Patents Assigned to Serum Institute of India Pvt. Ltd.
  • Methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof
    Patent number: 11793869
    Abstract: The present invention is directed to improved methods of Enterovirus inactivation by formaldehyde in presence of tromethamine buffer resulting in maximum recovery of D-antigen. Subsequent adsorption of said sIPV on aluminium hydroxide provides significantly dose reduced sIPV compositions.
    Type: Grant
    Filed: October 10, 2019
    Date of Patent: October 24, 2023
    Assignee: Serum Institute Of India Pvt Ltd.
    Inventors: Rajeev Mhalasakant Dhere, Sambhaji Shankar Pisal, Jagdish Kamalaji Zade, Rajendra Narayan Sabale, Hitesh Kumar Malviya, Sunil Mahor, Chetan Vilasrao Joshi
  • Immunogenic composition having improved stability, enhanced immunogenicity and reduced reactogenicity and process for preparation thereof
    Patent number: 11179453
    Abstract: An immunogenic composition comprising of Diphtheria toxoid antigen (D), tetanus toxoid (T) antigen, Hepatitis B surface antigen (HBsAg), inactivated whole-cell B. pertussis (wP) antigen, Haemophilus influenzae type B (Hib) capsular saccharide conjugated to a carrier protein, Inactivated Polio Virus (IPV) antigen and additionally one or more antigens and the method of preparing the same. A fully liquid combination vaccine, showing improved immunogenicity, reduced reactogenicity and improved stability. Improved methods of formaldehyde inactivation, improved adsorption profile of Diphtheria toxoid antigen (D), tetanus toxoid (T) antigen and Hepatitis B (HepB) surface antigen adsorbed individually onto aluminium phosphate adjuvant, minimum total aluminum content (Al3+) and optimized concentration of 2-phenoxyethanol (2-PE) as preservative.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: November 23, 2021
    Assignee: SERUM INSTITUTE OF INDIA PVT LTD
    Inventors: Rakesh Kumar, Inder Jit Sharma, Anil Vyankatrao Shitole, Manohar Doddapaneni, Hitt Jyoti Sharma
  • Methods for enterovirus inactivation, adjuvant adsorption and dose reduced vaccine compositions obtained thereof
    Patent number: 10485862
    Abstract: The present invention is directed to improved methods of Enterovirus inactivation by formaldehyde in presence of tromethamine buffer resulting in maximum recovery of D-antigen. Subsequent adsorption of said sIPV on aluminium hydroxide provides significantly dose reduced sIPV compositions.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: November 26, 2019
    Assignee: SERUM INSTITUTE OF INDIA PVT LTD
    Inventors: Rajeev Mhalasakant Dhere, Sambhaji Shankar Pisal, Jagdish Kamalaji Zade, Rajendra Narayan Sabale
  • Adjuvant formulations and methods
    Patent number: 9700615
    Abstract: The present invention is directed to methods for administering antigenic material to a patient as a vaccine against an infection comprising providing both an antigenic material specific to the desired immunological response desired plus an adjuvant comprised of a peptide of a sequence derived from the sequence of pneumococcal surface adhesin A protein (PsaA). Preferably the peptide comprises a sequences derived from one or more sequences of PsaA that contain the epitope regions or contiguous amino acids of SEQ ID NOs 1 or 2. The invention is also directed to vaccine compositions containing adjuvant of the invention and also adjuvant compositions of the invention.
    Type: Grant
    Filed: May 13, 2013
    Date of Patent: July 11, 2017
    Assignee: Serum Institute of India Pvt. Ltd.
    Inventor: Subhash V. Kapre