Patents Assigned to Serum Institute of India Private Ltd.
  • Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof
    Patent number: 10729780
    Abstract: The present invention provides methods for preparation of stable multivalent pneumococcal polysaccharide-protein conjugate vaccine formulations. Instant stable formulations show optimal percent adsorption for each conjugate wherein, aggregation can be prevented by employing i) Individual or separate adsorption for conjugates that otherwise show lower percent adsorption by combined adsorption ii) Histidine-Succinic acid buffer system along with shift in pH from neutral pH to acidic pH iii) a polysaccharide to protein ratio between 0.5 to about 1.4 iv) a six-bladed Rushton type turbine impeller in formulation vessels.
    Type: Grant
    Filed: June 3, 2016
    Date of Patent: August 4, 2020
    Assignee: Serum Institute of India Private Ltd.
    Inventors: Rajeev Mhalasakant Dhere, Hitesh Kumar Malviya, Swapan Kumar Jana, Sambhaji Shankar Pisal, Asha Dinesh Mallya, Sunil Mahor, Manish Maheshkumar Gautam, Chetan Vilas Joshi, Venkata Vamsi Krishna Malepati, Prashant Shivaji Jadhav
  • Production of high yields of bacterial polysaccharides
    Patent number: 9580734
    Abstract: The instant invention provides improved culture, fermentation and purification conditions for preparing Neisseria meningitidis polysaccharides. The invention in particular relates to a novel fermentation medium, optimal feed solution addition strategies and an improved purification process devoid of any chromatographic methods for obtaining high yield of Neisseria meningitidis X polysaccharide.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: February 28, 2017
    Assignee: Serum Institute of India Private Ltd.
    Inventors: Pisal Sambhaji Shankar, Chilukuri Srinivas Reddy, Peddireddy Srinivas Reddy