Patents Assigned to Shanghai Institute of Materia Medica, CAS
  • Pyrimidinyl-propionic acid derivatives and their use as PPAR agonists
    Patent number: 8513233
    Abstract: The present invention disclosed compounds of Structural Formula (I), and enantiomer, racemic body, pharmaceutically acceptable salts, solvates or hydrates thereof, wherein variable groups are as defined within, as well as methods for preparing such compounds. The compounds are useful as PPAR? agonist, through activating PPAR-RXR heterodimers that interacts with specific DNA response elements within promoter regions of target gene, particularly in the treatment and prevention of polycystic kidney and cancer.
    Type: Grant
    Filed: October 11, 2007
    Date of Patent: August 20, 2013
    Assignee: Shanghai Institute of Materia Medica, CAS
    Inventors: Jianhua Shen, Changlin Mei, Hualiang Jiang, Bin Dai, Yangliang Ye, Xishan Xiong, Jing Tang, Lili Fu