Patents Assigned to Sequent Scientific Limited
  • Patent number: 8759513
    Abstract: The present invention discloses a stable amorphous form of Rifaximin characterized by having X-ray powder diffraction pattern as given in FIG. 1, having a 2? peaks at 7.2 and having moisture content in the range of 3% to 4% preferably, 3.4% to 3.7%. This invention also discloses a novel process for its preparation.
    Type: Grant
    Filed: August 24, 2011
    Date of Patent: June 24, 2014
    Assignee: Sequent Scientific Limited
    Inventors: Sumangala Venkatramana, Vijesh Alanthatta Madathil, Pejala Kakrannaya Vasudeva, Thangavel Arulmoli
  • Patent number: 8754215
    Abstract: The present disclosure describes a novel, cost-effective process for preparation of a 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino-[2,1-a]isoquinoline derivatives. Specifically, it discloses a process for the preparation of the anthelmintic drug praziquantel through the use of a novel intermediate, 2-[(2,2-dimethoxyethyl)benzyl amino]-N-phenethylacetamide. This present disclosure also describes a novel crystalline form of 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline.
    Type: Grant
    Filed: June 12, 2013
    Date of Patent: June 17, 2014
    Assignee: Sequent Scientific Limited
    Inventors: Lingappa Balaya, Mahalinga Manjathuru, Yogeesh Derambala, Pejakala Kakrannaya Vasudeva, Thangavel Arulmoli
  • Publication number: 20140100385
    Abstract: The present invention relates to a process for the preparation of succinylcholine chloride, a pharmaceutically active compound used as skeletal muscle relaxant which comprises condensing succinic anhydride with N,N-diemthylaminoethanol using a catalyst in presence of a solvent to form bis[2-(dimethylamino)ethyl]succinate; in situ purifying the bis[2-(dimethylamino)ethyl]succinate using a base; reacting pure bis[2-(dimethylamino)ethyl]succinate with methyl chloride gas using an alcohol; and purifying the obtained crude succinylcholine chloride using water and alcohol.
    Type: Application
    Filed: February 20, 2013
    Publication date: April 10, 2014
    Applicant: SEQUENT SCIENTIFIC LIMITED
    Inventors: Mahalinga MANJATHURU, Anil Narayan MAYEKAR, Pejakala Kakrannaya VASUDEVA, Thangavel ARULMOLI, Gautam Kumar DAS
  • Publication number: 20130303782
    Abstract: The present invention discloses a novel, cost-effective process for preparation of a benzimidazole carbamates compound. Specifically, it relates to the process for the preparation of anti-parasite bulk drug albendazole. The process comprises a) thiocyanating 2-nitroaniline of formula VI with ammonium thiocyanated in presence of a halogen to obtain 2-nitro-4-thiocyanoaniline of formula V; b)propylating 2-nitro-4-thiocyanoaniline of formula V with propylbromide in presence of n-propanol and a base in absence of a phase transfer catalyst to obtain 4-propylthio-2-nitroaniline of formula III; C) reducing the nitro group of 4-propylthio-2-nitroaniline prepared in step b) by reacting an aqueous alkali metal sulphide or an alkaline metal sulphide to obtain 4-propylthio-o-phenylenediamine of formula II; and d)condensing 4-propylthio-o-phenylenediamine of formula II with alkali or alkaline earth metal salt of methylcyano carbamate in presence of an acid to form Albendazole of formula I.
    Type: Application
    Filed: November 23, 2011
    Publication date: November 14, 2013
    Applicant: SEQUENT SCIENTIFIC LIMITED
    Inventors: Ramkrishna Appaji Rane, Sushil Naithani, Rajendra Devendra Natikar, Sudhakar Verma, Thangavel Arulmoli
  • Publication number: 20130303781
    Abstract: The present invention discloses a method for preparing Triclabendazole comprising condensing N-(4,5-dichloro-2-ni-trophenyl)acetamide with 2,3-dichlorophenol to obtain 4-chloro-5(2,3-dichlorophenoxy)-2-nitrophenyl acetamide and it to obtain 4-chloro-5(2,3-dichlorophenoxy)-2-nitroaniline; reducing 4-chloro-5(2,3-dichlorophenoxy)-2-nitroaniline in presence of Raney nickel to obtain 4-chloro-5-(2,3-dichlorophenoxy)benzene-1,2-diamine of; cyclising 4-chloro-5-(2,3-dichlorophenoxy)benzene-1,2-diamine in presence of carbondisulfide to obtain 6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazole-2-thiol; methylating 6-chloro-5-(2,3-dichlorophenoxy)-1H-benzimidazole-2-thiol using a methylating agent to obtain triclabendazole methanesulfonate salt; converting triclabendazole methanesulfonate salt to hydrochloride salt of Triclabendazole and hydrolysing it to obtain Triclabendazole.
    Type: Application
    Filed: November 23, 2011
    Publication date: November 14, 2013
    Applicant: SEQUENT SCIENTIFIC LIMITED
    Inventors: Ramkrishna Appaji Rane, Sudhakar Verma, Thangavel Arulmoli
  • Publication number: 20130280350
    Abstract: A topical herbal composition comprising aqueous extract of leaf of Datura species alongwith pharmaceutically acceptable vehicle useful for the eradication of Lice (and nits) in human and Ticks (eggs and larvae) in animals wherein the said herbal extract is detoxified with neem is disclosed herein.
    Type: Application
    Filed: June 8, 2010
    Publication date: October 24, 2013
    Applicant: Sequent Scientific Limited
    Inventors: Jayashree Rajan, Balakrishnan Rajan
  • Patent number: 8383166
    Abstract: Disclosed herein is stable topical herbal composition, useful for the treatment of specific skin conditions, such as, including, but not limited to, psoriasis, eczema, dermatitis, inflammation, pigmentation, extreme dry skin and other skin conditions requiring therapeutic intervention, wherein the said topical herbal composition comprises, oil extract of Wrightia tinctoria in combination with hydrophobic excipients and other functional excipients, such as emulsifying agent, preservatives, humectant and anti oxidant.
    Type: Grant
    Filed: December 3, 2008
    Date of Patent: February 26, 2013
    Assignee: Sequent Scientific Limited
    Inventors: Parijat Kanaujia, Rajan Balakrishnan, Jayashree Rajan, Shivaraj Basavaraj Katageri