Abstract: Disclosed by the present invention are an SIRT6 small-molecule allosteric activator and the application thereof and provided is an SIRT6 small-molecule allosteric activator that contains a derivative as shown in formula (1) or a pharmacologically acceptable salt thereof as the active ingredient. The SIRT6 small-molecule allosteric activator designed and synthesized in the present invention has high efficacy and low toxicity, may significantly activate SIRT6 activity during in vitro experiments, and has great importance in the development of pharmaceuticals for relevant diseases.

Abstract: Disclosed is a dental implant distractor, comprising an implant module and a traction module. The implant module comprises an implant, a sealing screw, and a base body. The traction module comprises a connecting screw rod, a traction screw rod, an inner sleeve, and an outer sleeve; the connecting screw rod is threadedly connected to the base body; the traction screw rod is located below the connecting screw rod; the inner sleeve is provided below the base body. This apparatus can automatically complete the installation of the base body and the sealing of the connecting screw rod after traction is completed; since the installation of the base body and the sealing do not need to be performed again, operation steps are simplified, the clinical operation difficulty is reduced, and the problem of slippage of an upper bone section to the original position is avoided.

Abstract: Methods of preparing and using a highly active blood coagulation factor XI mutant and a gene therapy/editing vector thereof and a recombinant/fusion protein thereof. The nucleotide sequence of the mutant is as shown in SEQ ID NOs: 1-6, and the amino acid sequence is as shown in SEQ ID NO: 7.

Abstract: The present disclosure relates to an apparatus and a method for high-precision three-dimensional printing using a salt solution. The apparatus includes a receiving platform system and a printing device. The receiving platform system includes a conductivity cell, a high-voltage electrostatic generation system, a printing platform, and a printing platform driver. The conductivity cell contains salt solution. The high-voltage electrostatic generating system is connected with the conductivity cell. The printing platform is disposed in the salt solution in the conductivity cell. The printing platform driver is connected with the printing platform to drive the printing platform to move along a Z?-axis perpendicular to a horizontal direction. The printing device prints a product on the printing platform. The apparatus is convenient to operate, and solves the problems of low resolution of biological 3D printing, limited product height, and difficulty in using multiple printing methods in combination.

Abstract: A stearoyl amino acid salt having a structural formula of the general formula (I), wherein R1 is H or an aromatic base capable of being substituted by one or more substituents, or a C1-4 straight chain or an alkyl with a branched chain, the substituent being an alcoholic hydroxyl group or a phenolic hydroxyl group; and R2 is a C11-25 saturated or unsaturated aliphatic group. Also provided are methods of preparing the stearoyl amino acid salt, and methods of using the stearoyl amino acid salt. Compared to a prototype drug stearoyl amino acid, the stearoyl amino acid salt described herein has excellent physicochemical properties, good stability, high relative bioavailability, a strong drug effect and a high safety factor. It is thus expected to become a candidate for clinical treatment of neurodegenerative diseases and acute brain injury, and a clinical drug for weight loss, thus having broad application prospects.

Abstract: Disclosed is a skin dilator, comprising an expander (11), a pipe network provided on the skin-side surface wall (111) of the expander (11) composed of longitudinal tube (22) and horizontal tube (21) having a reticular structure and communicating with each other, and a guide tube (24) communicating with the pipe network. The skin dilator further comprises several burrs (25) distributed on the skin-side surface wall (111) of the expander (11), and several small apertures (23) communicating the inner cavity of the tube with the outside are provided on both of the longitudinal tube (22) and horizontal tube(21). The tissue expander can be infused biological agents by the filling port to the skin expanding site through the small apertures (23), which may accelerate the expansion growth of skin, prevent skin complications, such as necrosis.

Abstract: Disclosed is a skin dilator, comprising an expander (11), a pipe network provided on the skin-side surface wall (111) of the expander (11) composed of longitudinal tube (22) and horizontal tube (21) having a reticular structure and communicating with each other, and a guide tube (24) communicating with the pipe network. The skin dilator further comprises several burrs (25) distributed on the skin-side surface wall (111) of the expander (11), and several small apertures (23) communicating the inner cavity of the tube with the outside are provided on both of the longitudinal tube (22) and horizontal tube(21). The tissue expander can be infused biological agents by the filling port to the skin expanding site through the small apertures (23), which may accelerate the expansion growth of skin, prevent skin complications, such as necrosis.

Abstract: A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.

Abstract: An infusion pump comprises a housing (1); and a controller (3), a direct current motor (4), a transmission mechanism (6), a rotary encoder (5), and a liquid reservoir (7), which are located within the housing (1), wherein: a piston (71) is provided within the liquid reservoir (7); the transmission mechanism (6) has one end connected with the piston (71) and the other end connected with the direct current motor (4); the rotation shaft of the rotary encoder (5) is connected with the rotation shaft (41) of the direct current motor (4); the controller (3) is connected with the rotary encoder (5) and is provided thereon with a built-in clock and an input key (2) capable of receiving an external control signal. The infusion pump can freely adjust the infusion time and the infusion dose.

Abstract: An infusion pump comprises a housing (1); and a controller (3), a direct current motor (4), a transmission mechanism (6), a rotary encoder (5), and a liquid reservoir (7), which are located within the housing (1), wherein: a piston (71) is provided within the liquid reservoir (7); the transmission mechanism (6) has one end connected with the piston (71) and the other end connected with the direct current motor (4); the rotation shaft of the rotary encoder (5) is connected with the rotation shaft (41) of the direct current motor (4); the controller (3) is connected with the rotary encoder (5) and is provided thereon with a built-in clock and an input key (2) capable of receiving an external control signal. The infusion pump can freely adjust the infusion time and the infusion dose.

Abstract: A steel plate for funnel chest orthopaedic surgery includes a supporting plate (1), a fixing piece (2), a telescopic fixing piece (3), a guiding head (4) and screws (6). The supporting plate (1) is an elongate steel plate. One end of the supporting plate (1) is designed to be integrated with the fixing piece (2), and the other end is provided with a size-adjusting strap (5). The telescopic fixing piece (3) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the telescopic fixing piece (3) is designed to be integrated with the fixing piece (2), and the other end is provided with a groove. The guiding head (4) is an elongate steel plate with the same width as that of the supporting plate (1). One end of the guiding head (4) is provided with a hook, and the other end is provided with a groove.

Abstract: The invention discloses a tissue engineering graft, comprising:(a) pharmaceutically-acceptable biodegradable material; and (b) seed cells, which can be inoculated on the described biodegradable material and are selected from:(i) fibroblasts; (ii) adipose derived cells, or (iii) mixture of dermal fibroblasts and ASCs according to the ratio of 1:10000-10000:1. The graft can be prepared by mixing of seed cell and pharmaceutically-acceptable biodegradable material, obtaining a construct of seed cells and pharmaceutically-acceptable biodegradable material, then culturing the construct in a bioreactor in vitro. The graft can be used for repairing the defect of tendon tissues.