Patents Assigned to Shandong University
  • Patent number: 10416132
    Abstract: A detection method for low molecular weight heparin complete degradation products using hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry. Identifying the original reducing end and non-reducing end of enoxaparin sodium by means of reducing the reducing end of enoxaparin sodium, and performing hydrolysis using hydrogen peroxide. Performing quantitative analysis on all component units utilizing hydrophilic interaction chromatography and multiple reaction monitoring tandem mass spectrometry, in particular quantifying low-content special structures and characterizing low molecular weight heparin.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: September 17, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Lianli Chi, Xiaojun Sun, Anran Sheng, Xinyue Liu
  • Patent number: 10415387
    Abstract: A high-strength confined concrete support system for an underground tunnel. The support system includes multiple confined concrete arches, bolts and cables, and a prestressed steel strand backfilling system. The confined concrete arches all support the surrounding rock of the tunnel and are sequentially arranged along the tunnel. Every two adjacent confined concrete arches are connected by a longitudinal connection structure. The support system is provided with a plurality of layers of steel bar meshes on the surrounding rock side and the tunnel side, and shotcrete layers are sprayed on the support system and the steel bar meshes. The prestressed steel strand backfilling system comprises a prestressed steel strand system and a filling material. The filling material fills the space between each confined concrete arch and the surrounding rock to equalize a load on the confined concrete arch and generate prestress.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: September 17, 2019
    Assignees: SHANDONG UNIVERSITY, SHANDONG TIANQIN MINING MACHINERY EQUIPMENT CO. LTD.
    Inventors: Shucai Li, Qi Wang, Bei Jiang, Yingcheng Luan, Qian Qin, Huibin Sun, Hengchang Yu, Zhaonan Zeng
  • Patent number: 10411628
    Abstract: A servo control strategy and system eliminates CEMF and load torque disturbances. The total disturbance at electrical portion is estimated using extended state observer based on a nominal model of armature winding with measured voltage impressed across two endpoints of armature winding and the measured armature current. The total disturbance at electrical portion is partially counteracted by feed-forward compensation. The remaining CEMF disturbance is eliminated with the aid of armature current feedback regulation. The electrical disturbance can be totally eliminated at inner loop of the system by combining feed-forward control with current feedback control. The total disturbance at mechanical portion is estimated using extended state observer based on a nominal model of drive system with measured armature current and actual speed. The total disturbance at mechanical portion is partially counteracted by feed-forward compensation.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: September 10, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventor: Jinbo Liu
  • Patent number: 10408551
    Abstract: A columnar cooling tube bundle with a wedge-shaped gap, including two finned tube bundles, which intersect at one side with a set angle and open at the other and form a wedge-shaped gap; with the intersection as an origin, a distance l extends to the opening side, the bundles share fins within 0-l, wherein l is no more than half the distance between the two sides. When air inflows vertically to the louver of the cooling unit, fresh air is directly introduced into the cooling tube bundle to improve the average heat transfer temperature difference of the cooling tube bundle and intensify the heat transfer; when air inflows obliquely, it impacts the inner space of the cooling unit, therefore the low-speed eddy area is reduced, both the cooling performance of the tube bundle and cooling unit overall is improved, and the cooling performance of the dry cooling tower is improved.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: September 10, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Yuanbin Zhao, Yujie Yang
  • Patent number: 10408718
    Abstract: A pressure three-dimensional non-uniform loading/unloading and steady pressure model test system has a pressure three-dimensional non-uniform loading/unloading device. The pressure three-dimensional non-uniform loading/unloading device is controlled via an input instruction of the hydraulic loading/unloading and steady pressure automatic control system to carry out pressure three-dimensional gradient non-uniform loading/unloading and steady pressure control. An automatic model displacement test system automatically acquires the displacement of any part inside a test model. A multi-probe peeping system observes a cavern excavation deformation and failure process dynamically in real time.
    Type: Grant
    Filed: April 28, 2017
    Date of Patent: September 10, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Qiangyong Zhang, Chuancheng Liu, Shucai Li, Wen Xiang, Hanpeng Wang, Yue Zhang, Mingyang Ren, Dong Wu
  • Patent number: 10399286
    Abstract: A composite material packaged fiber grating sensor and a manufacturing method thereof. The sensor includes a fiber grating sensor component, a composite material coverage layer, a resin package layer and a composite material substrate layer. In the sensor, a temperature fiber grating and a strain fiber grating are packaged in a composite material structure, so that the structure is light and simple, its computability with the composite material is good, the measurement accuracy is high, and the survival rate and the service life of the installed sensor can be greatly improved, the sensor component can be externally pasted on to or inter-implanted in a composite material structural part, and can be applied to the distributed online health monitoring on the structural part. The manufacturing method of the composite material packaged fiber grating sensor is simple, efficient and stable, and is suitable for rapid mass production by enterprises.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: September 3, 2019
    Assignees: SHANDONG UNIVERSITY, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD.
    Inventors: Yuxi Jia, Yunli Guo, Lijia An, Weiguo Yao, Linlin Gao, Qinglin Wang, Mingshun Jiang, Haiqing Wang, Jieying Zhi, Yaru Zhao, Qingmei Sui
  • Patent number: 10399978
    Abstract: It relates to the imidazopyridine thioglycolic acid derivatives, the preparation, and use thereof. The invention contained imidazopyridine thioglycolic acid derivatives with the formula I or II or III. Also described here are preparation of imidazopyridine thioglycolic acid derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for gout.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: September 3, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Xinyong Liu, Qing Meng, Peng Zhan, Zengjun Fang, Tong Zhao, Zhuosen Sun, Xiukun Sun
  • Patent number: 10385041
    Abstract: A novel terpene derivative-based PAR1 inhibitor, a preparation method thereof and a pharmaceutical composition including the same or a salt thereof, as well as a use of the PAR1 inhibitor and the salt thereof in preparation of medicaments for preventing and/or treating thrombotic diseases. The structural formula of the compound is as follows: The compound has the advantages of clear target, novel structure, low bleeding risk, high safety, outstanding active effect, low preparation cost and the like, and has a great application prospect in the preparation of the medicaments for treating the thrombotic diseases.
    Type: Grant
    Filed: January 14, 2016
    Date of Patent: August 20, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Hongxiang Lou, Bin Sun, Jun Liu
  • Patent number: 10374579
    Abstract: An improved design method of a two-stage FRM filter includes the following steps: constructing an improved two-stage FRM filter; calculating passband and stopband edge parameters of a prototype filter, passband and stopband edge parameters of a second-stage masking filter and passband and stopband edge parameters of a first-stage masking filter in Case A and Case B, respectively; calculating the complexity of the FRM filter according to the obtained parameters, and finding out one or more sets [M, P, Q] having the lowest complexity within a search range; and optimizing the improved FRM filter. The improved design method of a two-stage FRM filter has the following beneficial effect: as compared to a conventional design method of a two-stage FRM filter, the complexity of a narrow-band FIR (Finite Impulse Response) filter can be reduced through design using the improved method, and power consumption is thus reduced in hardware implementation.
    Type: Grant
    Filed: June 19, 2014
    Date of Patent: August 6, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Ying Wei, Shaoguang Huang
  • Publication number: 20190225606
    Abstract: It relates to the imidazopyridine thioglycolic acid derivatives, the preparation, and use thereof. The invention contained imidazopyridine thioglycolic acid derivatives with the formula I or II or III. Also described here are preparation of imidazopyridine thioglycolic acid derivatives, pharmaceutical compositions comprising these compounds as therapy and prevention for gout.
    Type: Application
    Filed: September 2, 2016
    Publication date: July 25, 2019
    Applicant: Shandong University
    Inventors: Xinyong LIU, Qing MENG, Peng ZHAN, Zengjun FANG, Tong ZHAO, Zhuosen SUN, Xiukun SUN
  • Publication number: 20190227349
    Abstract: The present disclosure relates to use of a quaternary molybdenum/tungsten tellurite crystal and a device thereof. The quaternary molybdenum/tungsten tellurite crystal is used as an acousto-optic material, wherein the quaternary molybdenum/tungsten tellurite comprises tellurium (Te) and tungsten (W), or tellurium (Te) and molybdenum (Mo). The crystal has abundant kinds, is non-toxic, and includes high, medium and low symmetry crystal systems; it easily produces a large-size and high-quality single crystal and almost meets all requirements of excellent acousto-optic properties. In the present disclosure, by selecting different light transmission directions and excitation source directions to fabricate an acousto-optic device with practical application values according to the requirements of the crystal acousto-optic device and the crystal characteristics, high-performance acousto-optic Q switching laser output is achieved.
    Type: Application
    Filed: September 30, 2017
    Publication date: July 25, 2019
    Applicant: SHANDONG UNIVERSITY
    Inventors: Xutang TAO, Zeliang GAO, Youxuan SUN, Qian WU
  • Patent number: 10357369
    Abstract: The present application discloses a method of producing a knee replacement implant, an implant for knee replacement formed by using the method, and a knee replacement implant. The method includes: defining a hip center, a knee center, an ankle center and a posterior femoral condylar axis of a lower limb; generating femoral geometric parameters and tibial geometric parameters, the femoral geometric parameters and the tibial geometric parameters being measured in relation to the hip center, the knee center, the ankle center and the posterior femoral condylar axis; collecting anthropometric data from a defined population using the femoral geometric parameters and the tibial geometric parameters; and creating a femoral component and/or a tibial component using the collected anthropometric data.
    Type: Grant
    Filed: August 4, 2016
    Date of Patent: July 23, 2019
    Assignees: Shandong Weigao Orthopaedic Device Co. Ltd., The Chinese University of Hong Kong, Shenzhen Institutes of Advanced Technology, Chinese Academy of Science
    Inventors: Kwok-Sui Leung, Wing-Hoi Cheung, Jianghui Qin, Chun-Sing Chui, Dufang Shi, Kwoon-Ho Chow, Ling Qin, Wanfu Kou, Chenglin Lu
  • Publication number: 20190218910
    Abstract: An asymmetric support structure of entry driven along, gob-side (EDG) under unstable roof in deep mines and construction method thereof. The asymmetric support structure includes roadway roof support structure, a gob-side support structure and a solid coal seam-side support structure. The roadway roof support structure includes a reinforcing wire mesh, a W-section steel strap, high-strength pretensioned bolts, and cable bolts and matching steel straps. The gob-side support structure includes a reinforcing wire mesh, a W-section steel strap, high-strength pretensioned yielding bolts and grouting cable bolts and its matching steel straps. The solid coal seam-side support structure includes a reinforcing wire mesh, a reinforced beam and steel strap pallet subassembly, high-strength pretensioned yielding bolts and cable bolts and its matching steel straps.
    Type: Application
    Filed: October 31, 2017
    Publication date: July 18, 2019
    Applicant: SHANDONG UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Inventors: Kegong FAN, Chunyuan JING, Shengming NIU, Deli FAN, Chuanwei ZANG
  • Publication number: 20190222155
    Abstract: A servo control strategy and system eliminates CEMF and load torque disturbances. The total disturbance at electrical portion is estimated using extended state observer based on a nominal model of armature winding with measured voltage impressed across two endpoints of armature winding and the measured armature current. The total disturbance at electrical portion is partially counteracted by feed-forward compensation. The remaining CEMF disturbance is eliminated with the aid of armature current feedback regulation. The electrical disturbance can be totally eliminated at inner loop of the system by combining feed-forward control with current feedback control. The total disturbance at mechanical portion is estimated using extended state observer based on a nominal model of drive system with measured armature current and actual speed. The total disturbance at mechanical portion is partially counteracted by feed-forward compensation.
    Type: Application
    Filed: January 16, 2017
    Publication date: July 18, 2019
    Applicant: SHANDONG UNIVERSITY
    Inventor: Jinbo LIU
  • Publication number: 20190218686
    Abstract: The present disclosure relates to tellurite crystals, growing methods of the same, and applications thereof; the crystals a chemical formula of MTe3O8, wherein M=Ti, Zr, Hf, which belongs to an Ia-3 space group of a cubic crystal system, wherein a transmittance waveband ranges from visible light to infrared light, with a transparency ?70%. According to the present disclosure, a growing method of a tellurite crystal is provided, wherein the crystal may be grown using a flux method, a Czochralski method, or a Bridgman-Stockbarger method. The tellurite crystals may be used as an acousto-optic crystal for fabricating an optical modulation device. The present disclosure takes the lead internationally in growing the tellurite single crystals, the size and quality of which sufficiently meet the demands of practical applications of the tellurite single crystals.
    Type: Application
    Filed: September 30, 2017
    Publication date: July 18, 2019
    Applicant: SHANDONG UNIVERSITY
    Inventors: Xutang TAO, Weiqun LU, Zeliang GAO, Youxuan SUN, Qian WU
  • Patent number: 10351857
    Abstract: It relates to a LfliZ gene and its application. The sequence of gene LfliZ is shown in SEQ ID NO.1. This invention also relates to the recombinant protein LfliZ encoded by LfliZ gene and its application in preparation of 2?, 3?-cNMPs. The recombinant LfliZ protein encoded by gene LfliZ can bind four kinds of 2?, 3?-cNMPs during its expression in Escherichia coli. Four kinds of 2?, 3?-cNMPs can be prepared simultaneously from the recombinant E. coli by extracting the recombinant protein LfliZ. The yield of 2?, 3?-cNMPs reaches 2.5 mg/L fermentation broth by the method in the present invention, indicating that this method has a good application potential.
    Type: Grant
    Filed: October 24, 2016
    Date of Patent: July 16, 2019
    Assignee: SHANDONG UNIVERSITY
    Inventors: Xiulan Chen, Yuzhong Zhang, Ang Liu, Xiaoyan Song, Yang Yu, Pingyi Li, Xiying Zhang, Mei Shi, Binbin Xie, Hainan Su, Qilong Qin
  • Publication number: 20190212213
    Abstract: A fiber grating sensor insert, implanting system and method of an intelligent plastic pipe.
    Type: Application
    Filed: September 28, 2017
    Publication date: July 11, 2019
    Applicants: SHANDONG UNIVERSITY, SHANDONG UNIVERSITY, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, CHANGCHUN INSTITUTE OF APPLIED CHEMISTRY, CHINESE ACADEMY OF SCIENCES, JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., JILIN CORE LOGISTICS AND COATING EQUIPMENT CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD., SHANDONG GELNNT ENVIRONMENTAL TECHNOLOGY CO., LTD.
    Inventors: Yuxi JIA, Linlin GAO, Lijia AN, Weiguo YAO, Guoshun WAN, Hui YE, Leida ZHANG
  • Publication number: 20190204191
    Abstract: A method and device for preparing karst caves based on 3D printing technology. The method includes the following steps: determining size of a sample according to test requirements, constructing a 3D karst cave digital model based on three-dimensional karst cave scanning result, and carrying out 3D printing by using alloy to form primary karst cave sample; preparing rock similar material mixture according to proportioning scheme; pouring mixture into sample mold while burying karst cave model into mixture according to position of a karst cave; curing sample together with mold at room temperature until rock similar materials get hardened, removing mold, curing formed karst cave rock sample at constant temperature and constant humidity and then baking or heating same by electrifying heating wire in alloy to form rock sample with hollow karst cave; and filling hollow karst cave with different fillings to form different type of karst cave sample.
    Type: Application
    Filed: January 10, 2018
    Publication date: July 4, 2019
    Applicant: SHANDONG UNIVERSITY
    Inventors: Shucai LI, Zhenhao XU, Bin GAO, Xintong WANG, Wenyang WANG, Yuchao DU, Xin HUANG, Dongdong PAN, Peng LIN
  • Publication number: 20190206279
    Abstract: A whole-process simulation experiment system has: a visualized model system with test samples and serving as a bearing device for the simulation of whole-process seepage of filling-type karst; a controllable support system supporting a visualized model box and controlling fluid seepage direction in the box by changing its inclination angle; a servo loading system controlling water pressure in the test process and providing four different loading modes for the box; a high-speed camera system recording water flow and particle motion in a transparent seepage model box in the seepage failure process; a comprehensive data measuring system monitoring and recording the change rules of factors including but not limited to seepage pressure, seepage amount and sand gushing amount in the seepage failure process; and an information analysis and feedback system recording and analyzing the seepage process and the whole seepage failure process in real time to achieve data processing and feedback.
    Type: Application
    Filed: December 14, 2017
    Publication date: July 4, 2019
    Applicant: SHANDONG UNIVERSITY
    Inventors: Shucai LI, Zhenhao XU, Xintong WANG, Peng LIN, Xin HUANG, Dongdong PAN, Wenyang WANG, Bin GAO
  • Publication number: 20190189005
    Abstract: The present invention provides a method for judging a highway abnormal event, which can determine the traffic jam phenomenon in the target road segment based on the trajectory data of each sample vehicle of the target road segment. The solution of the present invention has the following beneficial effects of 1. comprehensively considering the vehicle speed information of the sample vehicles to judge the traffic jam event; 2. determining the overall traffic jam event of the target road segment; 3. more accurately judging the traffic jam event of the target road segment.
    Type: Application
    Filed: March 28, 2018
    Publication date: June 20, 2019
    Applicants: SHANDONG PROVINCIAL COMMUNICATIONS PLANNING AND DESIGN INSTITUTE, TSINGHUA UNIVERSITY
    Inventors: Kai ZHAO, Yufeng BI, Yong LI, Wei LIU, Depeng JIN, Weiling WU, Pengfei ZHOU, Li SU, Zhen TU, Tao MU, Peiyang FANG, Huajun PANG, Chuanyi MA