Abstract: Provided is a polypeptide compound which is X-ID-Y or Y-ID-X, wherein X is a calcium-sensing receptor agonist; ID is a disulfide bond or linker arm within molecules and links X and Y; and Y is a bone growth peptide receptor agonist or a bone marrow mesenchymal stem cell stimulator. Also provided are a pharmaceutical composition comprising the polypeptide compound and a use of the compound and pharmaceutical composition.