Abstract: An implant delivery tube fitting (12) and an implant delivery system. The implant delivery tube fitting (12) is used for loading and delivering an implant, and the implant delivery tube fitting (12) comprises, sequentially from a proximal end to a distal end, an outer tube (122) and a capsule (121). The inner lumen of the capsule (121) is adapted to receive an implant, and the capsule (121) is provided at the distal end of the outer tube (122). The capsule (121) has a telescopic structure, and the outer tube (122) can drive the capsule (121) to make a telescopic movement so that the capsule (121) is lengthened or shortened.

Abstract: The present application discloses an implant loading apparatus comprising a guider and a guide base. The guider is sleeved on the exterior of the guide base. The guide base comprises a guide column, a connecting section, and a base connected in the axial direction. Fixing sections are provided on either end of the connecting section. The guide base is removably connected to the guider via the fixing sections. The guide base is provided with the two fixing sections that fit the guider to implement twice removable fixing, thus favoring a coaxial operation. A valve stent is neither twisted nor tilted during a compression process, thus increasing loading efficiency, greatly reducing the operation difficulty of a surgery, and allowing the implementation of a single person operation.

Abstract: A guide cap and a loading system for loading an implant into a delivery system are disclosed which are capable of simplifying operations required in interventional surgery using the implant. The guide cap has a lumen passing therethrough and includes: a conical section; a straight or conical tube in communication with a small open end of the conical section; and a flange, wherein a large open end of the conical section flares outward and thereby forms the flange. The loading system includes a guider and the guide cap. During the process of loading the implant into the delivery system, the guide cap enables the valve prosthesis to be coupled to the connector of the delivery system and allows the valve prosthesis to be compressed so as to be entirely capsuled in the delivery system with relatively easy and quick operations, thereby reducing surgery time during its clinical use.

Abstract: A valve prosthesis (10), comprising a stent (1), a leaflet (2), and a skirt (3); the stent (1) comprises an inflow end, an outflow end, and a plurality of wavy segments axially connected; the wavy segments comprise a plurality of reticular structure units disposed circumferentially; the leaflet (2) and the skirt (3) are fixed on the stent (1) respectively; the upper portion of the skirt (3) is provided with indentations (321); the skirt (3) is fixed with the leaflet (2) by means of the indentations (321); the skirt (3) further comprises first protrusion portions (323) extending toward the direction of the outflow end of the stent; one ends of the first protrusion portions (323) are connected with the indentations (321), and the other ends of the first protrusion portions are fixed to the stent (1); by such a way, the connection strength of the skirt (3) and the stent (1) is enhanced; and besides, when the valve prosthesis (10) is implanted at a lower position, perivalvular leakage preventing height can be inc

Abstract: The present application relates to a cardiac valve prosthesis and a stent thereof. The stent comprises an inflow channel, an outflow channel, and a transitional area between the inflow channel and the outflow channel along an axial direction; the outflow channel comprises a cyclic structure and at least two convex structures extending along the axial direction; the at least two convex structures are respectively connected to the end of the cyclic structure distant from the transitional area; a restricted vacant area is formed between adjacent convex structures. The cardiac valve prosthesis and the stent thereof are not only suitable for multiple types of valve replacement, risks of injuries and operation costs are reduced for patients, and the influence of the stent to cardiac functions is minimized.

Abstract: A valve stent and a valve prosthesis. The valve stent is in the shape of a mesh tube, and has a compressed state and an expanded state. The valve stent includes an inflow tract structure, a transition tract structure, an outflow tract structure, and a barb structure. The transition tract structure has a fifth end portion, a sixth end portion, and a first middle section. In the expanded state, the diameters of the radial sections of the fifth end portion and the sixth end portion are greater than the diameter of the radial section of the first middle section of the transition tract structure. The outflow tract structure has a seventh end portion and an eighth end portion. The seventh end portion of the outflow tract structure is fixedly connected to the sixth end portion of the transition tract structure, and the eighth end portion is a free end.

Abstract: A mitral valve prosthesis, a tricuspid valve prosthesis and a stent thereof. The stent is configured to support the heart valves of the mitral valve prosthesis and has a contracted configuration for delivery and an expanded configuration for deployment. The stent comprises, along its axial direction, an inflow section, a transition section and an outflow section, and the transition section is connected to the inflow section at one end and to the outflow section at the other end. When in the expanded configuration, the inflow section is located upstream of the outflow section with respect to the blood flow direction. The inflow section is less radially rigid than the outflow section and/or the transition section. Due to such a small radial rigidity, the inflow section can well adapt itself to the anatomy of the native mitral annulus.

Abstract: An implant delivery device (100) includes a casing (110); and inner and outer tube driving members (150, 160), an inner tube (120), an intermediate tube (130), an outer tube (140) and an air-evacuation locking assembly (170), each at least partially accommodated in the casing (110). The three tubes are sequentially nested in one another, and first, second and third spaces are formed between neighbouring tubes. The inner tube driving member (150) has a proximal end that is sealingly fixed to a proximal end of the inner tube (120), and the outer tube driving member (160) is sealingly fixed to a proximal end of the outer tube (140). The intermediate tube (130) has a proximal end that is sealingly fixed to the inner tube driving member (150), and the intermediate tube extends through and is sealingly connected to the outer tube driving member (160). The air-evacuation locking assembly (170) is detachably coupled to the inner tube driving member (150).

Abstract: A stent (1) used for a heart valve prosthesis and the heart valve prosthesis that includes the stent (1) and is used for heart valve replacement. The stent is configured to support a heart valve (3) and includes, along a longitudinal axis, an inflow section (8), an outflow section (6) and a transition section (7) between the inflow section (8) and the outflow section (6). The stent (1) has a contracted delivery configuration and an expanded deployed configuration. In the expanded deployed configuration, the inflow section (8) defines a concave contour that is complementary to a structure of a native valve annulus. The concave contour enables self-deployment and close adherence of the stent (1), thereby preventing its displacement and perivalvular leakage after implantation.

Abstract: A drive handle and system for delivering an implant are disclosed. The drive handle includes a manual control unit, an electrical control unit and a transmission mechanism. The manual control unit is connected to the transmission mechanism to actuate the transmission mechanism to drive a delivery catheter for delivering the implant. The electrical control unit is connected to the transmission mechanism to actuate the transmission mechanism to drive the delivery catheter. The drive handle is switchable between a manual drive/control mode and an electrical drive/control mode to drive the delivery catheter to deliver the implant. The operation is simple, and the operating physician can take full advantage of the two modes to perform the surgical procedure based on his/her own operational preferences. This can result in higher surgical accuracy. Further, by providing these two modes, the apparatus has an increased the security and a reduced surgical risk.

Abstract: A dry animal-derived collagen fiber tissue material and preparation method and bioprosthesis thereof are disclosed. The preparation method includes: 1) rinsing of an animal-derived collagen fiber tissue material that has been treated with a crosslinking agent; 2) immersion of the rinsed tissue material in a non-aqueous alcoholic solution for dehydration; 3) successive immersion of the tissue material that has been dehydrated with the non-aqueous alcoholic solution in saccharide solutions of different gradients of concentrations for gradient dehydration; 4) taking out and drying of the gradient dehydrated tissue material; and 5) hermetic packaging of the dried tissue material and sterilization. The preparation method is simple and allows the use of easily-available low-cost materials, resulting in lower costs. In addition, it can reduce the toxicity caused by a residue of the aldehyde crosslinking agent.

Abstract: An implant capsule (10) and an implant delivery system are disclosed. The implant capsule (10) includes, sequentially from a proximal end to a distal end, a flexural section (102, 102a-102e), a reinforcement section (101, 101a-101e) and a radiopaque reinforcement ring (104a-104e). The reinforcement section (101, 101a-101e) has higher strength than the flexural section (102, 102a-102e). The implant delivery system includes the implant capsule (10). The implant capsule (10) can ensure the implant to be deployed in a coaxial condition and prevent over-expansion due to large expansion forces exerted by a stent of the implant.

Abstract: A device and method for loading an implant into a delivery system are disclose which are capable of simplifying operations required in interventional surgery using the implant. The device includes a guide cap (1), a guider (2) and a guiding tube (3). The guide cap (1) has a conical section (101) and a straight or conical tube (103) in communication with a small open end (102) of the conical section, and the conical section has a large open end (104) that flares outward, thereby forming a flange (105) facing the tube (103). The guider (2) has tapered sections (9, 10) that are tapered along an axis of the guider and thus form large and small open ends (8, 11). The small open end (11) has a diameter greater than a diameter of the small open end (102) of the conical section of the guide cap (1).

Abstract: An electric handle for delivering an implant is disclosed. The electric handle (1) includes an electric control unit (10), a power-driven transmission mechanism (20), a handle housing (30), an outer tube anchor (40) and an inner tube anchor (50), wherein: the electric control unit (10) is operatively coupled to the power-driven transmission mechanism (20) to actuate the power-driven transmission mechanism (20); the power-driven transmission mechanism (20) is supported within the handle housing (30) and moveable together with the outer tube anchor (40); the inner tube anchor (50) is disposed within the handle housing (30) and is configured to hold an inner tube (3) of a delivery system; and the outer tube anchor (40) is configured to hold an outer tube (2) of the delivery system and is fixed to an end of the outer tube (2). A delivery system used especially for delivery of prosthetic valves is also disclosed, including an outer tube (2), an inner tube (3), an expandable implant (4) and the electric handle (1).

Abstract: A dry animal-derived collagen fiber tissue material and preparation method and bioprosthesis thereof are disclosed. The preparation method includes: 1) rinsing of an animal-derived collagen fiber tissue material that has been treated with a crosslinking agent; 2) immersion of the rinsed tissue material in a non-aqueous alcoholic solution for dehydration; 3) successive immersion of the tissue material that has been dehydrated with the non-aqueous alcoholic solution in saccharide solutions of different gradients of concentrations for gradient dehydration; 4) taking out and drying of the gradient dehydrated tissue material; and 5) hermetic packaging of the dried tissue material and sterilization. The preparation method is simple and allows the use of easily-available low-cost materials, resulting in lower costs. In addition, it can reduce the toxicity caused by a residue of the aldehyde crosslinking agent.

Abstract: An implant delivery system is disclosed which includes an inner tube assembly, an outer tube assembly and a functional handle. The functional handle includes a threaded rod, a push-pull control member, a casing tube, a displacement tube, an inner tube fixing member, an outer tube fixing member and a stability tube fixing member. The threaded rod extends through a bore of the displacement tube. A fastener of the push-pull control member is able to engage a thread provided on a leading portion of the threaded rod. A trailing portion of the threaded rod is provided with a knob. The push-pull control member includes a fastener, springs and a button. The fastener is able to extend through a slot to engage a thread of the threaded rod in the displacement tube. The springs are configured to cause an automatic locking of the fastener and the threaded rod. The button is provided on the fastener.