Abstract: A preparation method of a high-moisture-permeability fluorine-containing super-oleophobic microporous membrane is provided having the following steps: (1) preparing a white opaque mixture of fluorine-containing polymers: adding the materials in sequence according to a weight ratio of A50%˜90%:B3%˜25%:C0%˜35%:D0 %˜3%, and stirring and mixing uniformly in a non-shear manner; A is a blend of a high molecular weight polytetrafluoroethylene dispersion resin and a fluorine-containing ion exchange resin; B is a fluorine-containing alkyl acrylate monomer, or a fluorine-containing alkyl methacrylate monomer, or a mixture thereof; C is a polyurethane acrylate prepolymer, or a fluorine-free alkyl acrylate monomer, or a mixture thereof; D is a high temperature free radical initiator; (2) pouring the white opaque mixture into the blank pressing column barrel, and pressing a blank; (3) calendering into strips; (4) stretching and thermally shaping to form a membrane.