Abstract: Provided is polypeptide which derives from wild type TNF a and inhibits necrocytosis. The polypeptide contains 10-200 amino acid residues and a sequence QLVVPSE. Also provided is a pharmaceutical composition containing polypeptide. The polypeptide and the pharmaceutical composition containing the polypeptide are capable of inhibiting necrocytosis, thereby being used for treating inflammatory diseases.
Abstract: The present invention provides an antibody facilitating programmed necrosis of cells. The antibody can cause programmed necrosis of cells in the presence of tumor necrosis factor (TNF). Therefore, an inhibitor for the antibody can be used in the treatment of inflammatory diseases. Further, the present invention provides the application of the antibody facilitating programmed necrosis of cells in the inflammatory disease prognosis.