Patents Assigned to SHANGHAI BEGREAT PHARMATECH
  • Polymorph of rucaparib camsylate
    Patent number: 11352362
    Abstract: The present disclosure may disclose a new crystal form D of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl) methanesulfonic acid salt, preparation method therefor and a medicinal use. Compared to the existing crystalline forms, this new crystalline form has clear advantages with respect to solubility, stability, and the preparation process.
    Type: Grant
    Filed: April 22, 2020
    Date of Patent: June 7, 2022
    Assignee: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming Meng
  • Polymorps of cariprazine hydrochloride and preparation method thereof and use of same
    Patent number: 11319293
    Abstract: The present disclosure discloses crystal forms A, B, and C of trans-N-{4-[2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl]-cyclohexyl}-N?,N?-dimethylurea hydrochloride, a preparation method, and a medicinal use thereof. Compared to the existing crystalline forms, the new crystalline forms have clear advantages with respect to solubility, stability, and the preparation process.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: May 3, 2022
    Assignee: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming Meng
  • POLYMORPH OF RUCAPARIB CAMSYLATE AND PREPARATION METHOD THEREOF AND USE OF SAME
    Publication number: 20200291036
    Abstract: The present disclosure may disclose a new crystal form D of 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one ((1S,4R)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl) methanesulfonic acid salt, preparation method therefor and a medicinal use. Compared to the existing crystalline forms, this new crystalline form has clear advantages with respect to solubility, stability, and the preparation process.
    Type: Application
    Filed: April 22, 2020
    Publication date: September 17, 2020
    Applicant: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming MENG
  • NOVEL POLYMORPS OF CARIPRAZINE HYDROCHLORIDE AND PREPARATION METHOD THEREOF AND USE OF SAME
    Publication number: 20200231552
    Abstract: The present disclosure discloses crystal forms A, B, and C of trans-N-{4-[2-[4-(2,3-dichlorophenyl)-piperazine-1-yl]-ethyl]-cyclohexyl}-N?,N?-dimethylurea hydrochloride, a preparation method, and a medicinal use thereof. Compared to the existing crystalline forms, the new crystalline forms have clear advantages with respect to solubility, stability, and the preparation process.
    Type: Application
    Filed: April 6, 2020
    Publication date: July 23, 2020
    Applicant: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming MENG
  • Crystal forms of palbociclib, and preparation method and use therefor
    Patent number: 10544142
    Abstract: A plurality of new crystal Forms I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII and XIV of 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, as well as a preparation method and medicinal use therefor are disclosed in the present disclosure. Crystal Form VIII is a semi-hydrate crystal Form. Compared to crystal Forms of the prior art, these new crystal Forms are markedly superior in respect of dissolution, stability, and the preparation process.
    Type: Grant
    Filed: November 8, 2018
    Date of Patent: January 28, 2020
    Assignee: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming Meng
  • Polymorph of pimavanserin tartrate and preparation method thereof and use of same
    Patent number: 10513495
    Abstract: A polymorph III of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-[4-(2-methylpropoxy)phenylmethyl]urea tartrate, a preparation method therefor, and a medicinal use. Compared to the existing crystalline forms, the new crystalline form has clear advantages with respect to solubility, stability and the preparation process.
    Type: Grant
    Filed: November 19, 2018
    Date of Patent: December 24, 2019
    Assignee: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming Meng
  • Crystal form of tenofovir alafenamide salt, preparation method and use thereof
    Patent number: 10479810
    Abstract: Disclosed are a new polymorph II, crystal form A and B of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine fumarate, and preparation methods and pharmaceutical use thereof. The crystal form II is a hemi-fumarate; the crystal form A is a mono-fumarate; and the crystal form B is a sesqui-fumarate. Compared with the existing crystal form, the new crystal forms have obvious advantages in solubility, stability and preparation process.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: November 19, 2019
    Assignee: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming Meng
  • CRYSTAL FORM OF TENOFOVIR ALAFENAMIDE SALT, PREPARATION METHOD AND USE THEREOF
    Publication number: 20190100542
    Abstract: Disclosed are a new polymorph II, crystal form A and B of 9-[(R)-2-[[(S)-[[(S)-1-(isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]methoxy]propyl]adenine fumarate, and preparation methods and pharmaceutical use thereof. The crystal form II is a hemi-fumarate; the crystal form A is a mono-fumarate; and the crystal form B is a sesqui-fumarate. Compared with the existing crystal form, the new crystal forms have obvious advantages in solubility, stability and preparation process.
    Type: Application
    Filed: December 4, 2018
    Publication date: April 4, 2019
    Applicant: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming MENG
  • NOVEL POLYMORPH OF PIMAVANSERIN TARTRATE AND PREPARATION METHOD THEREOF AND USE OF SAME
    Publication number: 20190084935
    Abstract: A polymorph III of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N?-[4-(2-methylpropoxy)phenylmethyl]urea tartrate, a preparation method therefor, and a medicinal use. Compared to the existing crystalline forms, the new crystalline form has clear advantages with respect to solubility, stability and the preparation process.
    Type: Application
    Filed: November 19, 2018
    Publication date: March 21, 2019
    Applicant: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming MENG
  • NEW CRYSTAL FORMS OF PALBOCICLIB, AND PREPARATION METHOD AND USE THEREFOR
    Publication number: 20190071442
    Abstract: A plurality of new crystal Forms I, II, III, IV, V, VI, VII, VIII, IX, X, XI, XII and XIV of 6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-yl-pyridin-2-ylamino)-8H-pyrido[2,3-d]pyrimidin-7-one, as well as a preparation method and medicinal use therefor are disclosed in the present disclosure. Crystal Form VIII is a semi-hydrate crystal Form. Compared to crystal Forms of the prior art, these new crystal Forms are markedly superior in respect of dissolution, stability, and the preparation process.
    Type: Application
    Filed: November 8, 2018
    Publication date: March 7, 2019
    Applicant: SHANGHAI BEGREAT PHARMATECH
    Inventor: Xiaoming MENG