Patents Assigned to Serono Genetics Institute, S.A.
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Publication number: 20110165166Abstract: The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds which can be used as medicament for the prevention and/or treatment of pathologies and/or of pathogeneses such as obesity and anorexia, hyperlipidemias, atherosclerosis, diabetes, hypertension, and more generally the various pathologies associated with abnormalities in the metabolism of cytokines.Type: ApplicationFiled: February 3, 2011Publication date: July 7, 2011Applicants: Serono Genetics Institute S.A., Institut National De La Sante Et De La Recherche Medicale (INSERM)Inventors: BERNARD BIHAIN, Lydie Bougueleret, Frances Yen-Potin
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Publication number: 20110159041Abstract: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides.Type: ApplicationFiled: February 28, 2011Publication date: June 30, 2011Applicant: SERONO GENETICS INSTITUTE S.A.Inventors: Remy Griffais, Susan K. Hoiseth, Robert J. Zagursky, Benjamin J. Metcalf, Joel A. Peek, Banumathi Sankaran, Leah D. Fletcher
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Patent number: 7919091Abstract: The present invention relates to antibodies specific for a receptor termed the Lipolysis Stimulated Receptor (LSR). Compositions comprising the antibodies are also provided.Type: GrantFiled: September 27, 2007Date of Patent: April 5, 2011Assignees: Serono Genetics Institute S.A., Institut National de la Sante Et de la Recherche Medicale (Inserm)Inventors: Bernard Bihain, Lydie Bougueleret, Frances Yen-Potin
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Patent number: 7910329Abstract: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides.Type: GrantFiled: June 25, 2009Date of Patent: March 22, 2011Assignee: Serono Genetics Institute S.A.Inventors: Rémy Griffais, Susan K. Hoiseth, Robert J. Zagursky, Benjamin J. Metcalf, Joel A. Peek, Banumathi Sankaran, Leah D. Fletcher
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Patent number: 7838241Abstract: The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.Type: GrantFiled: December 30, 2008Date of Patent: November 23, 2010Assignee: Serono Genetics Institute S.A.Inventors: Marta Blumenfeld, Ilya Chumakov, Lydie Bougueleret
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Patent number: 7671024Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. The application is related to OBG3 polypepide fragments and compositions comprising these fragments. It also discloses methods of reducing free fatty acid levels with the polypeptide fragments of the invention.Type: GrantFiled: May 23, 2008Date of Patent: March 2, 2010Assignee: Serono Genetics Institute S.A.Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
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Publication number: 20090274719Abstract: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides.Type: ApplicationFiled: June 25, 2009Publication date: November 5, 2009Applicant: SERONO GENETICS INSTITUTE S.A.Inventors: REMY GRIFFAIS, SUSAN K. HOISETH, ROBERT JOHN ZAGURSKY, BENJAMIN J. METCALF, JOEL A. PEEK, BANUMATHI SANKARAN, LEAH DIANE FLETCHER
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Publication number: 20090274701Abstract: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides.Type: ApplicationFiled: June 25, 2009Publication date: November 5, 2009Applicant: Serono Genetics Institute S.A.Inventors: REMY GRIFFAIS, Susan K. Hoiseth, Robert John Zagursky, Benjamin J. Metcalf, Joel A. Peek, Banumathi Sankaran, Leah Diane Fletcher
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Publication number: 20090263847Abstract: The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds which can be used as medicament for the prevention and/or treatment of pathologies and/or of pathogeneses such as obesity and anorexia, hyperlipidemias, atherosclerosis, diabetes, hypertension, and more generally the various pathologies associated with abnormalities in the metabolism of cytokines.Type: ApplicationFiled: September 27, 2007Publication date: October 22, 2009Applicants: Serono Genetics Institute S.A., Institut National de la Sante et de la Recherche Medicale (Inserm)Inventors: BERNARD BIHAIN, Lydie Bougueleret, Frances Yen-Potin
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Patent number: 7601531Abstract: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia pneumoniae, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia pneumoniae genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia pneumoniae infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides.Type: GrantFiled: March 2, 2006Date of Patent: October 13, 2009Assignee: Serono Genetics Institute S.A.Inventors: Rémy Griffais, Susan K. Hoiseth, Robert J. Zagursky, Benjamin J. Metcalf, Joel A. Peek, Banumathi Sankaran, Leah D. Fletcher
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Patent number: 7575913Abstract: The subject of the invention is the genomic sequence and the nucleotide sequences encoding polypeptides of Chlamydia trachomatis, such as cellular envelope polypeptides, which are secreted or specific, or which are involved in metabolism, in the replication process or in virulence, polypeptides encoded by such sequences, as well as vectors including the said sequences and cells or animals transformed with these vectors. The invention also relates to transcriptional gene products of the Chlamydia trachomatis genome, such as, for example, antisense and ribozyme molecules, which can be used to control growth of the microorganism. The invention also relates to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Chlamydia trachomatis infection. The invention also relates to a method of selecting compounds capable of modulating bacterial infection and a method for the biosynthesis or biodegradation of molecules of interest using the said nucleotide sequences or the said polypeptides.Type: GrantFiled: March 2, 2006Date of Patent: August 18, 2009Assignee: Serono Genetics Institute S.A.Inventors: Rémy Griffais, Susan K. Hoiseth, Robert J. Zagursky, Benjamin J. Metcalf, Joel A. Peek, Banumathi Sankaran, Leah D. Fletcher
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Publication number: 20090155806Abstract: The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.Type: ApplicationFiled: December 30, 2008Publication date: June 18, 2009Applicant: SERONO GENETICS INSTITUTE S.A.Inventors: MARTA BLUMENFELD, ILYA CHUMAKOV, LYDIE BOUGUELERET
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Patent number: 7547771Abstract: The invention concerns the geNo.mic sequence and cDNA sequences of the PCTA-1 gene. The invention also concerns biallelic markers of the PCTA-1 gene and the association established between these markers and prostate cancer. The invention provides means to determine the predisposition of individuals to prostate cancer as well as means for the diagNo.sis of prostate cancer and for the progNo.sis/detection of an eventual treatment response to agents acting against prostate cancer.Type: GrantFiled: May 27, 2004Date of Patent: June 16, 2009Assignee: Serono Genetics Institute S.A.Inventors: Marta Blumenfeld, Lydie Bougueleret, Ilya Chumakov
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Publication number: 20090099076Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, globular OBG3, has been identified that reduces weight gain in animals. This compound should be effective for reducing body mass and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidermias, atherosclerosis, diabetes, and hypertension.Type: ApplicationFiled: May 23, 2008Publication date: April 16, 2009Applicant: Serono Genetics Institute S.A.Inventors: Joachim Fruebis, Mary Ruth Erickson, Frances Yen-Potin, Bernard Bihain
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Patent number: 7494777Abstract: The invention concerns the genomic sequence of the FLAP gene. The invention also concerns biallelic markers of a FLAP gene and the association established between these markers and diseases involving the leukotriene pathway such as asthma. The invention provides means to determine the predisposition of individuals to diseases involving the leukotriene pathway as well as means for the diagnosis of such diseases and for the prognosis/detection of an eventual treatment response to agents acting on the leukotriene pathway.Type: GrantFiled: August 29, 2006Date of Patent: February 24, 2009Assignee: Serono Genetics Institute S.A.Inventors: Marta Blumenfeld, Ilya Chumakov, Lydie Bougueleret
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Patent number: 7470669Abstract: The present invention is drawn to methods of screening for new compounds for the treatment of obesity and obesity-related diseases and disorders, as well as methods of treating obesity-related diseases and disorders, based on the discovery of the role of the leptin-LSR interaction in obesity.Type: GrantFiled: September 27, 2005Date of Patent: December 30, 2008Assignee: Serono Genetics Institute, S.A.Inventors: Frances Yen, Mary Ruth Erickson, Joachim Fruebis, Bernard Bihain
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Patent number: 7459433Abstract: The present invention relates to the field of obesity research. Obesity is a public health problem that is serious and widespread. A compound, homotrimer of OBG3 polypeptide fragment comprising globular domain and all or part of OBG3 collagen-like region, has been identified that has utility for reducing body mass, for maintaining weight loss, and for treating obesity-related diseases and disorders. These obesity-related diseases and disorders include hyperlipidemias, atherosclerosis, diabetes, and hypertension.Type: GrantFiled: May 26, 2003Date of Patent: December 2, 2008Assignee: Serono Genetics Institute, S.A.Inventors: John Lucas, Jiunn-chern Yeh, Deno Dialynas
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Patent number: 7449543Abstract: The invention relates to polynucleotides of the PAPAP gene, polypeptides encoded by the PAPAP gene, and antibodies directed specifically against such polypeptides. The invention also concerns methods for the treatment or diagnosis of schizophrenia, bipolar disorder or related CNS disorder. The invention also concerns the interaction of PAPAP with schizophrenia candidate gene g34872.Type: GrantFiled: March 30, 2007Date of Patent: November 11, 2008Assignee: Serono Genetics Institute S.A.Inventors: Bernard Bihain, Barbara Bour, Lydie Bougueleret
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Method for enhancing the efficiency of an enzymatic process for removal of contaminating nucleotides
Patent number: 7449304Abstract: This invention relates to methods for enhancing the efficiency of biological processes that involve successive enzymatic reactions. More specifically, the invention relates to methods for enhancing the efficiency of an enzymatic purification process by increasing the temperature between successive enzymatic purification steps.Type: GrantFiled: October 14, 2002Date of Patent: November 11, 2008Assignee: Serono Genetics Institute S.A.Inventor: Jan Sudor -
Publication number: 20080274971Abstract: The present invention relates to the field of muscle research, in particular to the discovery of a compound effective for increasing muscle mass, muscle cell differentiation, and oxidation of free fatty acids in muscle, useful in methods of treating muscle-related diseases and disorders as well as for augmenting muscle mass in general. The muscle-related diseases or disorders envisaged to be treated by the methods of the invention include, but are not limited to, muscular dystrophy, and other conditions resulting in muscle atrophy or muscle wasting.Type: ApplicationFiled: June 27, 2008Publication date: November 6, 2008Applicant: SERONO GENETICS INSTITUTE S.A.Inventors: Harvey Lodish, Joachim Fruebis, Tsu-Shuen Tsao, Bernard Bihain