapy treatment to the lesion, where the radiotherapy treatment is based on the treatment dosimetry.

Abstract: Systems and methods for radiation therapy. The methods comprise: acquiring an image of a treatment area using a Robotic Sculpted Beam Radiation Treatment System (“RCBRTS”); presenting, by a Mobile Computing Platform (“MCP”), the image in a GUI; creating a Real-Time Beam Sculpting Treatment Plan (“RTBSTP”) for the patient based on user inputs to MCP via GUI; verifying an expected effectiveness of RTBSTP using a virtual measurement component of GUI (where the virtual measurement component simultaneously provides distance measurements and radiation dose deposition measurements associated with the patient's anatomy and RTBSTP); verifying the final treatment plan using cross sectional 3D view and/or AR view; programming RCBRTS such that radiation therapy delivery will be provided in accordance with RTBSTP; setting RCBRTS so part of it will be inserted into a cavity formed during a medical procedure; and/or performing operations by RCBRTS to apply radiation to the patient.

Abstract: Intraoperative radiation therapy involves a treatment head disposed on a distal end of a robotic arm. An X-ray component included as part of the treatment head generates therapeutic radiation in the X-ray wavelength range. At least one patient motion sensor detects a breathing movement of a patient body. A control system dynamically controls a position of the treatment head by causing a position variation in at least one of the movable joints comprising the robotic arm. This movement is managed so that a relative motion as between the treatment head and a tumor bed internal of the patient is minimized.

Abstract: Three dimensional beam forming X-ray source includes an electron beam generator (EBG) to generate an electron beam. A target element is disposed a predetermined distance from the EBG and positioned to intercept the electron beam. The target element is responsive to the electron beam to generate X-ray radiation. A beam former is disposed proximate to the target element and comprised of a material which interacts with the X-ray radiation to form an X-ray beam. An EBG control system controls at least one of a beam pattern and a direction of the X-ray beam by selectively varying a location where the electron beam intersects the target element to control an interaction of the X-ray radiation with the beam-former.

Abstract: A radiotherapy system including a radiotherapy component, a structural imaging component, a functional imaging component, and a workstation coupled to the radiotherapy component, the structural imaging component, and the functional imaging component. The workstation includes a processor which combines the structural imaging data and the functional imaging data to produce a fused model for a least a portion of the region of interest, to generate a plan for radiotherapy treatment of the region of interest based on the fused model, and apply, via the radiotherapy component, the radiotherapy treatment.

Abstract: X-ray delivery system includes a portable base unit to which a first end of a robotic arm is mounted. An X-ray treatment head is disposed on a second end of the robotic arm. The X-ray treatment head includes an X-ray component configured to generate therapeutic radiation in the X-ray wavelength range. A calibration well is disposed at a predetermined location in the portable base unit. The calibration well is comprised of a recess into which the X-ray treatment head can be received and having at least one port through which the X ray treatment head can be inserted by the robotic arm for calibration operations. The calibration well includes a plurality of X-ray radiation sensing elements disposed at distributed locations around a periphery of the calibration well.