Patents Assigned to SETA BioMedicals, LLC
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Patent number: 11091646Abstract: Luminescent reporter compounds that are rotaxanes having the structure where B—Z—C is a reporter molecule based on a squaraine type molecule, or similar reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.Type: GrantFiled: August 13, 2018Date of Patent: August 17, 2021Assignee: SETA BioMedicals, LLCInventors: Dmytro V. Kobzev, Olga S. Kolosova, Olena M. Obukhova, Olga M. Semenova, Rostyslav P. Svoyakov, Anatoliy L. Tatarets, Ewald A. Terpetschnig
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Patent number: 9841428Abstract: Disclosed viscosity-sensitive reporter compounds and methods allow tracing the changes in viscosity in a biological sample/environment (e.g., in medical, biochemical, biological, and/or pharmaceutical applications). Compounds and methods of the present disclosure can be used to identify the localization and the rheological state of hydrogels, their degradation products and other biostructural materials, including surgical implants, as well as the effectiveness of drug delivery by hydrogel carriers.Type: GrantFiled: September 25, 2015Date of Patent: December 12, 2017Assignee: SETA BioMedicals, LLCInventors: Tetiana Vitaliivna Shkand, Mykola Oleksiiovych Chyzh, Iryna Vadymivna Sleta, Anatoliy Leonidovich Tatarets, Oleksandr Davydovych Roshal, Leonid Davidovych Patsenker, Borys Petrovych Sandomyrskiy, Ewald Alois Terpetschnig
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Patent number: 9110069Abstract: Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkages selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye or a styryl dye.Type: GrantFiled: October 7, 2013Date of Patent: August 18, 2015Assignee: SETA BioMedicals, LLCInventors: Ewald A. Terpetschnig, Leonid D. Patsenker, Larysa Markova, Iryna A. Fedyunyaeva, Olga S. Kolosova, Olena M. Obukhova, Anatoliy Tatarets
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Patent number: 9034655Abstract: Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.Type: GrantFiled: October 18, 2010Date of Patent: May 19, 2015Assignee: SETA BioMedicals, LLCInventors: Leonid D. Patsenker, Inna G. Yermolenko, Iryna A. Fedyunyaeva, Yelena N. Obukhova, Olga N. Semenova, Ewald A. Terpetschnig
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Publication number: 20140200333Abstract: Dendronic reporters are described which incorporate a high density of luminescent or non-luminescent dyes at periphery sites and a focal point group that is reactive, ionic or a conjugated substance. Such dendronic reporters are capable of sensing analytes, or are otherwise useful in luminescent assays. Additionally, methods of synthesis are described.Type: ApplicationFiled: August 14, 2012Publication date: July 17, 2014Applicant: SETA BIOMEDICALS, LLCInventors: Ewald Terpetschnig, Inna G. Yermolenko, Olena M. Obukhova, Anatoliy Tatarets, Leonid D. Patsenker
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Publication number: 20140086844Abstract: Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkages selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye or a styryl dye.Type: ApplicationFiled: October 7, 2013Publication date: March 27, 2014Applicant: SETA BIOMEDICALS, LLCInventors: Ewald A. Terpetschnig, Leonid D. Patsenker, Larysa Markova, Iryna A. Fedyunyaeva, Olga S. Kolosova, Sergiy Starko, Anatoliy Tatarets
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Patent number: 8642014Abstract: Luminescent reporter compounds that are rotaxanes having the structure where B—Z—C is a reporter molecule based on a cyanine, squaric acid, or other reporter, and K is a macrocycle that encircles and interlocks with the reporter molecule. Applications of the reporter compounds are provided, as well as reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing the reporter compounds.Type: GrantFiled: July 30, 2009Date of Patent: February 4, 2014Assignee: SETA BioMedicals, LLCInventors: Ewald A. Terpetschnig, Leonid D. Patsenker, Oleksii Klochko, Yuliia Kudriavtseva, Anatoliy L. Tatarets, Inna G. Yermolenko, Yevgen A. Povrozin
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Patent number: 8552027Abstract: Dyes and photoluminescent compounds based on polymethine dyes that contain at least one alkyl-phosphonate or substituted alkyl-phosphonate group, including the synthetic precursors, methods of synthesis, and applications thereof. Certain embodiments include heterocyclic ring systems and polymethine linkage are selected such that the resulting polymethine dye is a cyanine dye, a merocyanine dye, or a styryl dye.Type: GrantFiled: January 15, 2010Date of Patent: October 8, 2013Assignee: SETA BioMedicals, LLCInventors: Ewald A. Terpetschnig, Leonid D. Patsenker, Larsya Markova, Iryna A. Fedyunyaeva, Olga S. Kolosova, Sergiy Starko, Anatoliy Tatarets