Abstract: A system and method of investing and reallocating fund assets include investing assets in a first class in a fund having substantially a single asset class at any given time. The system and method further include determining whether a signal is given to reallocate the assets to a second asset class different from the first asset class, and reallocating the assets in the fund to the second asset class if the signal is given to reallocate the assets. In embodiments of the invention, the fund is diversified among different asset classes over time rather than at any instant.

Abstract: Various embodiments of the present invention provide systems and methods for storing electronic documents. In particular, various embodiments provide systems and methods that use profiles defining one or more attributes to generate file names and folders for storing the electronic documents. Further embodiments provide systems and methods for storing one or more records related to the electronic documents in one or more tables based on the profiles. In various embodiments, these records are used to manage the storage of the documents in the system and to help in locating and retrieving the documents from the system.

Abstract: An automatic gain control circuit including a variable gain amplifier (11) adapted to receive a received signal (R) and to output an amplified signal (A) to an analog to digital converter (20), and a gain controller (12) which is connected to said variable gain amplifier (11) for receiving said amplified signal (A) and for controlling a gain of said variable gain amplifier (11). The gain controller (12) is adapted to determine an occurrence of a threshold event each time the amplified signal (A) has reached a predetermined threshold, decrease the gain of the variable gain amplifier (11) at each occurrence of a threshold event, measure a delay since the last threshold event, increase the gain of the variable gain amplifier (11) if the delay is greater than a delay specified value and if the gain of the variable gain amplifier (11) is not maximum.

Abstract: The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.

Abstract: An automated banking machine is controlled responsive to data read from data bearing records. The automated banking machine includes a card reader, a keypad, a cash dispenser, a cash outlet, a deposit accepting opening, and other transaction locations that may be susceptible to the installation of fraud devices. An anti-fraud sensing system is operative in the machine to sense the probable installation of unauthorized devices on the machine. Such unauthorized devices may include for example, fraudulent card reading devices, fraudulent keypad input intercepting devices, cash outlet trap devices, and deposit input diversion devices.

Abstract: An automated banking machine operates to carry out financial transfers responsive to data read form data bearing records. The machine includes a card reader that operates to read data from user cards. The card data corresponds to financial accounts. The automated banking machine further includes a cash dispenser. The machine is operative to dispense cash to an authorized user based on identifying data including card data, and to cause a financial transfer from an account corresponding to card data through communication with at least one remote computer. The machine is operative to authorize the installation, use, and/or configuration of automated banking machine software applications and components.

Abstract: A system monitors each of multiple applications. For each application, a corresponding monitoring script sets forth procedures for monitoring the application. A script execution engine executes each script, and each executed script retrieves indicia to be monitored from the corresponding application. For each retrieved indicia, the script generates a corresponding record in a generic format employed across all applications, which includes a date and time the indicia was retrieved, a name of the application from which the indicia was retrieved, a name of the indicia, and a value for the retrieved indicia. A monitoring database stores the records generated by each script in the generic format. A generic monitoring console retrieves various records in the generic format from the monitoring database for various ones of the multiple applications and displays monitoring information for various ones of the multiple applications as generated from the various records.

Abstract: The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.

Abstract: Methods and devices are provided for accurately determining depths of certain structures in downhole strings. Locator tools comprise a shaft and a plurality of locator springs longitudinally mounted on the shaft. The locator springs are biased to expand and are configured to compress to allow the tool to traverse past restrictions in the downhole string. Each locator spring includes a locating pad that allows it to engage with an internal locating notch in the downhole string. The internal locating notch is sized to mate with the locator tool, i.e., to allow the locator springs to engage the internal locating notch. In this way, the depth of internal locating notches may be determined precisely and accurately by sensing engagement of the tool with the internal locating notch. Advantages of certain embodiments include more accurate depth determination, repeatable engagements of the tool, and reduced false engagements.

Abstract: A method of enhancing an antigen-specific immune response in a host comprising administering to the host an HMGN polypeptide comprising at least one of HMGN1, HMGN3a, HMGN3b, HMGN4, Nsbp1, or a functional fragment thereof, in an amount effective to enhance an antigen-specific immune response; as well as a pharmaceutical composition comprising an HMGN polypeptide comprising at least one of HMGN1, HMGN3a, HMGN3b, HMGN4, Nsbp1, or a functional fragment thereof, and an antigen, or nucleic acids encoding such molecules; and related methods and compositions.

Abstract: D type CpG oligodeoxynucleotides are provided herein that include a sequence represented by the following formula: 5?X1X2X3Pu1Py2CpGPu3Py4X4X5X6(W)M(G)N-3? wherein the central CpG motif is unmethylated, Pu is a purine nucleotide, Py is a pyrimidine nucleotide, X and W are any nucleotide, M is any integer from 0 to 10, and N is any integer from 4 to 10. Methods of using these oligodeoxynucleotides to induce an immune response are provided.

Abstract: A method for monitoring and detecting coating defects in a defined section of a coated underground or underwater pipeline provided with a monitoring unit fixedly mounted by sections and at the end of the respective section and an apparatus used in the method.

Abstract: A person may store food to prepare for an emergency. An insurance policy may be issue to cover the stored food against loss, theft, spoilage, etc. In issuing the insurance policy and setting the premium, the insurer may take various factors into account, such as the type of food to be stored (e.g., canned, dried, etc.), where the food is to be stored (e.g., a cellar, a closet, a food locker, etc.), and whether the stored food is rotated with new food to prevent the stored food from spoiling due to age. During the life of the insurance policy, the insurer may issue alerts to the policyholder in order to advise the policyholder to rotate old food out of storage.

Abstract: A new Rhenium alloy usable for improving the performance of emission filaments used in mass spectrometers or other similar scientific instruments, which is made by adding low level concentrations of Yttrium Oxide to Rhenium of less than 10%. This new alloy has demonstrated superior performance characteristics compared to pure Rhenium for this purpose. Filaments made from the Yttria/Rhenium alloy exhibit the same voltage, current and emission properties as Rhenium but have the added advantage of greatly decreasing warping during use. The Rhenium alloy filaments are usable with various shapes and configurations including straight filaments, multiple coiled filaments and pin shaped filaments. Electron microscopy and microscopy studies verify that the Yttria/Rhenium material of the new alloy has a smaller grain size and increased strength when compared to pure Rhenium, which accounts for the enhanced structural strength.

Abstract: A roof mounting system can include a roof substrate and flashing supportable on the substrate and including an outwardly extending projection having a concave interior side and an aperture extending through the projection between top and bottom surfaces of the flashing. A seal can extend through the aperture and contact at least a portion of the top surface and at least a portion of the bottom surface. The seal can be conformable with the concave interior side and can define a seal aperture substantially aligned with the flashing aperture. A mounting bracket can be supportable on the flashing and can define an aperture sized to receive at least a portion of each of the seal and the projection. A fastener can extend through the mounting bracket aperture, seal aperture, and flashing aperture to inhibit fluid flow through the flashing aperture.

Abstract: A method of making a heater structure and a corresponding heater structure are disclosed. The method comprises providing a porous reinforcement material such as glass cloth, applying a metal to the porous reinforcement material such as by spraying and applying resin to the porous reinforcement material with metal already applied thereto to make the structure substantially rigid. Applying the metal to the porous reinforcement material before applying the resin provides a number of advantages such as enhanced shear strength between the porous reinforcement material and the applied metal layer and the ability to manipulate the porous reinforcement material with metal applied thereto prior to applying the resin. The heater structure may be used in many applications, some of which arc described.

Abstract: A system controlled responsive to data bearing records includes a card reader that is operative to read card data from user cards including identifying data, and authorizes operation of an automated banking machine responsive to the identifying data. The banking machine can generate a check in response to user inputs. The banking machine can also present the check to the machine user. The banking machine can present an interface for the user to sign the check. The user's banking account is charged an amount corresponding to the check value. In exchange for the same banking machine receiving the generated check, the user is provided with cash dispensed from the banking machine. The banking machine also allows a user to select having a canceled check image displayed at the machine and/or sent to the user's network address.

Abstract: A pressurizable chamber device or containment vessel and method of use thereof. The device or vessel includes two chamber portions, a lid portion and a base portion, drawn to one another via a nut portion. The lid and base portions each include concave surfaces that matingly fit together, such that an internal chamber is formed when these portions are fit together. The lid and base portions each include a flange having a groove therein, such that a flexible seal element is fittable into the groove. The lid and base portions include features to matingly engage the nut portion, such that engagement thereamong draws the lid portion and the base portion toward one another, tightly sealing the formed internal chamber. A pressure, such as a resin pressure that may be precisely regulated, may then be applied, for example, to a mold contained within the formed and tightly sealed chamber.

Abstract: Systems and methods for process optimization pertaining to Suppliers-Inputs-Process-Outputs-Customers (SIPOC) diagram for different processes optimization are described herein. In one implementation, a process optimization system is utilized for process optimization. The process optimization system comprises a processor, and a memory. The memory comprises a comparison module and an evaluation module. The evaluation module is configured to receive one or more evaluation parameters and evaluate a rating score for at least one attribute based at least in part on the one or more evaluation parameters. The comparison module is configured to determine one or more benchmark parameters based on the rating score, and provide one or more benchmark parameters.

Abstract: The invention provides containers and methods of use for the storage, transportation and preparation of samples, such as DNA samples for analysis. The container is pre-provided with the reagents in sealed chambers. The sample can be introduced and the container manipulated to release the reagents, provide the necessary conditions and give a fully prepared sample. The container can then be engaged with an analysis device to identify characteristics of the sample or perform other operations thereon.