Patents Assigned to Sequoia Sciences, Inc.
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Patent number: 10137192Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: April 8, 2018Date of Patent: November 27, 2018Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 10058608Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: October 8, 2017Date of Patent: August 28, 2018Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 9878037Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: October 17, 2016Date of Patent: January 30, 2018Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 9562031Abstract: The present invention generally relates to phenethyldihydrobenzodioxolone compounds and compositions useful for reducing or inhibiting tumor growth. It also relates to methods of use and the preparation of phenethyldihydrobenzodioxolone compounds.Type: GrantFiled: September 12, 2015Date of Patent: February 7, 2017Assignee: Sequoia Sciences, Inc.Inventors: Russell B Williams, Gary Eldridge, Courtney M. Starks, Peter Robert Guzzo, Zhongping Huang
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Patent number: 9504743Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: April 15, 2016Date of Patent: November 29, 2016Assignee: Sequoia Sciences, IncInventors: Gary Eldridge, Steven M Martin
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Patent number: 9492522Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: September 1, 2015Date of Patent: November 15, 2016Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 9415101Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: February 12, 2016Date of Patent: August 16, 2016Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 9415097Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: July 15, 2015Date of Patent: August 16, 2016Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M. Martin
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Patent number: 9149522Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: March 20, 2015Date of Patent: October 6, 2015Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 9149521Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: March 17, 2015Date of Patent: October 6, 2015Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Patent number: 9017698Abstract: This invention describes novel adjuvant compositions and formulations with excellent stability at refrigerated and room temperatures and up to and about 37° C. that can be produced at remarkably low costs. This invention describes novel vaccine compositions and formulations to treat and prevent urinary tract infections caused by gram-negative bacteria including Escherichia coli and multi-drug resistant E. coli. This invention also describes methods of administration of said novel vaccine compositions and formulations and methods of treatment to prevent and treat urinary tract infections caused by gram-negative bacteria including E. coli and multi-drug resistant E. coli.Type: GrantFiled: September 23, 2014Date of Patent: April 28, 2015Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Steven M Martin
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Publication number: 20130274256Abstract: Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.Type: ApplicationFiled: October 11, 2012Publication date: October 17, 2013Applicant: SEQUOIA SCIENCES, INC.Inventor: Sequoia Sciences, Inc.
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Patent number: 8324264Abstract: Certain multi-cyclic compounds and compositions thereof are useful for reducing or inhibiting the growth of bacterial biofilms and for controlling bacterial biofilm infections. Such compounds and compositions are also useful in methods for reducing or inhibiting the growth of biofilms and for controlling bacterial biofilm infections involving biofilms.Type: GrantFiled: July 22, 2011Date of Patent: December 4, 2012Assignee: Sequoia Sciences, Inc.Inventors: Gary R. Eldridge, Ronald Neil Buckle, Michael Ellis, Zhongping Huang, John Edward Reilly
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Publication number: 20100041753Abstract: The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.Type: ApplicationFiled: October 8, 2009Publication date: February 18, 2010Applicant: SEQUOIA SCIENCE, INC.Inventor: Gary R. Eldridge
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Publication number: 20100004480Abstract: The present invention discloses compounds, compositions, and methods of using such compounds and compositions to inhibit, reduce, prevent, and remove biofilms. The invention further relates to methods of inhibiting biofilms on various substrates, such as medical devices.Type: ApplicationFiled: August 3, 2009Publication date: January 7, 2010Applicant: Sequoia Sciences, Inc.Inventors: Gary R. Eldridge, Jin-Feng Hu
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Patent number: 7612045Abstract: The present invention provides compounds and compositions useful for controlling bacterial biofilms as well as for controlling and/or preventing bacterial infections. The compounds of the invention are pentacyclic acid triterpenes. Methods for controlling biofilms and for controlling and/or preventing bacterial infections are also disclosed.Type: GrantFiled: September 14, 2005Date of Patent: November 3, 2009Assignee: Sequoia Sciences, Inc.Inventor: Gary R. Eldridge
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Patent number: 7604978Abstract: The present invention relates to compositions and methods for reducing or inhibiting biofilm comprising modulating expression of a cysB gene in a cell. The invention also provides methods for modulating the expression of a cysB, cysD, cysI, cysJ, cysK, and ybiK. The invention further provides methods for identifying gene(s) involved in biofilm formation and for identifying biofilm inhibitors.Type: GrantFiled: March 21, 2005Date of Patent: October 20, 2009Assignee: Sequoia Sciences, Inc.Inventor: Gary R. Eldridge
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Publication number: 20090192327Abstract: The present invention discloses compounds, compositions, and methods of using such compounds and compositions to inhibit, reduce, prevent, and remove biofilms. The invention further relates to methods of inhibiting biofilms on various substrates, such as medical devices.Type: ApplicationFiled: December 3, 2008Publication date: July 30, 2009Applicant: Sequoia Sciences, Inc.Inventors: Gary R. Eldridge, Jin-Feng Hu, John W. Costerton, Mark Pasmore
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Publication number: 20080280770Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.Type: ApplicationFiled: July 2, 2008Publication date: November 13, 2008Applicant: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Lu Zeng, Peader Cremin, Chris Lee, Helene C. Vervoort, Marilyn Ghanem
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Patent number: 7367933Abstract: A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log P of from about ?1 to about 5 and a molecular weight less than about 1000 Daltons; thereby to produce a chemical compound library from at least one species of plant.Type: GrantFiled: February 21, 2006Date of Patent: May 6, 2008Assignee: Sequoia Sciences, Inc.Inventors: Gary Eldridge, Lu Zeng, Peader Cremin, Chris Lee, Helene C. Vervoort, Marilyn Ghanem