Abstract: The present disclosure provides a pharmaceutical composition comprising a NUPR1 isoform A inhibitor as an active ingredient. Pharmaceutical compositions comprising an NUPR1 isoform A inhibitor may be used in methods of preventing or treating cancer, in methods of diagnosing or predicting prognosis of cancer comprising an agent for measuring an expression or activity level of a NUPR1 isoform A, in a kit for diagnosing or predicting prognosis of cancer comprising the composition, methods for screening a substance for inhibiting cancer cell proliferation or metastasis, methods for providing information for cancer cell proliferation or metastasis, in food compositions for preventing or improving cancer comprising a NUPR1 isoform A inhibitor as an active ingredient, and in feed compositions for preventing or improving cancer comprising a NUPR1 isoform A inhibitor as an active ingredient.

Abstract: Disclosed is a knee joint guide apparatus which can be driven even at any point on a plane in which an instantaneous rotation center of a knee joint can be positioned by a self-alignment function, and can also implement output performance required for a walking operation through a mechanical advantage change depending on a flexion angle. The knee joint guide apparatus includes: a proximal body link provided above a knee joint; a distal body link provided at a location corresponding to the proximal body link below the knee joint; and a planar rigid body 6-bar linkage mechanism including a plurality of revolute joints and a plurality of prismatic joints, and a plurality of links between the proximal body link and the distal body link to output a mechanical advantage depending on a flexion angle of the knee joint in movement of the knee joint with a self-alignment function.

Abstract: Proposed are an apparatus for and a method of controlling a vehicle suspension. The apparatus includes a sensor configured to acquire at least one of information on a road surface in front of a vehicle and state information of the vehicle; and a processor configured to predict a vehicular behavior based on the information acquired through the sensor and actuator information and to control at least one of a ride height of the vehicle, stiffness of an air spring, and a damping force of a damper based on the predicted vehicular behavior.

Abstract: One aspect of the disclosure relates to a cargo delivery system comprising an autophagy targeting ligand and a target-binding ligand. In one aspect of the disclosure, by comprising an autophagy targeting ligand, cargo, which is a target-binding ligand that specifically binds to a target, is delivered to the p62 protein and autophagy is activated, so that depending on the type of target-binding ligand used, a target to be degraded can be selectively and directly removed. Accordingly, the cargo delivery system according to an aspect of the disclosure may be used in pharmaceutical compositions or food compositions for preventing, alimerating, and treating various diseases.

Abstract: A memory module includes a substrate, an allocator, memory cluster packages and serial communication lanes. The allocator is mounted on the substrate, and communicates with an external device through a CXL interface. The memory cluster packages are mounted on the substrate, and are controlled by the allocator. Each of the memory cluster packages includes memories and a memory controller. The serial communication lanes are disposed on the substrate for communications between the allocator and the memory cluster packages. A first memory cluster package communicates with the allocator through a first serial communication lane and the serial interface. A second memory cluster package communicates with the first memory cluster package through a second serial communication lane and the serial interface.

Abstract: An LED device includes a light emission layer including a first semiconductor layer including a first surface and a second surface facing the first surface, the second surface having an area larger than an area of the first surface, an active layer on the first surface, and a second semiconductor layer on the active layer, an insulating layer on the first surface, the insulating layer defining an open region of the first semiconductor layer, a first electrode that contacts the first semiconductor layer via the open region, and a second electrode on the second semiconductor layer and contacting the second semiconductor layer.

Abstract: The present invention relates to a micro LED driving circuit comprising a double gate transistor, and comprises: a PWM circuit unit for adjusting the light emission time of a micro LED; and a CCG circuit unit for controlling, on the basis of PWM data voltage, that a certain current is supplied during light emission of the micro LED.

Abstract: The present invention relates to a pharmaceutical composition for preventing or treating colorectal cancer comprising estrogen and an anti-PD-L1 antibody, and a composition comprising estrogen for promoting anti-cancer effects of an anti-PD-L1 antibody. Particularly, a combination therapy of estrogen and an anti-PD-L1 antibody carried out in a colorectal cancer model exhibits synergistic effects in tumor growth inhibition that are greater than those of when each is used alone, and induces changes in tumor-related cell populations, and thus is effective as a treatment in precision medicine.

Abstract: Provided are a method of analyzing biological samples, an analytical chip and an analytical system comprising same, the method comprising the steps of: introducing structures for assisting the formation of bioreactors on a substrate; providing a plurality of bioreactors on the substrate by means of forming the bioreactors, which are holding biological samples, on the peripheral parts of the respective structures so as to come in contact with the structures in at least one region; and checking a change in the biological samples present in the bioreactors.

Abstract: Disclosed is a blood-brain barrier vascular network implemented in a microfluidic chip. The blood-brain bather vascular network structure (BBB on a chip) (in vitro blood-brain bather (BBB)-on-a chip) formed in a microfluidic chip manufactured by a present manufacturing method of the in vitro blood-brain barrier (BBB)-on-a chip may reconstruct the blood-brain barrier in a real human body more similarly due to a specific cell configuration, compared to the conventional in vitro blood-brain barrier (BBB)-on-a chip, and thus may be used as a more accurate in vitro blood-brain barrier, and may be used for the development of various cellular therapeutic agents or drugs that work in the treatment of various brain diseases.

Abstract: The present disclosure may provide a metal-graphene composite having excellent mechanical properties.

Abstract: A quantum computing device according to an aspect of the present disclosure includes an ion trap chip including direct current (DC) electrodes and radio frequency (RF) rails to form a plurality of horizontal traps and one or morevertical traps, and a controller configured to trap ions by controlling the ion trap chip, adjust positions of the ions, and apply laser beam to the ions to perform gate operations. The controller performs traversal gate operations between qubits arranged in the horizontal trap area based on qubit connectivity of only qubits trapped in the same horizontal trap, moves the qubits arranged in the horizontal trap area to the vertical trap adjacent to the horizontal trap area through parallel shuttling, perform quantum error correction, and continues traversal gate operations after shuttling to an adjacent horizontal trap area through parallel shuttling.

Abstract: The present disclosure relates to an ultrasonic transmission apparatus and a wave control method, and more particularly, to an ultrasonic transmission apparatus and a wave control method which enable an ultrasonic wave to transmit through an obstacle.

Abstract: The present invention relates to a method of diagnosing ovarian cancer through microbial metagenomic analysis, and more particularly to a method of diagnosing ovarian cancer by analyzing an increase or decrease in content of specific bacteria or archaea-derived extracellular vesicles through metagenomic analysis using a subject-derived sample. Extracellular vesicles secreted from microorganisms existing in the environment are absorbed into the human body, and thus may directly affect the occurrence of cancer, and it is difficult to diagnose ovarian cancer early before symptoms thereof so that efficient treatment thereof is difficult.

Abstract: The disclosure relates to a device for detecting therapeutic radiation based on an optical disk with solar cells. The radiation detecting device may include at least one optical disk formed of a water-equivalent material, disposed perpendicular to a first direction in which the radiation is incident, and converting the radiation into visible light; a solar cell disposed on one side of the at least one optical disk, converting the visible light into an electrical signal; and a processing module for collecting and processing the electrical signal outputted from the solar cell.

Abstract: Disclosed is a fibre-based wearable patch antenna. The fibre-based wearable patch antenna comprises: a radiating patch; a substrate on which the radiating patch is attached; a ground surface which is located below the substrate and has a slot formed therein; and a cable for the supply of power to the radiating patch, wherein the invention is formed integrally with clothing and the cable can be attached below the ground surface.

Abstract: An Interferon Gamma Inducible Protein 16 (IFI16) mutant gene and its use as a marker for predicting, diagnosing, or prognosticating risk or severity of chronic liver disease is described. As a result of performing genomic analysis on NAFLD and NASH patient groups, it was confirmed that the frequency of IFI16 single-nucleotide variants (SNVs) including rs2276404, rs73021847, rs7532207, and rs6940 was increased, and the expression of the IFI16 mutant gene was increased depending on the disease stage of liver disease. The IFI16 SNV was highly expressed in infiltrating macrophages, playing a role in macrophage-induced inflammatory processes, and the IFI16 variant bound more strongly to dsDNA than wild-type IFI16, exacerbating the impaired mitochondrial DNA-sensing response signaling of the IFI16-PYCARD-CASP1 pathway. Thus, the IFI16 mutant gene may be used for predicting, diagnosing, or prognosticating risk or severity of chronic liver disease.

Abstract: Disclosed is a multi-DOF wearable assistance device, which is worn on a human body and assists movement, including: a plurality of blocks arranged to be spaced apart along the human body; a linear actuator disposed left and right in parallel between the neighboring blocks; and a joint connector providing a joint connection to freely change a connection angle between the block and opposite ends of the linear actuator.

Abstract: A non-fixed shoulder brace is provided comprising: an affected shoulder support which is supported on an affected shoulder of a wearer; a waist support coupled to the wearer's waist; an affected arm mounting part in which the wearer's affected arm is inserted and which is supported by means of an affected shoulder strap member from the affected shoulder support; and an affected upper limb exercise assistance apparatus coupled to both ends of the waist support and disposed between the wearer's waist and the affected arm mounting part.

Abstract: A memory controller includes a dirty group detector configured to, in response to receiving a request for writing data to a memory, modify addresses of a cache group related to a physical address of the memory, increase counters corresponding to the modified addresses of the cache group, and detect whether the cache group is in a dirty state based on the counters; and a dirty list manager configured to manage the cache group in the dirty state and a dirty list including dirty bits according to a result of the detecting; wherein the dirty bits indicate whether a cache set included in the cache group is in the dirty state.