Patents Assigned to Serina Therapeutics, Inc.
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Patent number: 8883211Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other polyoxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.Type: GrantFiled: July 10, 2009Date of Patent: November 11, 2014Assignee: Serina Therapeutics, Inc.Inventors: Michael David Bentley, J. Milton Harris, Michael Reif, Rainer Jordon, Kunsang Yoon
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Publication number: 20140271527Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a cleavable moiety.Type: ApplicationFiled: November 1, 2012Publication date: September 18, 2014Applicant: Serina Therapeutics, Inc.Inventors: Randall Moreadith, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas, Michael David Bentley
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Publication number: 20140112880Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.Type: ApplicationFiled: December 2, 2013Publication date: April 24, 2014Applicant: Serina Therapeutics, Inc.Inventors: Randall MOREADITH, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Welmer, Bekir Dizman, Tacey Viegas
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Publication number: 20140066577Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: ApplicationFiled: August 2, 2013Publication date: March 6, 2014Applicant: Serina Therapeutics, Inc.Inventors: Kunsang YOON, J. Milton HARRIS, Michael David BENTLEY, Zhihac FANG, Tacey VIEGAS
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Publication number: 20140011964Abstract: The present disclosure provides POZ derivatives having a range of active functional groups allowing conjugation of POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives. In one embodiment, the POZ derivative is a terminally activated monofunctional POZ derivative.Type: ApplicationFiled: August 7, 2013Publication date: January 9, 2014Applicant: Serina Therapeutics, Inc.Inventors: J. Milton HARRIS, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese, Tacey Viegas, Anna Mero
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Patent number: 8597633Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.Type: GrantFiled: February 22, 2013Date of Patent: December 3, 2013Assignee: Serina Therapeutics, inc.Inventors: Randall Moreadith, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas
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Patent number: 8501899Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: GrantFiled: January 23, 2012Date of Patent: August 6, 2013Assignee: Serina Therapeutics, Inc.Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley, Zhihao Fang, Tacey Viegas
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Publication number: 20130177521Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.Type: ApplicationFiled: February 22, 2013Publication date: July 11, 2013Applicant: Serina Therapeutics, Inc.Inventor: Serina Therapeutics, Inc.
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Patent number: 8383093Abstract: The present disclosure provides polymer conjugates comprising a polymer and an agent, the agent linked to the polymer via a linking group containing a hydrolyzable moiety.Type: GrantFiled: June 15, 2012Date of Patent: February 26, 2013Assignee: Serina Therapeutics, Inc.Inventors: Randall Moreadith, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Rebecca Weimer, Bekir Dizman, Tacey Viegas
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Publication number: 20120136123Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: ApplicationFiled: February 6, 2012Publication date: May 31, 2012Applicant: Serina Therapeutics, Inc.Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon
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Publication number: 20120123055Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: ApplicationFiled: January 23, 2012Publication date: May 17, 2012Applicant: Serina Therapeutics, Inc.Inventors: Kunsang Yoon, Michael David Bentley, J. Milton Harris, Zhihao Fang, Tacey Viegas
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Patent number: 8110651Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: GrantFiled: January 12, 2009Date of Patent: February 7, 2012Assignee: Serina Therapeutics, Inc.Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley
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Patent number: 8101706Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: GrantFiled: May 25, 2010Date of Patent: January 24, 2012Assignee: Serina Therapeutics, Inc.Inventors: Kunsang Yoon, Michael David Bentley, J. Milton Harris, Zhihao Fang, Tacey Viegas
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Patent number: 8088884Abstract: The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.Type: GrantFiled: September 29, 2008Date of Patent: January 3, 2012Assignee: Serina Therapeutics, Inc.Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang
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Publication number: 20110123453Abstract: The present disclosure provides novel functional polyoxazoline derivatives prepared by terminating polyoxazoline polymerization with inert chemical groups. In addition, the present disclosure demonstrates the synthesis of novel electrophilic initiators with protected functional groups capable of initiating oxazoline polymerization and capable of surviving the conditions of polymerization. These initiators are used to synthesize the above inert-terminal polyoxazoline derivatives as well as other poly-oxazolines with active terminal groups. Furthermore, the present disclosure provides for polyoxazoline-lipid conjugates and liposomal compositions prepared using such polyoxazoline-lipid conjugates. Methods of using the foregoing to prepare conjugates with target molecules are also disclosed.Type: ApplicationFiled: July 10, 2009Publication date: May 26, 2011Applicant: Serina Therapeutics, Inc.Inventors: Michael David Bentley, J. Milton Harris, Michael Reif, Rainer Jordon, Kunsang Yoon
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Patent number: 7943141Abstract: The present disclosure provides terminally activated monofunctional POZ derivatives having a range of functional active groups allowing conjugation of the monofunctional POZ derivatives to a variety of target molecules under a wide range of reaction conditions to produce a hydrolytically stable target molecule-POZ conjugate. Furthermore, the present disclosure provides novel methods of synthesis for the disclosed terminally activated monofunctional POZ derivatives and hydrolytically stable target molecule-POZ conjugates created using the disclosed terminally activated monofunctional POZ derivatives.Type: GrantFiled: February 28, 2008Date of Patent: May 17, 2011Assignee: Serina Therapeutics, Inc.Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang, Francesco Maria Veronese
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Publication number: 20110009594Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: ApplicationFiled: January 12, 2009Publication date: January 13, 2011Applicant: SERINA THERAPEUTICS, INC.Inventors: Kunsang Yoon, J. Milton Harris, Michael David Bentley
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Publication number: 20100330023Abstract: The present disclosure provides copolymers of 2-substituted-2-oxazolines possessing two or three reactive functional groups which are also chemically orthogonal. The copolymers described may be random copolymers, block copolymers or a mixture of random and block copolymer configurations. Furthermore, the present disclosure provides novel methods for synthesizing the above polymers and for conjugating to molecules such as targeting, diagnostic and therapeutic agents.Type: ApplicationFiled: May 25, 2010Publication date: December 30, 2010Applicant: Serina Therapeutics, Inc.Inventors: Kunsang Yoon, Michael David Bentley, J. Milton Harris, Zhihao Fang, Tacey Viegas
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Publication number: 20100249368Abstract: The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.Type: ApplicationFiled: September 29, 2008Publication date: September 30, 2010Applicant: SERINA THERAPEUTICS, INC.Inventors: J. Milton Harris, Michael David Bentley, Kunsang Yoon, Zhihao Fang