Patents Assigned to Sequenta LLC
  • T-CELL RECEPTOR CLONOTYPES SHARED AMONG ANKYLOSING SPONDYLITIS PATIENTS
    Publication number: 20150252422
    Abstract: The invention includes a method for determining the disease status of an individual suffering from ankylosing spondylitis by monitoring the individual's T-cell repertoire for the presence and/or level of clonotypes encoding T-cell receptor chains with segments identical to and/or related to the peptide LCASSLEASGSSYNEQFFGPGTRLTV (SEQ ID NO: 1) or the peptide VYFCASSDSSGSTDTQYFGPGTRLTV (SEQ ID NO: 2). The invention also includes therapeutic antibodies specific for these peptides for ameliorating the effects of ankylosing spondylitis.
    Type: Application
    Filed: October 25, 2012
    Publication date: September 10, 2015
    Applicant: Sequenta LLC
    Inventors: Malek Faham, Victoria Carlton, Martin Moorhead, Jianbiao Zheng, Thomas Asbury