Abstract: An implantable perfusion device (2) comprises a tubular transmission line (4) with an inlet end (6), an outlet end (8) and a flow restriction element (10) located therebetween, whereby an inlet section (12) of the transmission line is defined between the inlet end and the flow restriction element and whereby an outlet section (14) of the transmission line is defined between the flow restriction element and the outlet end. Moreover, the device comprises a perfusion chamber (16) containing a load of biologically active cells and is provided with a fluid entrance (18), a fluid exit (20) and a chamber volume (22) formed therebetween. The fluid entrance comprises at least one first microchannel platelet (24) and the fluid exit comprises at least one second microchannel platelet (26), each one of the microchannel platelets comprising at least one array of microchannels (28) defining a fluid passage between respective external and internal platelet faces, the microchannels having an opening of 0.2 to 10 ?m.

Abstract: A fluid interface device for delivering fluid to and/or withdrawing fluid from a patient, the device comprises a peripheral base element (2) and a fluid transmission element (4) sealingly connected to the base element and forming a central portion of the device. The fluid transmission element comprises a front platelet (6) with a primary face (8) and a secondary face (10) opposed thereto, the primary face being in contact with a patient's body fluid region (12) when the device is implanted in the patient, the fluid transmission element further comprising a counterplate (14) sealingly stacked against the secondary face of the front platelet and forming a buffer volume (16) therebetween. The front platelet comprises at least one array of microchannels (18) defining a fluid passage between the buffer volume and the primary face, the microchannels having an opening of 0.2 to 10 ?m. The counterplate has at least one fluid port (20; 20a, 20b) for fluid delivery to and/or fluid withdrawal from the buffer volume.

Abstract: An implantable perfusion device (2) comprises a tubular transmission line (4) with an inlet end (6), an outlet end (8) and a flow restriction element (10) located therebetween, whereby an inlet section (12) of the transmission line is defined between the inlet end and the flow restriction element and whereby an outlet section (14) of the transmission line is defined between the flow restriction element and the outlet end. Moreover, the device comprises a perfusion chamber (16) containing a load of biologically active cells and is provided with a fluid entrance (18), a fluid exit (20) and a chamber volume (22) formed therebetween. The fluid entrance comprises at least one first microchannel platelet (24) and the fluid exit comprises at least one second microchannel platelet (26), each one of the microchannel platelets comprising at least one array of microchannels (28) defining a fluid passage between respective external and internal platelet faces, the microchannels having an opening of 0.2 to 10 ?m.

Abstract: A fluid interface device for delivering fluid to and/or withdrawing fluid from a patient, the device comprises a peripheral base element (2) and a fluid transmission element (4) sealingly connected to the base element and forming a central portion of the device. The fluid transmission element comprises a front platelet (6) with a primary face (8) and a secondary face (10) opposed thereto, the primary face being in contact with a patient's body fluid region (12) when the device is implanted in the patient, the fluid transmission element further comprising a counterplate (14) sealingly stacked against the secondary face of the front platelet and forming a buffer volume (16) therebetween. The front platelet comprises at least one array of microchannels (18) defining a fluid passage between the buffer volume and the primary face, the microchannels having an opening of 0.2 to 10???. The counterplate has at least one fluid port (20; 20a, 20b) for fluid delivery to and/or fluid withdrawal from the buffer volume.