Patents Assigned to Serina Therapeutics, Inc.
  • Patent number: 8883211
    Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.
    Type: Grant
    Filed: July 10, 2009
    Date of Patent: November 11, 2014
    Assignee: Serina Therapeutics, Inc.
    Inventors: Michael David Bentley, J. Milton Harris, Michael Reif, Rainer Jordon, Kunsang Yoon
  • Publication number: 20140271527
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.
    Type: Application
    Filed: November 1, 2012
    Publication date: September 18, 2014
    Applicant: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
  • Publication number: 20140112880
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Application
    Filed: December 2, 2013
    Publication date: April 24, 2014
    Applicant: Serina Therapeutics, Inc.
    Inventors: Randall MOREADITH, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Welmer, Bekir Dizman, Tacey Viegas
  • Publication number: 20140066577
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: August 2, 2013
    Publication date: March 6, 2014
    Applicant: Serina Therapeutics, Inc.
    Inventors: Kunsang YOON, J. Milton HARRIS, Michael David BENTLEY, Zhihac FANG, Tacey VIEGAS
  • Publication number: 20140011964
    Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.
    Type: Application
    Filed: August 7, 2013
    Publication date: January 9, 2014
    Applicant: Serina Therapeutics, Inc.
    Inventors: J. Milton HARRIS, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese, Tacey Viegas, Anna Mero
  • Patent number: 8597633
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Grant
    Filed: February 22, 2013
    Date of Patent: December 3, 2013
    Assignee: Serina Therapeutics, inc.
    Inventors: Randall Moreadith, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas
  • Patent number: 8501899
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: January 23, 2012
    Date of Patent: August 6, 2013
    Assignee: Serina Therapeutics, Inc.
    Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley, Zhihao Fang, Tacey Viegas
  • Publication number: 20130177521
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Application
    Filed: February 22, 2013
    Publication date: July 11, 2013
    Applicant: Serina Therapeutics, Inc.
    Inventor: Serina Therapeutics, Inc.
  • Patent number: 8383093
    Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.
    Type: Grant
    Filed: June 15, 2012
    Date of Patent: February 26, 2013
    Assignee: Serina Therapeutics, Inc.
    Inventors: Randall Moreadith, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas
  • Publication number: 20120136123
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: February 6, 2012
    Publication date: May 31, 2012
    Applicant: Serina Therapeutics, Inc.
    Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon
  • Publication number: 20120123055
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: January 23, 2012
    Publication date: May 17, 2012
    Applicant: Serina Therapeutics, Inc.
    Inventors: Kunsang Yoon, Michael David Bentley, J. Milton Harris, Zhihao Fang, Tacey Viegas
  • Patent number: 8110651
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: January 12, 2009
    Date of Patent: February 7, 2012
    Assignee: Serina Therapeutics, Inc.
    Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley
  • Patent number: 8101706
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Grant
    Filed: May 25, 2010
    Date of Patent: January 24, 2012
    Assignee: Serina Therapeutics, Inc.
    Inventors: Kunsang Yoon, Michael David Bentley, J. Milton Harris, Zhihao Fang, Tacey Viegas
  • Patent number: 8088884
    Abstract: The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: January 3, 2012
    Assignee: Serina Therapeutics, Inc.
    Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang
  • Publication number: 20110123453
    Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other poly-oxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.
    Type: Application
    Filed: July 10, 2009
    Publication date: May 26, 2011
    Applicant: Serina Therapeutics, Inc.
    Inventors: Michael David Bentley, J. Milton Harris, Michael Reif, Rainer Jordon, Kunsang Yoon
  • Patent number: 7943141
    Abstract: The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: May 17, 2011
    Assignee: Serina Therapeutics, Inc.
    Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese
  • Publication number: 20110009594
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: January 12, 2009
    Publication date: January 13, 2011
    Applicant: SERINA THERAPEUTICS, INC.
    Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley
  • Publication number: 20100330023
    Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.
    Type: Application
    Filed: May 25, 2010
    Publication date: December 30, 2010
    Applicant: Serina Therapeutics, Inc.
    Inventors: Kunsang Yoon, Michael David Bentley, J. Milton Harris, Zhihao Fang, Tacey Viegas
  • Publication number: 20100249368
    Abstract: The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.
    Type: Application
    Filed: September 29, 2008
    Publication date: September 30, 2010
    Applicant: SERINA THERAPEUTICS, INC.
    Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang