Abstract: The present disclosure relates to negative pressure-based gripping system for gripping and retaining a target, preferably a moving target, such as a heart of a human or animal, in a fixed position, comprising: a catheter having a tubular body; a proximal end; and a remotely operable and flexible distal end section with a distal opening; a negative pressure generator, such as a vacuum pump, in connection with the tubular body; and a control unit configured to position the distal end of the catheter, wherein said control unit is further configured to control an operation of the negative pressure generator such that a negative pressure is generated in the tubular body to grip the target by the distal opening of the catheter upon positioning of the distal opening adjacent to the target. The disclosure further relates to method for gripping and retaining a target, preferably a moving target, such as a heart of a human or animal, in a fixed position in relation to the device.

Abstract: The present disclosure relates to a tissue cutting system for cutting tissue of a heart, such as tissue of a septum of a heart, comprising: an outer tubular member having a proximal portion and a distal portion, said distal portion comprising a tissue resection window; a resection element axially slidably arranged inside the outer tubular member configured to resect tissue extending through the tissue resection window; at least one pressure sensor; wherein the outer tubular member and resection element are arranged to establish: a first fluid flow channel suitable for transporting resected tissue away from an area adjacent to the resection element; at least one second fluid flow channel configured to assist the first fluid flow channel in transporting resected tissue. The present disclosure further relates to a method for resecting tissue using the disclosed tissue cutting system.

Abstract: The present disclosure relates to a tissue cutting system for cutting tissue of a heart, such as tissue of a septum of a heart, comprising: an outer tubular member having a proximal portion and a distal portion, said distal portion comprising a tissue resection window; a resection element axially slidably arranged inside the outer tubular member configured to resect tissue extending through the tissue resection window; at least one pressure sensor; wherein the outer tubular member and resection element are arranged to establish: a first fluid flow channel suitable for transporting resected tissue away from an area adjacent to the resection element; at least one second fluid flow channel configured to assist the first fluid flow channel in transporting resected tissue. The present disclosure further relates to a method for resecting tissue using the disclosed tissue cutting system.