Patents Assigned to Shanbrom Technologies, LLC
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Patent number: 8389687Abstract: Blood collection, processing and transfer leads to the separation of discrete fractions by adding additional citrate (trisodium citrate) to bring the citrate concentration to 10%-15% w/v thereby leading to enhanced yield and purity of cryoprecipitate. The improved cryoprecipitate then yields concentrated clotting factors by an improved extraction process which uses polyvinyl pyrollidone to reduce the extraction of fibrinogen. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds.Type: GrantFiled: October 31, 2007Date of Patent: March 5, 2013Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 8003706Abstract: The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products. The inventive process is particularly suited to an improved extraction process to yield concentrated clotting factors from single donors or limited pools without use of chromatography. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds.Type: GrantFiled: July 28, 2008Date of Patent: August 23, 2011Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Publication number: 20100233672Abstract: Special extracts of grape berries and Goji berries can be prepared by exposing fruit juices or preparations to an insoluble binding resin which is then extracted with soluble polyvinylpyrollidone. Grape and Goji extracts made in this way can be used to inhibit or control platelet aggregation. Grape extract has exceptional antibacterial properties and can be used to control oral bacteria and to control MRSA (Methicillin-resistant Staphylococcus aureus). The combination of control of platelet aggregation and antibacterial properties exhibited by the grape-extract allows it to be used to significantly extend the life of isolated platelets. When added to solutions of isolated platelets, the grape extract prevents bacterial growth and prevents deterioration of the platelets through activation. This treatment extends the usable life of platelet concentrates to at least ten days. In addition, polyphenols can be used as a medicament for modulation of platelet activity in vitro.Type: ApplicationFiled: November 6, 2008Publication date: September 16, 2010Applicant: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Publication number: 20090123907Abstract: An improved anticoagulant or additive is based on a higher level of citric acid than is usual (at least about 1.0% weight by volume). The higher citrate is combined with an amino acid as a counterion. The amino acid prevents cellular damage often caused by elevated citrate levels. The amino acid citrate mixture also serves to preserve platelet concentrates and platelet rich plasma during room incubation. Not only does the amino acid citrate combination enhance platelet integrity, it completely inhibits or kills bacteria such as Staphylococcus epidermidis. Collecting blood of plasma into such higher levels of citrate prevents activation of blood proteins so that fractions made from the blood or plasma have superior characteristics.Type: ApplicationFiled: July 22, 2005Publication date: May 14, 2009Applicant: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 7411006Abstract: The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 9% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products. The inventive process is particularly suited to an improved extraction process to yield concentrated clotting factors from single donors or limited pools without use of chromatography. Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in the treatment of wounds.Type: GrantFiled: June 12, 2003Date of Patent: August 12, 2008Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 7297716Abstract: The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 2% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products, which include fibrin glue, is achieved. In addition, the process allows “cryo” precipitate to be prepared at temperatures above freezing and without freezing the plasma.Type: GrantFiled: October 25, 2002Date of Patent: November 20, 2007Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6881731Abstract: Simple carboxylic acids, in particular dicarboxylic acids such as citric acid shows an unexpected ability to enhance the antimicrobial power of a wide range of disinfectant and/or antibiotic agents. As little as 1% citrate greatly enhances the ability of antibiotics to kill or inhibit a wide range of bacterial species including antibiotic resistant strains. Citrate alone is effective in preventing bacterial growth in platelet concentrates and in red blood cell suspensions. Effective concentrations of citrate cause little if any damage to blood cells. Besides enhancing the power of antibiotics citrate also enhances the antimicrobial properties of disinfectant organic dyes such as crystal violet and methylene blue. In addition citrate enhances the antimicrobial properties of polyphenols of plant origin. Iodine-based disinfectants are also enhanced without enhancing protein denaturation.Type: GrantFiled: October 23, 2000Date of Patent: April 19, 2005Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6863905Abstract: A mixed bed of iodine source/iodine capture resin provides high flow rates that are useful for treatment of water. The ratio of source/capture resin can be adjusted to meet the goals of the system. If insufficient iodine is being provided, the source resin amount can be increased relative to the capture resin. If excess iodine or iodide are found in the treated water, the capture resin amount can be increased relative to the source resin. The release of iodine from the source resin and its effectiveness can be significantly enhanced by using a mixed bed system in which one or both of the source and the capture ion exchange resins have had their exchange sites saturated with the anion of an organic acid such as citrate and/or isocitrate. This significantly increases the amount of iodine released into aqueous solution and enhances the disinfecting power of that iodine.Type: GrantFiled: May 21, 2002Date of Patent: March 8, 2005Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6841060Abstract: A simple analytical method for determining antioxidant level in food product and body fluids such as urine is based on reduction of elemental iodine. The method adds an aqueous solution of iodine and an iodophor to the sample to be tested. Polyvinylpyrrolidone is a preferred iodophor. Antioxidant materials in the sample reduce the elemental iodine and the reaction is monitored by measuring either a decrease in iodine or an increase in iodide ion. A preferred method of practicing the invention is to measure the change in iodide ion with an ion selective electrode and an appropriate electronic meter. The method rapidly and inexpensively produces antioxidant measurements that are comparable to those produced by my more complex and cumbersome methods.Type: GrantFiled: May 20, 1999Date of Patent: January 11, 2005Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6821533Abstract: The lees or “dregs” produced during wine making are rich sources of antioxidants. Unexpectedly, these materials show significant antibacterial properties as well as antioxidant properties. The lees of red wine which consist of tannins and plant pigments precipitated around crystals of potassium tartarate can advantageously be used directly as a tonic or demulcent. The material can also be used topically for disinfecting the skin, etc. In addition, it is possible to use organic polymers to bind the pigments and/or solubilize them from the tartaric salt to facilitate their use or to make a relatively pure pigment/tannin component.Type: GrantFiled: April 9, 2003Date of Patent: November 23, 2004Assignee: Shanbrom Technologies LLCInventor: Edward Shanbrom
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Publication number: 20030198699Abstract: The lees or “dregs” produced during wine making are rich sources of antioxidants. Unexpectedly, these materials show significant antibacterial properties as well as antioxidant properties. The lees of red wine which consist of tannins and plant pigments precipitated around crystals of potassium tartarate can advantageously be used directly as a tonic or demulcent. The material can also be used topically for disinfecting the skin, etc. In addition, it is possible to use organic polymers to bind the pigments and/or solubilize them from the tartaric salt to facilitate their use or to make a relatively pure pigment/tannin component.Type: ApplicationFiled: April 9, 2003Publication date: October 23, 2003Applicant: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6610316Abstract: A detergent such as nonionic, cationic or anionic detergents and preferably a “sugar detergent” such as octyl-glucopyranoside is rendered insoluble by being bound to an inert substrate. This detergent is effective at inactivating pathogens even when so bound. Under these conditions the concentration of detergent free in solution is vanishingly low: probably below one millimolar in concentration. Addition of insoluble detergent results in effective destruction of enveloped viruses in a variety of protein containing solutions such as blood, plasma, clotting factors or other proteins purified from human blood. Because the detergent is essentially entirely bound to the solid substrate, there is little or no difficulty in ensuring that the end product is detergent-free. Because the detergent is so bound, it causes essentially no damage to proteins, blood cells and other cellular material.Type: GrantFiled: May 30, 1997Date of Patent: August 26, 2003Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Publication number: 20030129167Abstract: The blood collection, processing and transfer by separation of discrete components containing additional citrate (at least about trisodium citrate 2% w/v) in one or other of collection or processing bag provides for enhanced yield and purity of cryoprecipitate. Inhibiting the activation or denaturation of blood components including blood cells and plasma proteins and with the removal of the activated and denatured components thereby improving safety and efficacy of end products, which include fibrin glue, is achieved. In addition, the process allows “cryo” precipitate to be prepared at temperatures above freezing and without freezing the plasma.Type: ApplicationFiled: October 25, 2002Publication date: July 10, 2003Applicant: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6548076Abstract: The lees or “dregs” produced during wine making are rich sources of antioxidants. Unexpectedly, these materials show significant antibacterial properties as well as antioxidant properties. The lees of red wine which consist of tannins and plant pigments precipitated around crystals of potassium tartarate can advantageously be used directly as a tonic or demulcent. The material can also be used topically for disinfecting the skin, etc. In addition, it is possible to use organic polymers to bind the pigments and/or solubilize them from the tartaric salt to facilitate their use or to make a relatively pure pigment/tannin component.Type: GrantFiled: August 17, 1999Date of Patent: April 15, 2003Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6541518Abstract: Derivatives of simple carboxylic acids, particularly trisodium citrate and other citrate salts are effective agents for enhancing the production of blood clotting factors. Addition of citrate to plasma, especially at concentrations between 2 and 10% by weight, does not appreciably denature labile proteins. However, citrate is effective in inactivating or inhibiting a variety of pathogenic microorganisms. Further, the added citrate potentiates or enhances the killing of microorganisms by heat treatment. The added citrate causes a dramatic increase in the weight of cryoprecipitate that can be produced from plasma by the usual procedures. The majority of significant clotting factors are greatly concentrated in the resulting cryoprecipitate. Increasing the amount of citrate in blood bags so that the final concentration will be at least 2% by weight results in plasma that provides improved platelet concentrates because added citrate helps eliminate contaminating microorganisms.Type: GrantFiled: February 7, 2001Date of Patent: April 1, 2003Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Publication number: 20030022149Abstract: Derivatives of simple carboxylic acids, particularly trisodium citrate and other citrate salts are effective agents for enhancing the production of blood clotting factors. Addition of citrate to plasma, especially at concentrations between 2 and 10% by weight, does not appreciably denature labile proteins. However, citrate is effective in inactivating or inhibiting a variety of pathogenic microorganisms. Further, the added citrate potentiates or enhances the killing of microorganisms by heat treatment. The added citrate causes a dramatic increase in the weight of cryoprecipitate that can be produced from plasma by the usual procedures. The majority of significant clotting factors are greatly concentrated in the resulting cryoprecipitate. Increasing the amount of citrate in blood bags so that the final concentration will be at least 2% by weight results in plasma that provides improved platelet concentrates because added citrate helps eliminate contaminating microorganisms.Type: ApplicationFiled: February 7, 2001Publication date: January 30, 2003Applicant: Shanbrom Technologies, LLCInventor: Edward Shanbrom
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Patent number: 6093401Abstract: An active coloring concentrate can be prepared from the juice of cranberries and blueberries by treating juice or homogenate with an appropriate binding matrix. Assorted ion exchange resins such as cholestyramine are effective binding matrices, but the currently preferred material is a food grade of cross-linked polyvinyl pyrollidone. The binding matrices are used to concentrate active materials from cranberry and a colored solid is produced. This substance shows anti-bacterial and anti-viral properties. It can be readily consumed as a therapeutic or nutraceutical, used as a coloring agent, or it can be used topically. Significant amounts of active concentrate can be produced from cranberry presscake which is normally a waste material.Type: GrantFiled: September 16, 1997Date of Patent: July 25, 2000Assignee: Shanbrom Technologies LLCInventor: Edward Shanbrom
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Patent number: 6045787Abstract: Mixtures of iodine source resin with iodine capture resin have been found to provide effective disinfecting of protein containing solutions such as plasma. These mixtures can be used in a chromatographic manner to effectively disinfect solutions while causing minimal damage to labile proteins such as clotting factors. Mixed resins containing equivalent amount of iodine source and iodine capture (50:50) are effective in many cases. If protein damage is still occurring, the ideal mixture may be one containing a lower amount of iodine (e.g. 25:75 or even 5:95). If disinfecting properties prove inadequate, ratios can be increased (e.g. 80:20). Surprisingly, the mixed resins also spare tissue components such as red blood cells and platelets. In some cases mixed resins are even useful in a batch procedure where the resin is removed by centrifugation or filtration at the end of a treatment period.Type: GrantFiled: September 1, 1998Date of Patent: April 4, 2000Assignee: Shanbrom Technologies LLCInventor: Edward Shanbrom
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Patent number: 6036738Abstract: An improved disinfecting air filter that can be used to disinfect air or other gases. The invention can be advantageously used as a standalone to control microorganisms or used with a traditional HEPA filter to effectively control all microorganisms as well as dust particles. The device contains an iodine-donating filter disposed to dispense an effective quantity of iodine vapor into the gas or air stream to be filtered. The iodine laden air then passes through a porous filter of polyvinyl acetal polymer which material has an unusual affinity for iodine and effectively removes it leaving disinfected and iodine-free air or gas.Type: GrantFiled: December 31, 1997Date of Patent: March 14, 2000Assignee: Shanbrom Technologies LLCInventor: Edward Shanbrom
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Patent number: 5985260Abstract: A method of disinfecting blood, blood components, biologicals, such as plasma, serum, cell concentrates, clotting proteins, etc., as well as tissues and organs for transplant comprising preparing and immediately adding active albumin-iodine complex to the material to be disinfected and thereafter using the disinfected material is disclosed. A modified blood bag for use with active albumin-iodine complex had a small satellite bag to contain albumin or active albumin-iodine complex and may also comprise a flow-through cartridge for preparing the active albumin-iodine complex.Type: GrantFiled: September 18, 1995Date of Patent: November 16, 1999Assignee: Shanbrom Technologies, LLCInventor: Edward Shanbrom