Abstract: Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

Abstract: A microRNA (miRNA) inhibitor, being able to form a stable DNA-RNA double-stranded structure with a miRNA. The double-stranded structure comprises: (i) a miRNA unit sequence, and (ii) an RNA zipper unit sequence. The 5?-end of the RNA zipper unit sequence is connected to the 5?-end of the miRNA unit sequence. The 3?-end of the RNA zipper unit sequence is connected to the 3?-end of the miRNA unit sequence. The RNA zipper can connect the head of the miRNA molecule to the tail of the miRNA molecule to form a stable long-chain structure. The RNA zipper unit sequence contains 1-3 nucleotides not connected to the miRNA unit sequence. The DNA-RNA double-stranded structure can be used to inhibit biological activities of a miRNA unit, does not have biological toxicity, and has the advantages of high affinity, high specificity and high stability.

Abstract: The present disclosure relates to a primer and a kit for rapid detection of bacteria and an application thereof, belonging to the technical field of bacterial detection. The present disclosure provides a primer for rapid detection of bacteria, a nucleotide sequence of a forward primer for the detection is shown in SEQ ID NO.1, and a nucleotide sequence of a reverse primer is shown in SEQ ID NO.2; a degenerate base W=A/T in the forward primer, and a degenerate base R=A/G in the reverse primer. The primer of the present disclosure may achieve rapid, wide, high-sensitivity and quantitative detection of bacteria, can be applied in the field of bacterial detection, and is more suitable for the clinical research and application of cells and stem cell-based products.

Abstract: A microRNA (miRNA) inhibitor, being able to form a stable DNA-RNA double-stranded structure with a miRNA. The double-stranded structure comprises: (i) a miRNA unit sequence, and (ii) an RNA zipper unit sequence. The 5?-end of the RNA zipper unit sequence is connected to the 5?-end of the miRNA unit sequence. The 3?-end of the RNA zipper unit sequence is connected to the 3?-end of the miRNA unit sequence. The RNA zipper can connect the head of the miRNA molecule to the tail of the miRNA molecule to form a stable long-chain structure. The RNA zipper unit sequence contains 1-3 nucleotides not connected to the miRNA unit sequence. The DNA-RNA double-stranded structure can be used to inhibit biological activities of a miRNA unit, does not have biological toxicity, and has the advantages of high affinity, high specificity and high stability.

Abstract: A hollow celiac minimally invasive surgery endoscopic channel may include an extracorporeal combined platform and an intracorporeal expandable shell body. The combined platform and the intracorporeal expandable shell body may be engagingly combined into a detachable structure. The intracorporeal expandable shell body may be in a triangular frustum shape. A portion of the intracorporeal expandable shell body that is located below the triangular frustum surface may be a two-layer structure body. Partition stiffeners that are distributed horizontally may be provided between an inner and outer layers at each face of the shell body. An inflation port may be disposed at the inner layer.