Patents Assigned to SHANGHAI ARYL PHARMTECH CO., LTD.
  • TETRACYCLIC DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE
    Publication number: 20230295163
    Abstract: The present invention relates to a tetracyclic derivative, a method for preparing same and the use thereof in medicine. In particular, the present invention relates to a tetracyclic derivative represented by general formula (I), a method for preparing same and a pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, especially as a K-Ras GTPase inhibitor, with definitions of each substituent in general formula (I) being the same as of which are defined in the description.
    Type: Application
    Filed: August 19, 2021
    Publication date: September 21, 2023
    Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD., SHANGHAI ARYL PHARMTECH CO., LTD.
    Inventors: Youxi CHEN, Chaoying CHENG, Liang GONG, Wentao MAO, Qing XIANG, Weifeng ZHAO, Wenwen ZHAO, Yanling HE, Mingjiang ZHU, Cheng YE, Taishan HU, Wenjian QIAN, Lei CHEN
  • SALT OF TETRAHYDROISOQUINOLINE DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICAL USE THEREOF
    Publication number: 20230242522
    Abstract: The present invention relates to a pharmaceutically acceptable salt of (S)-2-(6-fluorobenzo[d]oxazol-2-yl)-6-methoxy-5-((5-methoxypyridin-2-yl))methoxy)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid, a preparation method therefor, a pharmaceutical composition comprising the pharmaceutically acceptable salt thereof, and the use thereof as a therapeutic agent, in particular as an angiotensin II type-2 receptor antagonist.
    Type: Application
    Filed: June 25, 2021
    Publication date: August 3, 2023
    Applicants: ZHEJIANG HISUN PHARMACEUTICAL CO., LTD., SHANGHAI ARYL PHARMTECH CO., LTD.
    Inventors: Yanghui GUO, Lichen MENG, Xiangui HUANG, Weiwei LIAO, Yongxiang GONG, Daiwang XU, Taishan HU, Lei CHEN