Abstract: A hiatal hernia reduction device and method includes positioning a device having a wall that is generally configured to the normal anatomy at the gastro-esophageal region of a person without a hiatal hernia. The anatomy of the patient at the gastro-esophageal region is formed substantially to the anatomy of the normal person without a hiatal hernia.

Abstract: A stress reduction device and method includes positioning a device at the gastro-esophageal region of the patient. The device has a wall that is generally configured to the anatomy at the gastro-esophageal region of the patient. A strain is applied with the wall at the gastro-esophageal region, thereby increasing generation of at least one neuro-humoral transmitter.

Abstract: A gastroesophageal reflux disease (GERD) reduction device and method includes providing a wall that is generally configured to the anatomy at the gastroesophageal region of a normal person without reflux The device is positioned at the gastroesophageal region of the patient The anatomy of the patient at the gastro-esophageal region is formed to the anatomy of the person without reflux Additional applications include reduction of a hiatal hernia and reduction of stress through increasing the generation of at least one neuro-humoral transmitter.

Abstract: An implantable medical device and method of implanting a medical device in a hollow organ or cavity lined with the mucosa includes providing a medical device having a wall configured to the size and shape of a portion of a cavity or hollow organ lined with the mucosa. At least one opening is provided in the wall that is large enough to receive a section of the mucosa extending in the opening. The wall is positioned against the portion of the cavity or hollow organ thereby receiving the section of the mucosa within the opening. A retainer may be provided to retain the section of the mucosa within the opening while maintaining perfusion of the section of the mucosa.

Abstract: A natural orifice luminal device and method of performing a natural orifice luminal procedure includes providing a generally closed body. The generally closed body has a size and shape to be retained by a portion of the lumen defining an aperture between the lumen and a space adjacent to the lumen. The generally closed body is adapted to substantially seal the aperture from passage of gas between the lumen and the space adjacent to the lumen. In this manner, the lumen and the space adjacent to the lumen can be at different gas pressures.

Abstract: A gastro-intestinal therapeutic device and method includes providing a therapeutic device having a body and an anchoring mechanism. The anchoring mechanism is adapted to resist distal migration of said body in a gastro-intestinal tract. The body is generally configured to a portion of the gastro-intestinal tract and has a first wall portion and a second wall portion. The first wall portion defines a generally sealed membrane. The second wall portion has a scar-forming agent.

Abstract: A medical agent delivery system and method of dispensing a medical agent include providing a medical agent dispensing member and supporting said medical agent dispensing member at the gastro-esophageal region of the patient.